Results 131 to 140 of about 7,350,665 (262)

The genetic architecture of long QT syndrome: A critical reappraisal

, 2018
Collectively, the completion of the Human Genome Project and subsequent development of high-throughput next-generation sequencing methodologies have revolutionized genomic research.
Giudicessi, John R., Michael J. Ackerman, Arthur A.M. Wilde, Wilde, Arthur A. M., John R. Giudicessi, Ackerman, Michael J.   +5 more
core   +1 more source

Aumolertinib Versus Osimertinib as First‐Line Treatment for EGFR‐Mutant Non‐Small Cell Lung Cancer: A Retrospective Real‐World Multicenter Study

International Journal of Cancer, Volume 159, Issue 10, Page 2575-2584, 15 November 2026.
As third‐generation EGFR‐tyrosine kinase inhibitors, both aumolertinib and osimertinib demonstrate clinical efficacy for non‐small cell lung adenocarcinoma, especially in patients with brain metastases. Currently, head‐to‐head studies comparing these two agents in real‐world settings are scarce.
Jinxia Wang, Ping Qi, Jinhua Li, Na Wang, Caihong Fu, Lixin Liu, Shuping Li, Xiao Li, Xiaoming Hou, Hui Qiao   +9 more
wiley   +1 more source

The long QT syndrome

, 2014
The long QT syndrome (LQTS) is an arrhythmogenic syndrome due to cardiac ion channel disorders characterized by prolonged QT interval on ECG (QTc >440 ms for male, >460 ms for female) and the most common presentations are syncope, seizures, cardiac
Marzuillo P., Bonazza P., Berton E., Germani C., Barbi E., D'Alfonso R., Ferrara G.   +6 more
core  

Misdiagnosis of Long QT Syndrome as Epilepsy at First Presentation

, 2009
Study objective Long QT syndrome has significant mortality, which is reduced with appropriate management. It is known that long QT syndrome masquerades as other conditions, including seizure disorders.
MacCormick, Judith M., Skinner, Jonathan R., Crawford, Jackie, French, John K., McAlister, Hugh, Shelling, Andrew N., Crozier, Ian, Mark Rees, Eddy, Carey-Anne, Rees, Mark I.   +9 more
core   +1 more source

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, Volume 46, Issue 6, Page 1939-1957, November 2026.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

Long QT syndrome in patients over 40 years of age: increased risk for LQTS-related cardiac events in patients with coronary disease.

, 2008
Previous studies of long QT syndrome (LQTS) have focused primarily on the clinical course of affected patients up to 40 years of age to avoid the confounding influence of acquired heart disease on LQTS-related cardiac events in this genetic disorder ...
Ackerman MJ, Goldenberg I, Qi M, Zhang L., Spazzolini C, Vincent GM, Towbin J, Sze E, SPAZZOLINI, CARLA, Kaufman E, PRIORI, SILVIA GIULIANA, SCHWARTZ, PETER, Locati E, Moss AJ, Benhorin J, International Long QT Syndrome Investigative G.r.o.u.p. Ackerman MJ, Robinson JL, Jons C, Zareba W, McNitt S, Napolitano C   +20 more
core   +1 more source

Olanzapine for the Prevention and Treatment of ICU Delirium: Protocol for a Systematic Review With Meta‐Analysis

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 10, November 2026.
ABSTRACT Background Intensive care unit (ICU) delirium is a multifactorial acute brain dysfunction associated with prolonged hospitalization, increased morbidity and mortality, and higher healthcare costs. Despite these substantial negative impacts of delirium, the optimal prevention and treatment strategies are unclear.
Benedikte Liebetrau, Andreas Ruhvald Madsen, Sören Möller, Markus Harboe Olsen, Sebastian Wiberg, Simon Mølstrøm   +5 more
wiley   +1 more source

Understanding the Mortality Trends in Patients With Ventricular Arrhythmias and Cardiomyopathy: A 25‐Year Retrospective Analysis From 1999–2024

Annals of Noninvasive Electrocardiology, Volume 31, Issue 6, November 2026.
Central illustration depicting trends in demographics and differences in Ventricular Arrhythmias with Cardiomyopathy‐related Mortality among adults in the United States from 1999 to 2024. ABSTRACT Background Ventricular Arrhythmias (VA) associated with Cardiomyopathy (CM) continues to be the major cause of death.
Nosheen Pervaiz, Hamza Naveed, Muhammad Junaid Razzak, Shaheer Bin Shafiq, Muhammad Hasan, Sawera Gul, Maham Abbasi, Kamil Ahmad Kamil, Syed Ahmed Farhan   +8 more
wiley   +1 more source

Clinical Outcomes After Percutaneous Coronary Intervention in Patients With Cirrhosis: A Multicentre National Study

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 9, Page 1219-1233, November 2026.
Summary of a multicentre TriNetX study evaluating outcomes after percutaneous coronary intervention (PCI) in patients with cirrhosis. Cirrhosis was associated with higher 1‐year gastrointestinal bleeding and mortality, especially with decompensated disease.
Dhir Gala, Sameer Rao, Manas Gunani, Kajol Shah, Anand V. Kulkarni, Karn Wijarnpreecha, Daniel Q. Huang, Pojsakorn Danpanichkul, Ahmed Al‐Khazraji, Kaveh Hajifathalian, Vivek Lingiah, Paul Gaglio, Nikki Duong, Christine Gerula   +13 more
wiley   +1 more source

A Natural History Study of Timothy Syndrome

Orphanet Journal of Rare Diseases
Background Timothy syndrome (OMIM #601005) is a rare disease caused by variants in the gene CACNA1C. Initially, Timothy syndrome was characterized by a cardiac presentation of long QT syndrome and syndactyly of the fingers and/or toes, all associated ...
Katherine W. Timothy, Rosemary Bauer, Kerry A. Larkin, Edward P. Walsh, Dominic J. Abrams, Cecilia Gonzalez Corcia, Alexandra Valsamakis, Geoffrey S. Pitt, Ivy E. Dick, Andy Golden   +9 more
doaj   +1 more source