Results 91 to 100 of about 38,746 (286)

Clinical and genetic characteristics of long QT syndrome

, 2007
Long QT syndrome (LQTS) is an arrhythmogenic ion channel disorder characterized by severely abnormal ventricular repolarization, which results in prolongation of the electrocardiographic QT interval.
Iturralde-Torres, Pedro, Medeiros Domingo, Argelia, Ackerman, Michael J.   +2 more
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Flecainide binding dynamics in voltage‐gated sodium channels: A comparative isoform analysis of the state‐dependent block

British Journal of Pharmacology, EarlyView.
Background and Purpose Local anaesthetics and class I anti‐arrhythmic drugs block voltage‐gated Na+ channels, but the molecular basis for the isoform differences in drug sensitivity remains unclear. Understanding these mechanisms is essential for optimizing therapeutic efficacy and safety.
Tatsuo Munakata, Etsuko Kumada, Nao Katayama, Hiroki Nakagawa, Akihiko Sunami   +4 more
wiley   +1 more source

Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research: In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome: Development of Chronic Atrioventricular Block Model of Microminipig

Journal of Pharmacological Sciences, 2011
A new in vivo proarrhythmia model of drug-induced long QT syndrome was developed using the Microminipig, an incredibly small minipig established by Fuji Micra Inc. (Shizuoka).
Atsushi Sugiyama, Yuji Nakamura, Yasuki Akie, Hiroyuki Saito, Yasukatsu Izumi, Hiroshi Yamazaki, Naoki Kaneko, Katzuhiko Itoh   +7 more
doaj   +1 more source

Molecular basis of cardiac arrhythmias: genetics of natural variants and electrophysiological investigation of mutant proteins

, 2010
Channelopathies are diseases caused by deranged functioning of ion channel subunits or the proteins that regulate them. Long QT and Brugada syndrome are included in this group.
Detta, Nicola
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The long QT syndrome [PDF]

, 2010
peer reviewedThe congenital long QT syndrome (LQTS) is a hereditary cardiac disease characterized by a prolongation of the QT interval > 440 ms at rest ECG associated with a high risk of ventricular arrhythmias (torsade de pointe).
D'Orio, Vincenzo, MELON, Pierre, LANCELLOTTI, Patrizio, PIERARD, Luc, GARWEG, Christophe   +4 more
core  

Optimization of novel compounds using computer‐aided drug design for treatment of cardiac arrhythmia

British Journal of Pharmacology, EarlyView.
Background and Purpose Loss‐of‐function mutations of the voltage‐gated Kv7.1 (KCNQ/KCNE1) channels lead to cardiac arrhythmia such as long QT syndrome, characterized by a prolonged QT interval . One strategy to correct the prolonged QT interval is to design molecules that activate KCNQ1/KCNE1 channels and restore the QT interval.
Jessica Jowais, Laura M. Castro‐Gonzalez, Alessia Golluscio, D. Peter Tieleman, H. Peter Larsson   +4 more
wiley   +1 more source

Le QT long acquis [Acquired long QT syndrome].

, 2013
The long QT syndrome may be acquired or genetically determined. The syndrome is characterized by a prolonged QT interval and is associated with an increased risk of cardiac arrhythmia such as a torsade de pointe and death.
Schlaepfer, J., Zürcher, J.P., Waeber, G., Pasquier, M.   +3 more
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Physiological Basis of Sex Differences in Human Performance and Exercise‐Associated Pathology

Clinical Endocrinology, EarlyView.
ABSTRACT The presence of sex differences in human physical performance is well‐established and shaped by distinct endocrine, anatomical and physiological mechanisms. Despite sustained advances, our understanding of how inherent biological factors drive variations in exercise capacity and related pathologies is still developing.
David A. Holdsworth, Thomas J. O'Leary, Craig L. Doig, Natalie Taylor, Jasminder Dosanjh, David R. Woods, Michael J. Stacey, Robert M. Gifford   +7 more
wiley   +1 more source

Acute Hypokalemia May Not Be an Effective Way to Sensitize the In Situ Canine Heart for Sparfloxacin-Induced Long QT Syndrome

Journal of Pharmacological Sciences, 2006
.: Extents of the sparfloxacin (3 – 10 mg/kg, i.v.)-induced QT interval prolongation under normokalemic and hypokalemic conditions were assessed in halothane-anesthetized beagle dogs (n = 5).
Katsuyoshi Chiba, Atsushi Sugiyama, Kazuo Watanabe, Kiyoshi Takasuna, Keitaro Hashimoto   +4 more
doaj   +1 more source

Long-QT syndrome after age 40 [PDF]

, 2008
Long-QT syndrome after age ...
Ackerman MJ, Goldenberg I, Qi M, Zhang L., Polonsky S, Vincent GM, PRIORI, SILVIA GIULIANA, SCHWARTZ, PETER, Moss AJ, Peterson DR, Benhorin J, Locati EH, Bradley J, Robinson JL, Zareba W, Kaufman ES, Andrews ML, Towbin JA, McNitt S, Napolitano C   +19 more
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