Results 121 to 130 of about 266,382 (322)

Network medicine and systems pharmacology approaches to predicting adverse drug effects

British Journal of Pharmacology, EarlyView.
Identifying and understanding the relationships between drug intake and adverse effects that can occur due to inadvertent molecular interactions between drugs and targets is a difficult task, especially considering the numerous variables that can influence the onset of such events.
Alessio Funari, Giulia Fiscon, Paola Paci   +2 more
wiley   +1 more source

Never Out of the Woods: Onset of Events in Long QT Syndrome Late in Life Provoked by Atrial Arrhythmias

Indian Pacing and Electrophysiology Journal, 2014
The assessment of risk in the asymptomatic patient with long QT syndrome can often be a challenging task, particularly when the available evidence is limited to relatively small retrospective registries, not to mention the need to consider the effect of ...
Justin Ng, MD, Chirag Barbhaiya, Tobias Reichlin, Koichi Nagashima, Roy John   +4 more
doaj   +1 more source

Proof of concept for monoclonal antibody therapy in a cellular model of acquired long QT syndrome type 3 [PDF]

Long QT syndrome (LQTS) type 3 although less common than the first two forms, differs in that arrhythmic events are less likely triggered by adrenergic stimuli and are more often lethal.
Kis, Lenke, Li, Jin
core   +1 more source

Airway Basal Stem Cells Inflammatory Alterations in COVID‐19 and Mitigation by Mesenchymal Stem Cells

Cell Proliferation, EarlyView.
Airway basal stem cells derived from COVID‐19 patients demonstrated pronounced goblet cell hyperplasia, inflammatory responses and tendencies toward fibrosis. Co‐culture with mesenchymal stem cells (MSCs) notably reduced these pathological changes, likely due to MSCs' regulatory effects on the interferon signalling pathway.
Sheng Du, Jing Jin, Chunli Tang, Zhuquan Su, Lulin Wang, Xinyuan Chen, Mengni Zhang, Yiping Zhu, Jiaojiao Wang, Chunrong Ju, Xinyu Song, Shiyue Li   +11 more
wiley   +1 more source

A new hERG allosteric modulator rescues genetic and drug‐induced long‐QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells

EMBO Molecular Medicine, 2016
Long‐QT syndrome (LQTS) is an arrhythmogenic disorder characterised by prolongation of the QT interval in the electrocardiogram, which can lead to sudden cardiac death.
Luca Sala, Zhiyi Yu, D. Ward-van Oostwaard, J. V. van Veldhoven, A. Moretti, K. Laugwitz, C. Mummery, A. P. IJzerman, M. Bellin   +8 more
semanticscholar   +1 more source

Electrocardiograpic responses during spontaneous hypoglycaemia in people with type 1 diabetes and impaired awareness of hypoglycaemia

Diabetic Medicine, EarlyView.
Abstract Aims Hypoglycaemia causes abnormal cardiac repolarisation, which has been related to sympathoadrenal activation. We examined whether individuals with type 1 diabetes (T1D) and impaired awareness of hypoglycaemia (IAH) were protected against proarrhythmogenic alterations on their electrocardiogram during clinical episodes of hypoglycaemia ...
Peter Novodvorsky, Alan Bernjak, Ellen Downs, Amelia Smith, Muhammad Fahad Arshad, Andrei I. Oprescu, Richard M. Jacques, Justin Lee, Simon R. Heller, Ahmed Iqbal   +9 more
wiley   +1 more source

Impact of Drug Induced Long QT Syndrome: A Systematic Review

Journal of Clinical Medicine Research, 2018
Background Drug induced long QT syndrome is quite common in daily clinical practice but its impact is unknown. Methods PubMed and EMBASE databases (until May 2, 2017) were searched to identify studies reporting drug induced long QT syndrome and followed ...
K. Arunachalam, Seetha Lakshmanan, A. Maan, Narendra Kumar, Paari Dominic   +4 more
semanticscholar   +1 more source

Autonomic biosignals, seizure detection, and forecasting

Epilepsia, EarlyView.
Abstract Wearable devices have attracted significant attention in epilepsy research in recent years for their potential to enhance patient care through improved seizure monitoring and forecasting. This narrative review presents a detailed overview of the current clinical state of the art while addressing how devices that assess autonomic nervous system
Gadi Miron, Mustafa Halimeh, Jesper Jeppesen, Tobias Loddenkemper, Christian Meisel   +4 more
wiley   +1 more source

Cardiotoxicity induced by Arsenic Trioxide in a patient with acute promyelocytic leukemia. A case report [PDF]

, 2021
Arsenic trioxide has been used in the treatment of acute promyelocytic leukemia with good results in the hematological remission of this malignant hemopathy, but in spite of its effectiveness it can bring various adverse reactions such as cardiotoxicity.
Acuña Caballero, Martha del Carmen, Cabrera Zamora, Maritza Margarita, Cruz Rodríguez, Rodolfo Antonio, Portell Betancourt, Lizmaureen   +3 more
core  

Epilepsy–heart syndrome: Concept, clinical context, and opportunity for integrated care

Epilepsia, EarlyView.
Abstract In this concept paper, we introduce epilepsy‐heart syndrome as a shared burden of illness between epilepsy and cardiac disorders. This pragmatic definition is agnostic of which condition came first (the epilepsy or the cardiac disorder), recognising that these conditions can each serve as a risk factor for the other owing to a bidirectional ...
Gashirai K. Mbizvo, Iain E. Buchan, Anthony G. Marson, Gregory Y. H. Lip   +3 more
wiley   +1 more source