Results 161 to 170 of about 37,848 (274)

Efficacy and safety of zuranolone in Japanese adults with major depressive disorder: A double‐blind, randomized, placebo‐controlled, Phase 3 clinical trial

Psychiatry and Clinical Neurosciences, Volume 80, Issue 1, Page 76-86, January 2026.
Aim To evaluate the efficacy and safety of oral zuranolone for 14 days, compared with placebo, in Japanese patients with major depressive disorder (MDD). Methods This multicenter, Phase 3 study was conducted in two parts (70 sites; Japan) including a randomized, double‐blind, placebo‐controlled, parallel‐group part presented herein.
Masaki Kato, Kazuyuki Nakagome, Takamichi Baba, Takuhiro Sonoyama, Hiroki Fukuju, Ryosuke Shimizu, Juan Carlos Gomez, Tomoko Motomiya, Takeshi Inoue   +8 more
wiley   +1 more source

Inhibitory effect of oestradiol on the cardiac KV7.1/KCNE1 channel is species dependent

Experimental Physiology, Volume 111, Issue 1, Page 54-68, 1 January 2026.
Abstract Oestradiol (17β‐E2) is reported to prolong the cardiac action potential duration and QT interval, in part by affecting cardiac ion channels. Previous studies found inhibiting 17β‐E2 effects on the repolarizating cardiac KV7.1/KCNE1 channel, or its native current, in heterologous expression systems or tissue from animal species.
Veronika A. Linhart, Lucas Dauga, Sara I. Liin   +2 more
wiley   +1 more source

Holter Monitor QT Dispersion and QTc-Dispersion in Pediatric Long QT Syndrome and Development of a Diagnostic and Arrhythmia Risk Prediction Model. [PDF]

J Am Heart Assoc
Allam H, Dang NL, Karasalihovic E, Miller N, Roelle L, Orr WB, Nash D, Pompa AG, Silva JNA.   +8 more
europepmc   +1 more source

Insufficient or Excessive Niacin Intake Induced Glucose and Lipid Metabolic Disorders and Impaired Liver Health in Nile Tilapia

Aquaculture Nutrition, Volume 2026, Issue 1, 2026.
Niacin (vitamin B3) is involved in the metabolic regulation of energy metabolism in animals. However, both deficiency and excess supplementation of niacin can induce profound physiological disturbances in fish. The present study investigated the effect of niacin on energy metabolism and liver health in Nile tilapia (Oreochromis niloticus).
Ruixin Li, Jingwen Liu, Jiayong Liang, Lang Liang, Zexuan Kong, Tan Liu, Xiaojuan Liu, Fan Lin, Cuiying Chen, Zhenyu Du, Shuqi Wang, Mansour Torfi Mozanzadeh   +11 more
wiley   +1 more source

Congenital Long QT Syndrome: A Focus on Risk Stratification and Management. [PDF]

Rev Cardiovasc Med
Ranganathan D, Grondin S, Hadjeres R, Joza J.   +3 more
europepmc   +1 more source

Hope in Miniature: The First Case of Implantation of a “Tiny Pacemaker” in Italy as a Successful Treatment for Congenital Atrioventricular Block in a Low Birth Weight Child

Case Reports in Cardiology, Volume 2026, Issue 1, 2026.
Congenital complete atrioventricular block (CAVB) is a rare cardiac condition occurring in approximately one in 15,000 to one in 22,000 live births. Maternal autoimmune diseases, with anti‐ssA (Ro) and anti‐ssB (La) antibodies implicated in 56%–90% of cases, are primary causes.
Ferrari Paola, Limonta Raul, Malanchini Giovanni, Patanè Luisa, De Filippo Paolo, Karuna Sharma   +5 more
wiley   +1 more source

Perioperative management of thoracoscopic left cardiac sympathetic denervation for refractory long QT syndrome: a case report. [PDF]

JA Clin Rep
Nitta A, Sawada A, Abe K, Kamiyama N, Takahashi Y, Miyajima M, Edanaga M, Yamakage M.   +7 more
europepmc   +1 more source

A Common Mutation of Long QT Syndrome Type 1 in Japan

, 2015
Hideki Itoh, Kenichi Dochi, Wataru Shimizu, Isabelle Denjoy, Seiko Ohno, Takeshi Aiba, Hiromi Kimura, Koichi Kato, Megumi Fukuyama, Kanae Hasagawa, Eric Schulze‐Bahr, Pascale Guicheney, Minoru Horie   +12 more
openalex   +2 more sources

Identification of Two Rare Variants in Iranian Families With Familial Sudden Cardiac Death

International Journal of Genomics, Volume 2026, Issue 1, 2026.
Cellular action potential is characterized by a particular sequence of depolarizing and repolarizing ion currents regulated by ion channels. Genetic mutations in these channels disrupt the essential movement of ions, such as Na+, Ca++, and K+, across the cell membrane, leading to dangerous arrhythmias and sudden cardiac death (SCD).
Mahsa Tahmasebivand, Sepideh Mehvari, Fatemeh Ghodratpour, Hamidreza Khoram Khorshid, Reza Malekzadeh, Reza Najafipour, Yasser Riazalhosseini, Mark Lathrop, Hossein Najmabadi, Kimia Kahrizi, Neetu Rawal   +10 more
wiley   +1 more source

Postpartum QT Prolongation in a Long QT Syndrome Type 1 Patient. [PDF]

Ann Noninvasive Electrocardiol
Wiedenmann LC, Ehrlich JR, Goldenberg I.
europepmc   +1 more source