Results 191 to 200 of about 481,217 (224)

Ultralow‐Dimensionality Reduction for Identifying Critical Transitions by Spatial‐Temporal PCA

Advanced Science, EarlyView.
The proposed spatial‐temporal principal component analysis (stPCA) method analytically reduces high‐dimensional time‐series data to a single latent variable by transforming spatial information into temporal dynamics. By preserving the temporal properties of the original data, stPCA effectively identifies critical transitions and tipping points.
Pei Chen, Yaofang Suo, Kazuyuki Aihara, Ye Li, Dan Wu, Rui Liu, Luonan Chen   +6 more
wiley   +1 more source

Elucidating long non-coding RNA networks in tomato plants in response to Funneliformis mosseae colonization and cucumber mosaic virus infection. [PDF]

BMC Plant Biol
Maleki N, Ghorbani A, Rostami M, Maina S.   +3 more
europepmc   +1 more source

RNF112 Facilitates Ubiquitin‐Mediated Degradation of c‐Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer

Advanced Science, EarlyView.
RNF112, an E3 ubiquitin ligase, is markedly reduced in bladder cancer (BLCA). It curbs BLCA cell proliferation, migration, and lipid production primarily by enhancing ubiquitin‐dependent degradation of c‐Myc. This degradation inhibits c‐Myc's role in upregulating ACLY, a crucial enzyme for lipid synthesis, highlighting RNF112's potential as a ...
Kangping Xiong, Siming Chen, Huimin Xu, Sheng Tu, Hong Weng, Yejinpeng Wang, Mingxing Li, Jingtian Yu, Kaiyu Qian, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Gang Wang   +13 more
wiley   +1 more source

Correction: Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene. [PDF]

Oncol Res
Huang X, Chen C, Chen Y, Zhou H, Chen Y, Huang Z, Xie Y, Liu B, Guo Y, Yang Z, Chen G, Su W.   +11 more
europepmc   +1 more source

A 3D Genome Atlas of Genetic Variants and Their Pathological Effects in Cancer

Advanced Science, EarlyView.
The hierarchical organization of the eukaryotic genome is vital for nuclear function, and disruptions from genetic mutations can alter this 3D architecture. Cataloging thousands of interchromosomal translocations, structural variants, and single nucleotide polymorphisms, their impact on 3D genome organization is revealed. The scoring algorithm, 3DFunc,
Li Tang, Matthew C. Hill, Mingxing He, Junhao Chen, Zirui Wang, Patrick T. Ellinor, Min Li   +6 more
wiley   +1 more source

[Retracted] Role of long non‑coding RNA MALAT1 in chronic obstructive pulmonary disease. [PDF]

Exp Ther Med
Hu TJ, Huang HB, Shen HB, Chen W, Yang ZH.   +4 more
europepmc   +1 more source

Single‐Cell Transcriptomes of Immune Cells from Multiple Compartments Redefine the Ontology of Myeloid Subtypes Post‐Stroke

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Using single‐cell sequencing in a murine stroke model (p‐MCAO), three stroke‐specific subpopulations are identified: disease inflammatory macrophage (DIM), disease‐associated microglia (DAM), and CD14+ neutrophils (Neut_Cd14). Detailed analyses reveal that Neut_Cd14 and DIM subtypes are skull‐derived, whereas DAM likely originates from homeostatic ...
Mo Yang, Yixiang Li, Kaibin Shi, Xuezhu Wang, Xiangrong Liu, Xiang Huang, Fu‐Dong Shi, Shaojie Ma, Mingfeng Li, Yilong Wang   +9 more
wiley   +1 more source

Identification of a long non-coding RNA signature associated with cuproptosis for prognosis and immunotherapy response prediction in patients with lung adenocarcinoma. [PDF]

Discov Oncol
Zeng J, Wu Z, Luo M, Chen Z, Xu X, Xie G, Chen Q, Bai W, Xiao G, Xie J.   +9 more
europepmc   +1 more source

Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization

Advanced Science, EarlyView.
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao, Yule Yong, Zhaohui Zheng, Kui Zhang, Wei Li, Jiayi Liu, Siyi Zhou, Juan‐juan Qin, Haoyang Sun, Yatao Wang, Xianghui Fu, Xing Luo, Siyu Chen, Zhi‐Gang She, Jingjing Cai, Ping Zhu   +15 more
wiley   +1 more source

Autophagy-related long non-coding RNA MIR210HG plays a therapeutic role in hepatocellular carcinoma. [PDF]

Discov Oncol
Zhang C, Sun D, Zhou H, Liu C, Ruan J, Kang J, Xie Y.   +6 more
europepmc   +1 more source