Results 121 to 130 of about 279,908 (354)

Network medicine and systems pharmacology approaches to predicting adverse drug effects

British Journal of Pharmacology, EarlyView.
Identifying and understanding the relationships between drug intake and adverse effects that can occur due to inadvertent molecular interactions between drugs and targets is a difficult task, especially considering the numerous variables that can influence the onset of such events.
Alessio Funari, Giulia Fiscon, Paola Paci   +2 more
wiley   +1 more source

Acquired long QT syndrome in chronic kidney disease patients

Renal Failure, 2019
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired condition that is associated with an increased risk of torsade de pointes (TdP ...
Peng Liu, Lu Wang, Dan Han, Chaofeng Sun, Xiaolin Xue, Guoliang Li   +5 more
semanticscholar   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research: In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome: Development of Chronic Atrioventricular Block Model of Microminipig

Journal of Pharmacological Sciences, 2011
A new in vivo proarrhythmia model of drug-induced long QT syndrome was developed using the Microminipig, an incredibly small minipig established by Fuji Micra Inc. (Shizuoka).
Atsushi Sugiyama, Yuji Nakamura, Yasuki Akie, Hiroyuki Saito, Yasukatsu Izumi, Hiroshi Yamazaki, Naoki Kaneko, Katzuhiko Itoh   +7 more
doaj   +1 more source

Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations

Science Advances, 2017
Long QT syndrome–associated mutations in KCNQ1 most often destabilize the protein, leading to mistrafficking and degradation. Mutations that induce loss of function (LOF) or dysfunction of the human KCNQ1 channel are responsible for susceptibility to a ...
Hui Huang, G. Kuenze, Jarrod A. Smith, K. C. Taylor, A. Duran, Arina Hadziselimovic, J. Meiler, C. Vanoye, A. George, C. Sanders   +9 more
semanticscholar   +1 more source

Prevalence and Duration of Potential Drug–Drug Interactions Among US Nursing Home Residents, 2018–2020

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Nursing home (NH) residents are at increased risk of drug–drug interactions (DDIs) due to multimorbidity and polypharmacy. While prior research suggests that many DDIs lead to adverse drug events in older adults, the extent of exposure to potentially clinically relevant DDIs among United States (US) NH residents is largely unknown ...
Laura A. Reich, Lori A. Daiello, Sarah D. Berry, Adam M. D'Amico, Douglas P. Kiel, Daniel A. Harris, Kaleen N. Hayes, Charles E. Leonard, Yu‐Chia (Sam) Hsu, Andrew R. Zullo   +9 more
wiley   +1 more source

Integration of validated functional evidence to support the pathogenicity of KCNH2 variants

Genetics in Medicine Open
Functional investigation of genetic variants found in long QT syndrome can provide evidence that is needed to confirm the genetic diagnosis and establish the cause of the condition.
Reema W. Aljassar, Qianyi Shen, Buthaina Albash, Jamie I. Vandenberg, Mohammad A. Ebrahim, Chai-Ann Ng   +5 more
doaj   +1 more source

Acute Hypokalemia May Not Be an Effective Way to Sensitize the In Situ Canine Heart for Sparfloxacin-Induced Long QT Syndrome

Journal of Pharmacological Sciences, 2006
.: Extents of the sparfloxacin (3 – 10 mg/kg, i.v.)-induced QT interval prolongation under normokalemic and hypokalemic conditions were assessed in halothane-anesthetized beagle dogs (n = 5).
Katsuyoshi Chiba, Atsushi Sugiyama, Kazuo Watanabe, Kiyoshi Takasuna, Keitaro Hashimoto   +4 more
doaj   +1 more source

Genotype-Phenotype Relationships in Long QT Syndrome : Role of Mental Stress, Adrenergic Activity and a Common KCNH2 Polymorphism [PDF]

, 2006
Long QT syndrome is a congenital or acquired arrhythmic disorder which manifests as a prolonged QT-interval on the electrocardiogram and as a tendency to develop ventricular arrhythmias which can lead to sudden death.
Paavonen, Kristian
core  

The Outcome of Long QT Syndrome: What is the Optimal Therapy?

, 2022
Ji‐Eun Ban
openalex   +1 more source