Results 21 to 30 of about 249,382 (229)
Structural Change in Urban Systems [PDF]
, 1983 This paper outlines a conceptual background for understanding the dynamics of metropolitan regions and urban systems in general. An essential part of the paper reviews existing theoretical explanations of urban change processes with special attention ...
Nijkamp, P., Schubert, U.
core
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source
Annals of the University of Oradea: Economic ScienceToday’s business world is highly dynamic, volatile, uncertain, complex, and ambiguous (VUCA). It is driven by ever faster, more efficient, and more numerous technological advances.
Alexandra–Daniela SIVULCA +3 more
doaj +1 more source
Long Waves, Technology Diffusion, and Substitution [PDF]
, 1991 There is an urgent need to drastically reduce adverse environmental impacts resulting from prevailing economic activities. Even more important is the question of the future direction of economic development and technological changes.
Grubler, A., Nakicenovic, N.
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen +7 more
wiley +1 more source
Sunk costs and the dynamics of creative industries [PDF]
, 2012 This chapter examines the long-run evolution of modern entertainment industries such as the film and music industries. It investigates ways to conceptualise and quantify the subsequent waves of creative destruction, and investigates specifically how sunk
Bakker, Gerben
core +1 more source
Advanced Engineering Materials, EarlyView.It is shown that laser ablation pretreatment under oxygen‐free conditions enables copper–aluminium bonding at significantly lower deformation degrees and improved properties compared to mechanical brushing. Laser ablation further increases interface contact area and induces favourable residual stress states and microstructural compatibility ...
Khemais Barienti +11 more
wiley +1 more source
The Benefits and Harms of Transmitting Into Space
, 2013 Deliberate and unintentional radio transmissions from Earth propagate into space. These transmissions could be detected by extraterrestrial watchers over interstellar distances.
Abe +81 more
core +1 more source