Results 111 to 120 of about 7,350,665 (262)

Long-QT syndrome after age 40 [PDF]

, 2008
Long-QT syndrome after age ...
Ackerman MJ, Goldenberg I, Qi M, Zhang L., Polonsky S, Vincent GM, PRIORI, SILVIA GIULIANA, SCHWARTZ, PETER, Moss AJ, Peterson DR, Benhorin J, Locati EH, Bradley J, Robinson JL, Zareba W, Kaufman ES, Andrews ML, Towbin JA, McNitt S, Napolitano C   +19 more
core  

Foetal presentation of long QT syndrome

, 2013
Long-QT syndrome is a rare, inherited cardiac channelopathy that is characterized by arrhythmia, syncope and sudden cardiac death. Foetal symptoms are very rare and prenatal diagnosis is difficult.
Marc Gewillig, Nuyens, Dieter, Chloë Theeuws, Theeuws, Chloe, Dieter Nuyens, Gewillig, Marc   +5 more
core   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

The interplay between dynamic regulation of ion‐channel gating and trafficking in cardiac arrhythmogenesis

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiac cellular electrophysiology is modulated by multiple factors, including temperature, extracellular K+, heart rate/pacing frequency, and drugs. These modulators can have distinct effects on ion‐channel gating and transcription/trafficking over time.
Stefan Meier, Anna S. Savchenko, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Sistema para análise da variabilidade de sinais fisiológicos: aplicação em variabilidade da frequência cardíaca e intervalo QT [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia ElétricaReguladas pela automaticidade intrínseca do nodo sinoatrial e pela influência modulatória do Sistema Nervoso Autônomo, as
Petry, Daiana
core  

Extracellular ionic concentration modulates arrhythmias in a simulated population of human ventricular myocytes with long QT syndrome type 3

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustrating the in silico study pipeline. A total of 50,000 virtual myocytes were generated, which were then filtered to 7093 myocytes that fit experimentally constrained biomarkers for physiological electrical and calcium behaviour under wild‐type conditions.
Katherine Flannery, Jacob A. Miller, Steven Poelzing, Seth H. Weinberg   +3 more
wiley   +1 more source

New perspectives in long QT syndrome

, 2007
Long QT Syndrome (LQTS) is a cardiac channelopathy characterized by prolonged ventricular repolarization and increased risk to sudden death secondary to ventricular dysrrhythmias.
Iturralde-Torres, Pedro, Medeiros Domingo, Argelia, Canizales-Quinteros, Samuel, Tusié-Luna, M. Teresa, Hernández-Cruz, Arturo   +4 more
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In Utero Onset of Long Qt Syndrome with Atrioventricular Block and Spontaneous or Lidocaine-Induced Ventricular Tachycardia: Compound Effects of Herg Pore Region Mutation and Scn5a N-Terminus Variant

, 2011
BACKGROUND Mexiletine may protect patients with long QT syndrome (LQTS) type 3 from arrhythmias. However, we found an unusual in utero presentation of intermittent atrioventricutar block and ventricular tachycardia ( spontaneous or lidocaine-induced) in ...
Lin, Ming-Tai; Wu, Mei-Hwan; Chang, Chien-Chih; Chiu, Shuenn-Nan; Thériault, Olivier; Huang, Hai; Christé, Georges; Ficker, Eckhard; Chahine, Mohamed, 林銘泰;吳美環;張建智;邱舜南   +1 more
core   +1 more source