Results 41 to 50 of about 330,554 (315)

Long terminal repeat retrotransposons jump between species [PDF]

Proceedings of the National Academy of Sciences, 1999
Retrotransposons are an evolutionarily ancient class of mobile genetic elements that transpose replicatively within their host genomes via RNA intermediates. There are three major retrotransposon groups, the Ty1-copia group and the gypsy group long terminal repeat (LTR) retrotransposons and the non-LTR retrotransposons or LINE elements (ref. 1; Fig. 1).
openaire   +3 more sources

Characterization of equine infectious anemia virus long terminal repeat [PDF]

Journal of Virology, 1987
The long terminal repeats (LTRs) of equine infectious anemia virus (EIAV) were examined with respect to their ability to function as transcriptional promoters in various cellular environments. Nucleotide sequence analyses of the LTRs derived from two unique proviral clones revealed the requisite consensus transcription and processing signals.
Robert M. Stephens, Nancy R. Rice, Patricia L. Dorn, D Derse, L Levy, J. W. Casey   +5 more
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Synthesis, Binding and Antiviral Properties of Potent Core-Extended Naphthalene Diimides Targeting the HIV-1 Long Terminal Repeat Promoter G-Quadruplexes

Journal of Medicinal Chemistry, 2015
We have previously reported that stabilization of the G-quadruplex structures in the HIV-1 long terminal repeat (LTR) promoter suppresses viral transcription.
Rosalba Perrone, F. Doria, E. Butovskaya, Ilaria Frasson, S. Botti, M. Scalabrin, Sara Lago, Vincenzo Grande, M. Nadai, M. Freccero, S. Richter   +10 more
semanticscholar   +1 more source

Nucleotide sequences of the retroviral long terminal repeats and their adjacent regions [PDF]

Nucleic Acids Research, 1984
The nucleotide sequences of the LTRs and their adjacent regions from 19 type C and one type B retrovirus were compared. Salient features are: (a) The R regions in the genomes of most of the type C retroviruses begin with GC and end with CA. (b) The mammalian type C retroviruses have a polyadenylation signal "AATAAA" in the R region, and most have a ...
H. R. Chen, Winona C. Barker
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Amplification of LTRs of extrachromosomal linear DNAs (ALE-seq) identifies two active Oryco LTR retrotransposons in the rice cultivar Dongjin

Mobile DNA, 2022
Long terminal repeat retrotransposons (LTR-RTs) make up a considerable portion of plant genomes. New insertions of these active LTR-RTs modify gene structures and functions and play an important role in genome evolution.
Hyunjin Koo, Soomin Kim, Hyun-Seung Park, Sang-Ji Lee, Nam-Chon Paek, Jungnam Cho, Tae-Jin Yang   +6 more
doaj   +1 more source

Increase in 2-long terminal repeat circles and decrease in D-dimer after raltegravir intensification in patients with treated HIV infection: a randomized, placebo-controlled trial.

Journal of Infectious Diseases, 2013
BACKGROUND The degree to which human immunodeficiency virus (HIV) continues to replicate during antiretroviral therapy (ART) is controversial. We conducted a randomized, double-blind, placebo-controlled study to assess whether raltegravir intensification
H. Hatano, M. Strain, R. Scherzer, P. Bacchetti, D. Wentworth, R. Hoh, Jeffrey N. Martin, J. McCune, J. Neaton, R. Tracy, P. Hsue, D. Richman, S. Deeks   +12 more
semanticscholar   +1 more source

Helquat dyes targeting G-quadruplexes as a new class of anti-HIV-1 inhibitors

Scientific Reports, 2023
The secondary structure of nucleic acids containing quartets of guanines, termed G-quadruplexes, is known to regulate the transcription of many genes.
Marcela Pávová, Paul Eduardo Reyes-Gutiérrez, Jaroslav Kozák, Juraj Dobiaš, Yevgen Yurenko, Martin Lepšík, Filip Teplý, Jan Weber   +7 more
doaj   +1 more source

Nucleotide sequence analysis of the long terminal repeat of integrated simian sarcoma virus: evolutionary relationship with other mammalian retroviral long terminal repeats [PDF]

Journal of Virology, 1982
Nucleotide sequence analysis of the long terminal repeat (LTR) of the integrated simian sarcoma virus showed that the simian sarcoma virus LTR comprised 504 nucleotides with an inverted repeat of seven bases at its 5' and 3' termini. At the site of simian sarcoma virus integration, cellular flanking sequences adjacent to the proviral LTR contained a ...
E P Reddy, Stuart A. Aaronson, Sushilkumar G. Devare, J D Law   +3 more
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A dynamic G-quadruplex region regulates the HIV-1 long terminal repeat promoter.

Journal of Medicinal Chemistry, 2013
G-Quadruplexes, noncanonical nucleic acid structures, act as silencers in the promoter regions of human genes; putative G-quadruplex forming sequences are also present in promoters of other mammals, yeasts, and prokaryotes. Here we show that also the HIV-
Rosalba Perrone, M. Nadai, Ilaria Frasson, Jerrod A. Poe, E. Butovskaya, T. Smithgall, M. Palumbo, G. Palù, S. Richter   +8 more
semanticscholar   +1 more source

Conserved presence of G-quadruplex forming sequences in the Long Terminal Repeat Promoter of Lentiviruses

Scientific Reports, 2017
G-quadruplexes (G4s) are secondary structures of nucleic acids that epigenetically regulate cellular processes. In the human immunodeficiency lentivirus 1 (HIV-1), dynamic G4s are located in the unique viral LTR promoter.
Rosalba Perrone, Enrico Lavezzo, Giorgio Palù, Sara N. Richter   +3 more
doaj   +1 more source