Results 1 to 10 of about 368,199 (208)
Distinct longevity mechanisms across and within species and their association with aging
Cell, 2023 SUMMARY Lifespan varies within and across species, but the general principles of its control remain unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species, identifying longevity signatures and examining their relationship ...
A. Tyshkovskiy +12 more
exaly +2 more sources
The Lancet Healthy Longevity, 2021 As the demographic transition enters a new stage of a longevity transition, focus needs to extend beyond an ageing society towards a longevity society. An ageing society focuses on changes in the age structure of the population, whereas a longevity society seeks to exploit the advantages of longer lives through changes in how we age.
Andrew J. Scott
openaire +4 more sources
New Phytologist, 2021 SummaryLarge, majestic trees are iconic symbols of great age among living organisms. Published evidence suggests that trees do not die because of genetically programmed senescence in their meristems, but rather are killed by an external agent or a disturbance event.
Gianluca Piovesan, Franco Biondi
openaire +4 more sources
Lipid metabolism and lipid signals in aging and longevity
Developmental Cell, 2021 SUMMARY Lipids play crucial roles in regulating aging and longevity. In the past few decades, a series of genetic pathways have been discovered to regulate lifespan in model organisms.
Ayse Sena Mutlu, Meng C Wang
exaly +2 more sources
Autophagy as a promoter of longevity: insights from model organisms
Nature Reviews Molecular Cell Biology, 2018 Autophagy is a conserved process that catabolizes intracellular components to maintain energy homeostasis and to protect cells against stress. Autophagy has crucial roles during development and disease, and evidence accumulated over the past decade ...
Malene Hansen +2 more
exaly +2 more sources
A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice
Cell Metabolism, 2017 Summary Calorie restriction, without malnutrition, has been shown to increase lifespan and is associated with a shift away from glycolysis toward beta-oxidation.
Alexey A Tomilov +2 more
exaly +2 more sources
Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy
Cell Metabolism, 2017 Summary Cancer immunotherapy is an increasingly successful strategy for the treatment of patients who have advanced or conventional therapy-resistant cancers.
Rigel J Kishton +2 more
exaly +2 more sources
Biomarkers of Aging for the Identification and Evaluation of Longevity Interventions
Cell, 2023 With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field.
M. Moqri +26 more
semanticscholar +1 more source
Molecular mechanisms of dietary restriction promoting health and longevity
Nature reviews. Molecular cell biology, 2021 Dietary restriction with adequate nutrition is the gold standard for delaying ageing and extending healthspan and lifespan in diverse species, including rodents and non-human primates.
Cara L. Green +2 more
semanticscholar +1 more source