Results 121 to 130 of about 169,795 (221)

QT-TDM: Planning With Transformer Dynamics Model and Autoregressive Q-Learning [PDF]

open access: yesarXiv
Inspired by the success of the Transformer architecture in natural language processing and computer vision, we investigate the use of Transformers in Reinforcement Learning (RL), specifically in modeling the environment's dynamics using Transformer Dynamics Models (TDMs). We evaluate the capabilities of TDMs for continuous control in real-time planning
arxiv  

Low Penetrance in the Long-QT Syndrome [PDF]

open access: bronze, 1999
Silvia G. Priori   +2 more
openalex   +1 more source

Pharmaceutical prokinetic and surgical interventions have opposing effects on gastroduodenal electromechanical coupling

open access: yesActa Physiologica, Volume 241, Issue 5, May 2025.
Abstract Improper gastric emptying is implicated in several gastrointestinal disorders and may result from disrupted electromechanical coupling of the gastroduodenal junction (GDJ). Rhythmic “slow waves” and myogenic “spikes” are bioelectrical mechanisms that, alongside neural and hormonal co‐factors, control GDJ motility.
Sam Simmonds   +6 more
wiley   +1 more source

Avatrombopag for the Treatment of Immune Thrombocytopenia

open access: yesEuropean Journal of Haematology, Volume 114, Issue 5, Page 733-746, May 2025.
ABSTRACT Avatrombopag, a second‐generation thrombopoietin receptor agonist (TPO‐RA), represents a significant advancement in the treatment of chronic immune thrombocytopenic purpura (cITP) and a potential therapeutic option for other thrombocytopenic disorders.
Caterina Labanca   +11 more
wiley   +1 more source

Acquired Genotype‐Positive Long QT Syndrome After Pediatric Heart Transplantation

open access: yesPediatric Transplantation, Volume 29, Issue 3, May 2025.
ABSTRACT Background Congenital long QT syndrome (LQTS) is rare but significant, as it carries a risk for ventricular arrhythmias and sudden cardiac death. Its diagnosis can be made clinically by serial ECGs, ambulatory ECG monitoring, and exercise stress testing; however, genetic testing is confirmatory in the majority of cases.
Nicholas V. Barresi   +3 more
wiley   +1 more source

Comparative Analysis of Pre-trained Deep Learning Models and DINOv2 for Cushing's Syndrome Diagnosis in Facial Analysis [PDF]

open access: yesarXiv
Cushing's syndrome is a condition caused by excessive glucocorticoid secretion from the adrenal cortex, often manifesting with moon facies and plethora, making facial data crucial for diagnosis. Previous studies have used pre-trained convolutional neural networks (CNNs) for diagnosing Cushing's syndrome using frontal facial images.
arxiv  

Novel missense mutation (G601S) of HERG in a Japanese long QT syndrome family [PDF]

open access: bronze, 1998
Kaoru Akimoto   +7 more
openalex   +1 more source

The apo LETM1 F‐EF‐hand adopts a closed conformation that underlies a multi‐modal sensory role in mitochondria

open access: yesFEBS Letters, Volume 599, Issue 7, Page 971-988, April 2025.
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin   +2 more
wiley   +1 more source

Pueraria mirifica, an estrogenic tropical herb, unveiled the severity of Type 1 LQTS caused by KCNQ1‐T587M

open access: yesJournal of Arrhythmia, 2021
Asami Kashiwa   +7 more
doaj   +1 more source

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