Results 91 to 100 of about 266,382 (322)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Síndrome de QT largo Long QT syndrome

Revista Colombiana de Cardiología, 2008
El síndrome de QT largo (SQTL) es una enfermedad que se caracteriza por la alteración electrocardiográfica en la repolarización ventricular que se manifiesta por prolongación del intervalo QT, secundaria a prolongación de la repolarización ventricular ...
Eduardo Contreras Z, Juan E Gómez M, Sandra X Zuluaga M   +2 more
doaj  

Comparison of double bundle semitendinosus technique and pedicled quadriceps technique in patellar instability

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To compare clinical and functional outcomes of medial patellofemoral ligament (MPFL) reconstruction using a minimally invasive pedicled quadriceps tendon (QT) or patella double tunnel technique with semitendinosus tendon (ST) graft in patients with recurrent patella dislocation.
Tayfun Özel, Semih Yaş, Hayati Hürol Türkoğlu, Asim Ahmadov, Muhammet Baybars Ataoğlu, Ulunay Kanatlı   +5 more
wiley   +1 more source

Safety and Effect of 12‐Month Ecopipam Treatment in Pediatric Patients with Tourette Syndrome

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Tourette syndrome (TS) is a chronic neurodevelopmental tic disorder with a considerable quality of life (QOL) burden. Objectives The goal was to determine the long‐term safety, tolerability, and clinical effects of ecopipam, a first‐in‐class dopamine D1 receptor antagonist, for TS.
Donald L. Gilbert, David J.B. Kim, Meredith M. Miller, Sarah D. Atkinson, George B. Karkanias, Frederick E. Munschauer, Stephen P. Wanaski, Timothy M. Cunniff   +7 more
wiley   +1 more source

The genetics underlying acquired long QT syndrome: impact for genetic screening.

European Heart Journal, 2016
AIMS Acquired long QT syndrome (aLQTS) exhibits QT prolongation and Torsades de Pointes ventricular tachycardia triggered by drugs, hypokalaemia, or bradycardia. Sometimes, QTc remains prolonged despite elimination of triggers, suggesting the presence of
H. Itoh, L. Crotti, T. Aiba, C. Spazzolini, I. Denjoy, V. Fressart, K. Hayashi, T. Nakajima, S. Ohno, T. Makiyama, Jie Wu, K. Hasegawa, E. Mastantuono, F. Dagradi, M. Pedrazzini, M. Yamagishi, M. Berthet, Y. Murakami, W. Shimizu, P. Guicheney, P. Schwartz, M. Horie   +21 more
semanticscholar   +1 more source

Traditional Chinese Medicine Properties and Microcalorimetry: BioScience Evaluation

Med Research, EarlyView.
ABSTRACT The properties theory of traditional Chinese medicine (TCM), characterized by cold, hot, warm, and cool four properties, is fundamental to its development, distinguishing it from natural, botanical, and chemical medicines. However, despite its significance, there is no unified theoretical definition, bioscientific characterization, or ...
Qiang Li, Hengrui Liu, Jiayan Jin, Yixin Zhang, Shuyi Li, Lin Wang, Shirong Zhao, Chutse Wu, Zhie Fang, Jide Jin   +9 more
wiley   +1 more source

T-wave alternans in long QT syndrome

Annals of Pediatric Cardiology, 2018
Long QT syndrome (LQTS) is a congenital disorder characterized by prolongation of QT interval in the electrocardiogram (ECG) and a propensity to develop ventricular arrhythmias, which may lead to syncope, cardiac arrest or sudden death. T-wave alternans (
Siddharth Narayan Gadage
doaj   +1 more source

Long QT: Good, bad or indifferent? [PDF]

, 1984
A survey of current literature suggests an increasing interest in both the desirable and undesirable implications of a prolonged QT interval, the former perceived to be the beneficial effect of antiarrhythmic drugs that prolong the duration of ...
Knoebel, Suzanne B., Surawicz, Borys
core   +1 more source

Genetics of Long QT Syndrome [PDF]

Methodist DeBakey Cardiovascular Journal, 2014
Long QT syndrome (LQTS) is a potentially life-threatening cardiac arrhythmia characterized by delayed myocardial repolarization that produces QT prolongation and increased risk for torsades des pointes (TdP)-triggered syncope, seizures, and sudden cardiac death (SCD) in an otherwise healthy young individual with a structurally normal heart.
David J. Tester, Michael J. Ackerman
openaire   +3 more sources

Plasticity of Gene Expression in Spaceflight and Postflight in Relation to Cardiovascular Disease: Mechanisms and Candidate Repurposed Drugs

PROTEOMICS, EarlyView.
ABSTRACT Spaceflight poses unique challenges to human health due to exposure to increased levels of cosmic radiation, microgravity, and associated oxidative stress. These environmental factors can lead to cellular damage, inflammation, and a range of health complications, including cardiovascular problems, immune system impairment, and an increased ...
Marilena M. Bourdakou, Eleni M. Loizidou, George M. Spyrou   +2 more
wiley   +1 more source