Results 1 to 10 of about 645,076 (372)

Maximum Market Price of Longevity Risk under Solvency Regimes: The Case of Solvency II. [PDF]

, 2017
Longevity risk constitutes an important risk factor for life insurance companies, and it can be managed through longevity-linked securities. The market of longevity-linked securities is at present far from being complete and does not allow finding a ...
LEVANTESI, Susanna, Menzietti, M.
core   +4 more sources

An unsupervised learning approach to identify novel signatures of health and disease from multimodal data

Genome Medicine, 2020
Background Modern medicine is rapidly moving towards a data-driven paradigm based on comprehensive multimodal health assessments. Integrated analysis of data from different modalities has the potential of uncovering novel biomarkers and disease ...
Ilan Shomorony, Elizabeth T. Cirulli, Lei Huang, Lori A. Napier, Robyn R. Heister, Michael Hicks, Isaac V. Cohen, Hung-Chun Yu, Christine Leon Swisher, Natalie M. Schenker-Ahmed, Weizhong Li, Karen E. Nelson, Pamila Brar, Andrew M. Kahn, Timothy D. Spector, C. Thomas Caskey, J. Craig Venter, David S. Karow, Ewen F. Kirkness, Naisha Shah   +19 more
doaj   +1 more source

A novel benchmark for COVID-19 pandemic testing effectiveness enables the accurate prediction of new Intensive Care Unit admissions

Scientific Reports, 2021
The positivity rate of testing is currently used both as a benchmark of testing adequacy and for assessing the evolution of the COVID-19 pandemic. However, since the former is a prerequisite for the latter, its interpretation is often conflicting.
Dimitris Nikoloudis, Dimitrios Kountouras, Asimina Hiona   +2 more
doaj   +1 more source

Adapting Blood DNA Methylation Aging Clocks for Use in Saliva Samples With Cell-type Deconvolution

Frontiers in Aging, 2021
DeepMAge is a deep-learning DNA methylation aging clock that measures the organismal pace of aging with the information from human epigenetic profiles.
Fedor Galkin, Kirill Kochetov, Polina Mamoshina, Alex Zhavoronkov, Alex Zhavoronkov, Alex Zhavoronkov   +5 more
doaj   +1 more source

Longevity and mortality of cats attending primary care veterinary practices in England [PDF]

, 2014
Enhanced knowledge on longevity and mortality in cats should support improved breeding, husbandry, clinical care and disease prevention strategies. The VetCompass research database of primary care veterinary practice data offers an extensive resource of ...
Bessant C, Dohoo I, Elliott J, Gough A, Kirkwood BR, Lulich J, McGreevy PD, McGreevy PD, Nicholas FW, Rochlitz I, Rollin BE, VetCompass   +11 more
core   +2 more sources

Still living with mortality: The longevity risk transfer market after one decade [PDF]

, 2019
This paper updates Living with Mortality published in 2006. It describes how the longevity risk transfer market has developed over the intervening period, and, in particular, how insurance-based solutions – buy-outs, buy-ins and longevity insurance ...
Biffis, Blake, Brouhns, Brouhns, Cairns, Cairns, Chen, Czado, Danesi, Dowd, Gourieroux, Gourieroux, Haberman, Haberman, Haberman, Haberman, Hainaut, Hari, Hatzopoulos, Hatzopoulos, Hunt, Hunt, Jarner, Kleinow, Koissi, Lee, Li, Li, Li, Lin, Loeys, Mitchell, Plat, Renshaw, Renshaw, Renshaw, Russo, Yang   +37 more
core   +2 more sources

Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function

Communications Biology, 2022
TrxR2 overexpression in mice enhances metabolism and prevents high-fat diet induced metabolic deficits in mice through alteration in function of several enzymes in the tricarboxylic acid cycle and complexes of the electron transport chain.
E. Sandra Chocron, Kennedy Mdaki, Nisi Jiang, Jodie Cropper, Andrew M. Pickering   +4 more
doaj   +1 more source

Ironing out exercise on immuno-oncological outcomes

Journal for ImmunoTherapy of Cancer, 2022
Despite accumulating evidence that supports the beneficial effects of physical exercise in inhibiting cancer progression, whether exercise modulates its effects through systemic and cellular changes in iron metabolism and immune-tumor crosstalk is ...
Elaine Hsuen Lim, Janjira Soh, Zi Xiang Lim, Brian K Kennedy, Jorming Goh   +4 more
doaj   +1 more source

Delayed Germination of Seeds: A Look at the Effects of Adult Longevity, the Timing of Reproduction, and Population Age/Stage Structure [PDF]

, 1994
The effects of adult longevity, the timing of reproduction, and population age/stage structure on the evolution of seed dormancy are explored in both constant and variable environment models. In the constant environment models complete germination is the
Rees, M.
core   +1 more source

Longevity and mortality of owned dogs in England [PDF]

, 2013
Improved understanding of longevity represents a significant welfare opportunity for the domestic dog, given its unparalleled morphological diversity.
Brodbelt, D C, Church, D B, McGreevy, P D, O'Neill, D G, Sydney, Thomson, P C   +5 more
core   +2 more sources