Results 111 to 120 of about 422,791 (189)

Delivery of Islatravir via High Drug‐Load, Long‐acting Microarray Patches for the Prevention or Treatment of Human Immunodeficiency Virus

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Islatravir‐loaded dissolving microarray patches (MAPs) provide a minimally invasive, long‐acting solution for HIV‐1 prevention and treatment. In rats, sustained islatravir delivery lasts up to three months, while in minipigs, efficacious plasma levels are detected for six days.
Qonita Kurnia Anjani, Ashley R. Johnson, Akmal H. Sabri, Ryan Lutz, Steven Tignor, Jeanine Ballard, Nathan Rudd, Li Zhao, Lalitkumar K. Vora, Stephanie E. Barrett, Angela Wagner, Ryan F. Donnelly   +11 more
wiley   +1 more source

Correction: Detection and classification of long terminal repeat sequences in plant LTR-retrotransposons and their analysis using explainable machine learning. [PDF]

BioData Min
Horvath J, Jedlicka P, Kratka M, Kubat Z, Kejnovsky E, Lexa M.   +5 more
europepmc   +1 more source

Dexamethasone Delivery via Amphiphilic, Low‐swelling Hydrogels Treats Postoperative Inflammation in Cervical Spine Applications

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
DexaPatch, an implantable, low‐swelling amphiphilic hydrogel system containing dexamethasone‐PLGA microparticles, is developed and characterized for sustained local steroid release to reduce postoperative inflammation in tight surgical spaces. DexaPatch significantly reduces postoperative edema and fibrosis in a rabbit model of anterior spinal surgery,
Stephen W. Linderman, Graham F. Barber, S'Dravious A. DeVeaux, Edward A. Botchwey, Daniel Refai, Adam M. Klein, Andrés J. García   +6 more
wiley   +1 more source

Detection and classification of long terminal repeat sequences in plant LTR-retrotransposons and their analysis using explainable machine learning. [PDF]

BioData Min
Horvath J, Jedlicka P, Kratka M, Kubat Z, Kejnovsky E, Lexa M.   +5 more
europepmc   +1 more source

Identification of high-copy number long terminal repeat retrotransposons and their expansion in Phalaenopsis orchids. [PDF]

BMC Genomics, 2020
Hsu CC, Chen SY, Lai PH, Hsiao YY, Tsai WC, Liu ZJ, Chung MC, Panaud O, Chen HH.   +8 more
europepmc   +1 more source

Engineered 3D Kidney Glomerular Microtissues to Model Podocyte‐Centric Diseases for the Validation of New Drug Targets

Advanced Healthcare Materials, EarlyView.
The study introduces innovative 3D microtissues that replicate the glomerular filtration barrier of the kidney, offering a novel platform for understanding podocytopathies. These microtissues simulate the glomerulus's structure and dynamics, allowing for the modeling of podocyte injuries and drug testing.
Sara Buttό, Solange Vidal, Xi Rui Zeng, Martin Rausch, Immihan Ceren Yasa, Magali P. Ferro   +5 more
wiley   +1 more source

DANTE and DANTE_LTR: lineage-centric annotation pipelines for long terminal repeat retrotransposons in plant genomes. [PDF]

NAR Genom Bioinform
Novák P, Hoštáková N, Neumann P, Macas J.   +3 more
europepmc   +1 more source

Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response

Advanced Healthcare Materials, EarlyView.
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim, Jin Woong Lee, Piper A. Rawding, Mari Iida, Carter Kim, Kourtney L. Kostecki, Michael J. Poellmann, Bridget Crossman, Ashley S. Liu, YoungSoo Kim, Deric L. Wheeler, Seungpyo Hong   +11 more
wiley   +1 more source

Development of a latency model for HIV-1 subtype C and the impact of long terminal repeat element genetic variation on latency reversal. [PDF]

J Virus Erad
Maikoo S, Palstra RJ, Dong KL, Mahmoudi T, Ndung'u T, Madlala P.   +5 more
europepmc   +1 more source

Long terminal repeat retrotransposons jump between species [PDF]

Alberola, Biessmann, Blackman, Bucheton, Cho, Daniels, Engels, Finnegan, Flavell, Garfinkel, Hamada, Hartl, Heath, Houck, Jordan, Kazazian, Kim, Kordis, Marracci, Maruyama, Miller, Mount, SanMiguel, Sheen, Shiba, Smit, Xiong   +26 more
core   +1 more source