Results 11 to 20 of about 625,763 (148)

Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions [PDF]

Mobile DNA, 2010
Non-long terminal repeat (non-LTR) retrotransposons are present in most eukaryotic genomes. In some species, such as humans, these elements are the most abundant genome sequence and continue to replicate to this day, creating a source of endogenous ...
Han, Jeffrey S
core   +5 more sources

LtrDetector: A tool-suite for detecting long terminal repeat retrotransposons de-novo

BMC Genomics, 2019
Background Long terminal repeat retrotransposons are the most abundant transposons in plants. They play important roles in alternative splicing, recombination, gene regulation, and defense mechanisms. Large-scale sequencing projects for plant genomes are
Joseph D. Valencia, Hani Z. Girgis
doaj   +2 more sources

LTR_FINDER_parallel: parallelization of LTR_FINDER enabling rapid identification of long terminal repeat retrotransposons

Mobile DNA, 2019
Annotation of plant genomes is still a challenging task due to the abundance of repetitive sequences, especially long terminal repeat (LTR) retrotransposons.
Shujun Ou, Ning Jiang
doaj   +2 more sources

Comparative analysis of miniature inverted–repeat transposable elements (MITEs) and long terminal repeat (LTR) retrotransposons in six Citrus species

BMC Plant Biology, 2019
Background Miniature inverted-repeat transposable elements (MITEs) and long terminal repeat (LTR) retrotransposons are ubiquitous in plants genomes, and highly important in their evolution and diversity.
Yan Liu, Muhammad Tahir ul Qamar, Jia-Wu Feng, Yuduan Ding, Shuo Wang, Guizhi Wu, Lingjun Ke, Qiang Xu, Ling-Ling Chen   +8 more
doaj   +2 more sources

Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome [PDF]

Nucleic Acids Research, 2016
open8The long terminal repeat (LTR) of the proviral human immunodeficiency virus (HIV)-1 genome is integral to virus transcription and host cell infection.
Beatrice De Nicola, C. J. Lech, B. Heddi, Sagar Regmi, Ilaria Frasson, Rosalba Perrone, S. Richter, A. Phan   +7 more
core   +2 more sources

Conserved presence of G-quadruplex forming sequences in the Long Terminal Repeat Promoter of Lentiviruses [PDF]

Scientific Reports, 2017
G-quadruplexes (G4s) are secondary structures of nucleic acids that epigenetically regulate cellular processes. In the human immunodeficiency lentivirus 1 (HIV-1), dynamic G4s are located in the unique viral LTR promoter.
A Ayouba, A Henderson, A Rambaut, AK Todd, AM Fleming, AN Lane, AR Haeusler, B Berkhout, B Zhou, BF Keele, D Piekna-Przybylska, D Qu, D Rhodes, D Sen, DJ Patel, E Tosoni, EA Raiber, F Barre-Sinoussi, F Benachenhou, F Bibollet-Ruche, F Heuverswyn Van, F Turrini, G Biffi, GE Crooks, IT Holder, J Felsenstein, J Norseen, J Qiu, J Song, J Yamaguchi, JE Clements, JF Fisette, JP Taylor, K Tamura, K Tluckova, KA Jones, LA Pereira, M Fry, M Metifiot, M Sala, M Scalabrin, MA Larkin, N Maizels, ND Perkins, NH Campbell, P Fratta, P Ivanov, P Murat, P Sket, R Perrone, R Perrone, R Perrone, R Perrone, RC Edgar, RC Gallo, RJ Gifford, S Amrane, S Artusi, S Artusi, S Balasubramanian, S Bhatia, S Broos, S Burge, S Pohlmann, SE Tong-Starksen, SR Wang, SR Wang, Y Wang   +67 more
core   +2 more sources

Synthesis, Binding and Antiviral Properties of Potent Core-Extended Naphthalene Diimides Targeting the HIV-1 Long Terminal Repeat Promoter G-Quadruplexes [PDF]

Journal of Medicinal Chemistry, 2015
We have previously reported that stabilization of the G-quadruplex structures in the HIV-1 long terminal repeat (LTR) promoter suppresses viral transcription.
Botti, Silvia, Butovskaya, Elena, Doria, Filippo, Frasson, Ilaria, Freccero, Mauro, Grande, Vincenzo, Lago, Sara, Nadai, Matteo, Perrone, Rosalba, Richter, Sara, Scalabrin, Matteo   +10 more
core   +2 more sources

Ginger DNA transposons in eukaryotes and their evolutionary relationships with long terminal repeat retrotransposons

Mobile DNA, 2010
Background In eukaryotes, long terminal repeat (LTR) retrotransposons such as Copia, BEL and Gypsy integrate their DNA copies into the host genome using a particular type of DDE transposase called integrase (INT).
Bao Weidong, Kapitonov Vladimir V, Jurka Jerzy   +2 more
doaj   +2 more sources

Overlapping enhancer/promoter and transcriptional termination signals in the lentiviral long terminal repeat [PDF]

Retrovirology, 2007
Oncoretrovirus, but not lentivirus, displays a high transcriptional readthrough activity in the 3' long terminal repeat (LTR) (Zaiss et al. J. Virol. 76, 7209–7219, 2002). However, the U3-deleted, self-inactivating (SIN) lentiviral LTR also exhibits high
Chang, Lung-Ji, Lucas, Aurore, Son, Sodany, Yang, Qing   +3 more
core   +5 more sources

Stable and Conserved G-Quadruplexes in the Long Terminal Repeat Promoter of Retroviruses [PDF]

ACS Infectious Diseases, 2019
Retroviruses infect almost all vertebrates, from humans to domestic and farm animals, from primates to wild animals, where they cause severe diseases, including immunodeficiencies, neurological disorders, and cancer.
Nadai, Matteo, Perrone, Rosalba, Richter, Sara N., Ruggiero, Emanuela, Tassinari, Martina   +4 more
core   +3 more sources