Matrix: a complex amalgam of structures and functions in tumor microenvironment
FEBS Open Bio, EarlyView.The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis +3 more
wiley +1 more source
CD9‐association with PIP2 areas is regulated by a CD9 salt bridge
FEBS Open Bio, EarlyView.The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi +2 more
wiley +1 more source
Bio-Protocol, 2015 Almost all individuals infected with human immunodeficiency virus (HIV) are also infected with cytomegalovirus (CMV) and Epstein Barr virus (EBV).
Marta Massanella +4 more
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Different relative expression from two murine leukemia virus long terminal repeats in unintegrated transfected DNA and in integrated retroviral vector proviruses [PDF]
, 1989 Kirsten Paludan +5 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Malignant gliomas pose significant therapeutic challenges. This study aimed to identify and characterize a novel chimeric RNA in glioma and assess its clinical and functional significance for precision treatment. Methods The C19orf47‐AKT2 chimeric RNAs were identified through RNA sequencing and validated by polymerase chain reaction.
Zihan Wang +11 more
wiley +1 more source
Activation of NF‐κB Signaling by Optogenetic Clustering of IKKα and β
Advanced Biology, EarlyView.This study presents an optogenetic approach for graded clustering of eGFP‐fused proteins using an eGFP‐specific nanobody and engineered Cryptochrome 2 variants. The method enables potent, reversible activation of NF‐κB signaling via endogenous pathways, as confirmed by RNA sequencing. This versatile system provides a spatially and temporally controlled
Alexandra Anna Maria Fischer +8 more
wiley +1 more source
Genetic variation of the HIV-1 subtype C transmitted/founder viruses long terminal repeat elements and the impact on transcription activation potential and clinical disease outcomes. [PDF]
PLoS Pathog, 2023 Madlala P +7 more
europepmc +2 more sources
Bioinformatic Annotation of Transposon DNA Processing Genes on the Long-Read Genome Assembly of s
Bioinformatics and Biology InsightsTransposable elements (TEs) or transposons are thought to play roles in animal physiological processes, such as germline, early embryonic, and brain development, as well as aging.
Yukinobu Arata +3 more
doaj +1 more source
Origin and Evolution of Plant Long Terminal Repeat Retrotransposons with Additional Ribonuclease H. [PDF]
Genome Biol Evol, 2023 Biryukov M, Ustyantsev K.
europepmc +1 more source
Rearrangements in the Long Terminal Repeat of Extra Mouse Mammary Tumor Proviruses in T-Cell Leukemias of Mouse Strain GR Result in a Novel Enhancer-Like Structure [PDF]
, 1985 Rob Michalides +2 more
openalex +1 more source