Results 31 to 40 of about 2,450 (224)

Ascites circRNA ASCOR Drives Platinum Resistance of High‐Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation

Advanced Science, EarlyView.
High‐grade serous ovarian carcinoma (HGSOC) is plagued by platinum resistance, with malignant ascites closely linked to poor outcomes. Here, we identify ASCOR, a circRNA enriched in ascites small extracellular vesicles (sEVs) from platinum‐resistant HGSOC patients, as a predictor of poor survival. ASCOR enhances platinum resistance in vitro and in vivo
Hanyuan Liu, Chenchen Zhu, Xuelin Yao, Yi Liu, Jing Zhu, Yuebo Li, Hanjie Xu, Cheng Peng, Ge Shan, Liang Chen, Ying Zhou   +10 more
wiley   +1 more source

Serendipitous Archival Observations of a New Ultradistant Comet C/2019 E3 (ATLAS)

The Astronomical Journal
We identified a new ultradistant comet C/2019 E3 (ATLAS) exhibiting preperihelion cometary activity at heliocentric distances ≳20 au, making it the fourth member of this population after C/2010 U3 (Boattini), C/2014 UN _271 (Bernardinelli–Bernstein), and
Man-To Hui, Robert Weryk, Marco Micheli, Zhong Huang, Richard Wainscoat   +4 more
doaj   +1 more source

Pro‐ATO/Allicin Liposomes for Dual‐Pathway Targeting of p53‐Mutant Tumors

Advanced Science, EarlyView.
Schematic illustration of the “pro‐ATO”/allicin liposomal strategy. Liposomal encapsulation improves the stability and bioavailability of both agents while masking allicin's odor. Upon release in the tumor microenvironment, ATO reactivates structural p53 mutants, and allicin inhibits ATR signaling while releasing H2S, collectively inducing synthetic ...
Xiaoling Xu, WeiYi Cheng, Menghang Yang, Li He, WeiYe Ren, JingQuan Chen, LiTing He, Dandan Bao, Zhihong Zhu, Lixin Wang, Qinghua Yao, Ji‐Gang Piao   +11 more
wiley   +1 more source

The Extreme Activity in Comet Hale–Bopp (C/1995 O1): Investigations of Extensive Narrowband Photoelectric Photometry

The Planetary Science Journal
Conventional narrowband photoelectric photometry of Comet Hale–Bopp (1995 O1) was obtained on 99 nights from mid-1995 to early-2000, yielding gas and dust production rates over an unprecedented range of time and distance. The appearance of Hale–Bopp (H-B)
David G. Schleicher, Peter V. Birch, Tony L. Farnham, Allison N. Bair   +3 more
doaj   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Demise of Kreutz Sungrazing Comet C/2024 S1 (ATLAS)

The Astronomical Journal
Most Kreutz family sungrazing comets are discovered only days before perihelion, severely limiting observational opportunities to study their physical nature and decay.
David Jewitt, Jane Luu, Jing Li
doaj   +1 more source

Nongravitational perturbations of long-period comets

The Astronomical Journal, 1979
The model of Marsden et al. (1973) is used to investigate the effect of nongravitational forces resulting from water ice sublimation on the orbits of long-period comets. The orbits of hypothetical comets with perihelion distances of 0.005 to 4 AU are integrated numerically along initially parabolic trajectories through one perihelion passage for ...
openaire   +1 more source

Endogenous Amplification of Apoptosis via p53 Regulation using a Cascade Nanocatalytic Medicine

Advanced Science, EarlyView.
An engineered MOF nanomedicine (MAL) triggers cascade nanocatalysis in tumors, converting H2O2 and L‐Arg into cytotoxic peroxynitrite. This induces DNA damage, activates the p53 pathway, and amplifies mitochondrial apoptosis via the BAX/Bcl‐2/Caspase‐3 axis, effectively inhibiting colorectal cancer growth with high biocompatibility.
Tan Wu, Xiaoyue Xu, Dan Xu, Hui Zhang, Nan Wang, Yang Yang, Qian Chen, Shunjie Chen, Cheng Li   +8 more
wiley   +1 more source

Dust and Volatiles in the Disintegrating Comet C/2019 Y4 (ATLAS)

The Astrophysical Journal
C/2019 Y4 (ATLAS) is an Oort cloud comet with an orbital period of ∼5895 yr. Starting in 2020 March, its nucleus underwent disintegration. In order to investigate the gas and dust properties of C/2019 Y4 (ATLAS) during its disintegration, we obtained ...
Ruining Zhao, Aigen Li, Bin Yang, Liang Wang, Huijuan Wang, Yu-Juan Liu, Jifeng Liu   +6 more
doaj   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source