Results 1 to 10 of about 770,943 (358)

Maximum Market Price of Longevity Risk under Solvency Regimes: The Case of Solvency II. [PDF]

, 2016
Longevity risk constitutes an important risk factor for life insurance companies, and it can be managed through longevity-linked securities. The market of longevity-linked securities is at present far from being complete and does not allow finding a ...
Helena Leino-Kilpi (3471101), Kirsti Torniainen (3471098), Maija Hupli (3471095), Pauli Puukka (3471104), Risto Huupponen (123670), Virpi Sulosaari (3471107)   +5 more
core   +7 more sources

An unsupervised learning approach to identify novel signatures of health and disease from multimodal data

Genome Medicine, 2020
Background Modern medicine is rapidly moving towards a data-driven paradigm based on comprehensive multimodal health assessments. Integrated analysis of data from different modalities has the potential of uncovering novel biomarkers and disease ...
Ilan Shomorony, Elizabeth T. Cirulli, Lei Huang, Lori A. Napier, Robyn R. Heister, Michael Hicks, Isaac V. Cohen, Hung-Chun Yu, Christine Leon Swisher, Natalie M. Schenker-Ahmed, Weizhong Li, Karen E. Nelson, Pamila Brar, Andrew M. Kahn, Timothy D. Spector, C. Thomas Caskey, J. Craig Venter, David S. Karow, Ewen F. Kirkness, Naisha Shah   +19 more
doaj   +1 more source

Longevity and mortality of cats attending primary care veterinary practices in England [PDF]

, 2014
Enhanced knowledge on longevity and mortality in cats should support improved breeding, husbandry, clinical care and disease prevention strategies. The VetCompass research database of primary care veterinary practice data offers an extensive resource of ...
Bessant C, Dohoo I, Elliott J, Gough A, Kirkwood BR, Lulich J, McGreevy PD, McGreevy PD, Nicholas FW, Rochlitz I, Rollin BE, VetCompass   +11 more
core   +3 more sources

Pupal and Adult Parameters as Potential Indicators of Cottonwood Leaf Beetle (Coleoptera: Chrysomelidae) Fecundity and Longevity [PDF]

, 2018
Cottonwood leaf beetle, Chrysomela scripta, pupae from a laboratory colony were weighed and monitored through adult emergence, oviposition, and mortality to determine if correlations existed between various pupal or adult parameters and fecundity or ...
Coyle, David R, Hart, Elwood R, McMillin, Joel D   +2 more
core   +3 more sources

Longevity and mortality of owned dogs in England [PDF]

, 2013
Improved understanding of longevity represents a significant welfare opportunity for the domestic dog, given its unparalleled morphological diversity.
Brodbelt, D C, Church, D B, McGreevy, P D, O'Neill, D G, Sydney, Thomson, P C   +5 more
core   +3 more sources

Utilization of defined microbial communities enables effective evaluation of meta-genomic assemblies

BMC Genomics, 2017
Background Metagenomics is the study of the microbial genomes isolated from communities found on our bodies or in our environment. By correctly determining the relation between human health and the human associated microbial communities, novel mechanisms
William W. Greenwald, Niels Klitgord, Victor Seguritan, Shibu Yooseph, J. Craig Venter, Chad Garner, Karen E. Nelson, Weizhong Li   +7 more
doaj   +1 more source

It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]

, 2016
The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
core   +2 more sources

Longevity and mortality in Kennel Club registered dog breeds in the UK in 2014 [PDF]

, 2018
Background The domestic dog is one of the most diverse mammalian species, exhibiting wide variations in morphology, behaviour and morbidity across breeds.
Evans, K M, Lewis, T W, Llewellyn-Zaidi, A M, O'Neill, D G, Wiles, B M   +4 more
core   +2 more sources

A set of common buccal CpGs that predict epigenetic age and associate with lifespan-regulating genes

iScience, 2022
Summary: Epigenetic aging clocks are computational models that use DNA methylation sites to predict age. Since cheek swabs are non-invasive and painless, collecting DNA from buccal tissue is highly desirable.
Adiv A. Johnson, Nicole S. Torosin, Maxim N. Shokhirev, Trinna L. Cuellar   +3 more
doaj   +1 more source

Changes in insulin, adiponectin and lipid concentrations with age are associated with frailty and reduced quality of life in dogs

Scientific Reports
Declining metabolic function with aging is a conserved phenotype across many species. While aging-associated changes in metabolic status have been investigated rigorously in humans, less is known about metabolic aging in dogs.
Brennen McKenzie, Matthew Peloquin, Jessica L. Graves, Frances Chen, Ashley Tovar, Tennery A. Carttar, Katya Tucker, Kenny Vo, Michelle Nelson, Kaitlyn M. Super, Jessica Austriaco, Sunny Y. Weber, Alexander Naka, Erin E. McCandless, Karen Greenwood, Dina Juarez-Salinas, Celine-Lea Halioua-Haubold, Ellen R. Ratcliff   +17 more
doaj   +1 more source