Results 1 to 10 of about 730,309 (342)

An unsupervised learning approach to identify novel signatures of health and disease from multimodal data

open access: yesGenome Medicine, 2020
Background Modern medicine is rapidly moving towards a data-driven paradigm based on comprehensive multimodal health assessments. Integrated analysis of data from different modalities has the potential of uncovering novel biomarkers and disease ...
Ilan Shomorony   +19 more
doaj   +1 more source

A novel benchmark for COVID-19 pandemic testing effectiveness enables the accurate prediction of new Intensive Care Unit admissions

open access: yesScientific Reports, 2021
The positivity rate of testing is currently used both as a benchmark of testing adequacy and for assessing the evolution of the COVID-19 pandemic. However, since the former is a prerequisite for the latter, its interpretation is often conflicting.
Dimitris Nikoloudis   +2 more
doaj   +1 more source

Adapting Blood DNA Methylation Aging Clocks for Use in Saliva Samples With Cell-type Deconvolution

open access: yesFrontiers in Aging, 2021
DeepMAge is a deep-learning DNA methylation aging clock that measures the organismal pace of aging with the information from human epigenetic profiles.
Fedor Galkin   +5 more
doaj   +1 more source

Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function

open access: yesCommunications Biology, 2022
TrxR2 overexpression in mice enhances metabolism and prevents high-fat diet induced metabolic deficits in mice through alteration in function of several enzymes in the tricarboxylic acid cycle and complexes of the electron transport chain.
E. Sandra Chocron   +4 more
doaj   +1 more source

Ironing out exercise on immuno-oncological outcomes

open access: yesJournal for ImmunoTherapy of Cancer, 2022
Despite accumulating evidence that supports the beneficial effects of physical exercise in inhibiting cancer progression, whether exercise modulates its effects through systemic and cellular changes in iron metabolism and immune-tumor crosstalk is ...
Elaine Hsuen Lim   +4 more
doaj   +1 more source

Utilization of defined microbial communities enables effective evaluation of meta-genomic assemblies

open access: yesBMC Genomics, 2017
Background Metagenomics is the study of the microbial genomes isolated from communities found on our bodies or in our environment. By correctly determining the relation between human health and the human associated microbial communities, novel mechanisms
William W. Greenwald   +7 more
doaj   +1 more source

Correlates of estimated lifetime cruciate ligament survival inform potential rupture risk reduction strategies: findings from the Exceptional Aging in Rottweilers Study

open access: yesScientific Reports, 2023
Cranial cruciate ligament (CCL) rupture is one of the most commonly diagnosed orthopedic conditions of pet dogs, making estimated lifetime cruciate ligament survival an attractive endpoint for studies attempting to define clinical and genetic correlates ...
David J. Waters   +6 more
doaj   +1 more source

A multiple technology-based physical activity intervention for Latina adolescents in the USA: randomized controlled trial study protocol for Chicas Fuertes

open access: yesTrials, 2022
Background Latina adolescents in the USA report some of the lowest rates of physical activity of any demographic subgroup; this is paralleled by a markedly higher lifetime risk of obesity, type 2 diabetes, and other conditions related to inactivity ...
Britta Larsen   +8 more
doaj   +1 more source

Changes in insulin, adiponectin and lipid concentrations with age are associated with frailty and reduced quality of life in dogs

open access: yesScientific Reports
Declining metabolic function with aging is a conserved phenotype across many species. While aging-associated changes in metabolic status have been investigated rigorously in humans, less is known about metabolic aging in dogs.
Brennen McKenzie   +17 more
doaj   +1 more source

Translational immune and metabolic markers of aging in dogs

open access: yesScientific Reports
Dogs serve as a promising aging model due to their genetic diversity, condensed lifespan, and shared living environment with humans. Alterations in the immune and metabolic parameters are hallmarks of aging in humans, but few studies have investigated ...
James E. McMahon   +9 more
doaj   +1 more source

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