Results 1 to 10 of about 223,650 (307)

An unsupervised learning approach to identify novel signatures of health and disease from multimodal data

Genome Medicine, 2020
Background Modern medicine is rapidly moving towards a data-driven paradigm based on comprehensive multimodal health assessments. Integrated analysis of data from different modalities has the potential of uncovering novel biomarkers and disease ...
Ilan Shomorony, Elizabeth T. Cirulli, Lei Huang, Lori A. Napier, Robyn R. Heister, Michael Hicks, Isaac V. Cohen, Hung-Chun Yu, Christine Leon Swisher, Natalie M. Schenker-Ahmed, Weizhong Li, Karen E. Nelson, Pamila Brar, Andrew M. Kahn, Timothy D. Spector, C. Thomas Caskey, J. Craig Venter, David S. Karow, Ewen F. Kirkness, Naisha Shah   +19 more
doaj   +1 more source

A set of common buccal CpGs that predict epigenetic age and associate with lifespan-regulating genes

iScience, 2022
Summary: Epigenetic aging clocks are computational models that use DNA methylation sites to predict age. Since cheek swabs are non-invasive and painless, collecting DNA from buccal tissue is highly desirable.
Adiv A. Johnson, Nicole S. Torosin, Maxim N. Shokhirev, Trinna L. Cuellar   +3 more
doaj   +1 more source

A novel benchmark for COVID-19 pandemic testing effectiveness enables the accurate prediction of new Intensive Care Unit admissions

Scientific Reports, 2021
The positivity rate of testing is currently used both as a benchmark of testing adequacy and for assessing the evolution of the COVID-19 pandemic. However, since the former is a prerequisite for the latter, its interpretation is often conflicting.
Dimitris Nikoloudis, Dimitrios Kountouras, Asimina Hiona   +2 more
doaj   +1 more source

Adapting Blood DNA Methylation Aging Clocks for Use in Saliva Samples With Cell-type Deconvolution

Frontiers in Aging, 2021
DeepMAge is a deep-learning DNA methylation aging clock that measures the organismal pace of aging with the information from human epigenetic profiles.
Fedor Galkin, Kirill Kochetov, Polina Mamoshina, Alex Zhavoronkov, Alex Zhavoronkov, Alex Zhavoronkov   +5 more
doaj   +1 more source

Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function

Communications Biology, 2022
TrxR2 overexpression in mice enhances metabolism and prevents high-fat diet induced metabolic deficits in mice through alteration in function of several enzymes in the tricarboxylic acid cycle and complexes of the electron transport chain.
E. Sandra Chocron, Kennedy Mdaki, Nisi Jiang, Jodie Cropper, Andrew M. Pickering   +4 more
doaj   +1 more source

Ironing out exercise on immuno-oncological outcomes

Journal for ImmunoTherapy of Cancer, 2022
Despite accumulating evidence that supports the beneficial effects of physical exercise in inhibiting cancer progression, whether exercise modulates its effects through systemic and cellular changes in iron metabolism and immune-tumor crosstalk is ...
Elaine Hsuen Lim, Janjira Soh, Zi Xiang Lim, Brian K Kennedy, Jorming Goh   +4 more
doaj   +1 more source

Correlates of estimated lifetime cruciate ligament survival inform potential rupture risk reduction strategies: findings from the Exceptional Aging in Rottweilers Study

Scientific Reports, 2023
Cranial cruciate ligament (CCL) rupture is one of the most commonly diagnosed orthopedic conditions of pet dogs, making estimated lifetime cruciate ligament survival an attractive endpoint for studies attempting to define clinical and genetic correlates ...
David J. Waters, Rong Fu, Andres E. Carrillo, Emily C. Chiang, Aimee H. Maras, Seema S. Kengeri, Cheri L. Suckow   +6 more
doaj   +1 more source

Utilization of defined microbial communities enables effective evaluation of meta-genomic assemblies

BMC Genomics, 2017
Background Metagenomics is the study of the microbial genomes isolated from communities found on our bodies or in our environment. By correctly determining the relation between human health and the human associated microbial communities, novel mechanisms
William W. Greenwald, Niels Klitgord, Victor Seguritan, Shibu Yooseph, J. Craig Venter, Chad Garner, Karen E. Nelson, Weizhong Li   +7 more
doaj   +1 more source

Changes in insulin, adiponectin and lipid concentrations with age are associated with frailty and reduced quality of life in dogs

Scientific Reports
Declining metabolic function with aging is a conserved phenotype across many species. While aging-associated changes in metabolic status have been investigated rigorously in humans, less is known about metabolic aging in dogs.
Brennen McKenzie, Matthew Peloquin, Jessica L. Graves, Frances Chen, Ashley Tovar, Tennery A. Carttar, Katya Tucker, Kenny Vo, Michelle Nelson, Kaitlyn M. Super, Jessica Austriaco, Sunny Y. Weber, Alexander Naka, Erin E. McCandless, Karen Greenwood, Dina Juarez-Salinas, Celine-Lea Halioua-Haubold, Ellen R. Ratcliff   +17 more
doaj   +1 more source

Translational immune and metabolic markers of aging in dogs

Scientific Reports
Dogs serve as a promising aging model due to their genetic diversity, condensed lifespan, and shared living environment with humans. Alterations in the immune and metabolic parameters are hallmarks of aging in humans, but few studies have investigated ...
James E. McMahon, Jessica L. Graves, Ashley P. Tovar, Matthew Peloquin, Karen Greenwood, Frances L. Chen, Michelle Nelson, Erin E. McCandless, Celine-Lea Halioua-Haubold, Dina Juarez-Salinas   +9 more
doaj   +1 more source