Results 31 to 40 of about 2,536 (230)

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Serendipitous Archival Observations of a New Ultradistant Comet C/2019 E3 (ATLAS)

The Astronomical Journal
We identified a new ultradistant comet C/2019 E3 (ATLAS) exhibiting preperihelion cometary activity at heliocentric distances ≳20 au, making it the fourth member of this population after C/2010 U3 (Boattini), C/2014 UN _271 (Bernardinelli–Bernstein), and
Man-To Hui, Robert Weryk, Marco Micheli, Zhong Huang, Richard Wainscoat   +4 more
doaj   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

The Extreme Activity in Comet Hale–Bopp (C/1995 O1): Investigations of Extensive Narrowband Photoelectric Photometry

The Planetary Science Journal
Conventional narrowband photoelectric photometry of Comet Hale–Bopp (1995 O1) was obtained on 99 nights from mid-1995 to early-2000, yielding gas and dust production rates over an unprecedented range of time and distance. The appearance of Hale–Bopp (H-B)
David G. Schleicher, Peter V. Birch, Tony L. Farnham, Allison N. Bair   +3 more
doaj   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Demise of Kreutz Sungrazing Comet C/2024 S1 (ATLAS)

The Astronomical Journal
Most Kreutz family sungrazing comets are discovered only days before perihelion, severely limiting observational opportunities to study their physical nature and decay.
David Jewitt, Jane Luu, Jing Li
doaj   +1 more source

Coma Abundances of Volatiles at Small Heliocentric Distances: Compositional Measurements of Long-period Comet C/2020 S3 (Erasmus)

The Astronomical Journal, 2023
We report production rates of H _2 O and nine trace molecules (C _2 H _6 , CH _4 , H _2 CO, CH _3 OH, HCN, NH _3 , C _2 H _2 , OCS, and CO) in long-period comet C/2020 S3 (Erasmus) using the high-resolution, cross-dispersed infrared spectrograph (iSHELL)
Chemeda Ejeta, Erika Gibb, Nathan Roth, Michael A. DiSanti, Neil Dello Russo, Mohammad Saki, Adam J. McKay, Hideyo Kawakita, Younas Khan, Boncho P. Bonev, Ronald J. Vervack Jr., Michael R. Combi   +11 more
doaj   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

Outcomes of periodontal therapy: Strengthening the relevance of research to patients. A co‐created review

Periodontology 2000, EarlyView., 2023
Abstract Periodontitis is a long‐term condition affecting up to half of the population globally and causing significant impacts on life quality. Successful management depends on taking life‐long ownership of the condition by those affected. There is a wealth of research to inform on management options. However, most of the research has been designed by
Ian Needleman, Neil Almond, Natalie Leow, Jim Phillips   +3 more
wiley   +1 more source

How Meteor Showers Can Guide the Search for Long-period Comets

The Planetary Science Journal
With orbital periods longer than 200 yr, most long-period comets (LPCs) remain undiscovered until they are in-bound toward perihelion. The comets that pass close to Earth’s orbit are potentially hazardous objects.
Samantha Hemmelgarn, Nicholas Moskovitz, Stuart Pilorz, Peter Jenniskens   +3 more
doaj   +1 more source