Genome Medicine, 2020 Background Modern medicine is rapidly moving towards a data-driven paradigm based on comprehensive multimodal health assessments. Integrated analysis of data from different modalities has the potential of uncovering novel biomarkers and disease ...
Ilan Shomorony +19 more
doaj +1 more source
Maximum Market Price of Longevity Risk under Solvency Regimes: The Case of Solvency II. [PDF]
, 2016 Longevity risk constitutes an important risk factor for life insurance companies, and it can be managed through longevity-linked securities. The market of longevity-linked securities is at present far from being complete and does not allow finding a ...
Helena Leino-Kilpi (3471101) +5 more
core +5 more sources
Longevity and mortality of cats attending primary care veterinary practices in England [PDF]
, 2014 Enhanced knowledge on longevity and mortality in cats should support improved breeding, husbandry, clinical care and disease prevention strategies. The VetCompass research database of primary care veterinary practice data offers an extensive resource of ...
Bessant C +11 more
core +3 more sources
Single and cross-generation natural hedging of longevity and financial risk [PDF]
, 2012 The paper provides natural hedging strategies among death benefits and annuities written on a single and on different generations. It obtains closed-form Delta and Gamma hedges, in the presence of both longevity and interest rate risk.
Luciano, Elisa +2 more
core +2 more sources
Longevity and mortality of owned dogs in England [PDF]
, 2013 Improved understanding of longevity represents a significant welfare opportunity for the domestic dog, given its unparalleled morphological diversity.
Brodbelt, D C +5 more
core +3 more sources
It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]
, 2016 The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
core +2 more sources
Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans [PDF]
, 2019 Target of rapamycin (TOR) signaling is an evolutionarily well-conserved pathway that regulates various physiologic processes, including aging and metabolism. One of the key downstream components of TOR signaling is ribosomal protein S6 kinase (S6K) whose
daeeun jeong +5 more
core +1 more source
A set of common buccal CpGs that predict epigenetic age and associate with lifespan-regulating genes
iScience, 2022 Summary: Epigenetic aging clocks are computational models that use DNA methylation sites to predict age. Since cheek swabs are non-invasive and painless, collecting DNA from buccal tissue is highly desirable.
Adiv A. Johnson +3 more
doaj +1 more source
Utilization of defined microbial communities enables effective evaluation of meta-genomic assemblies
BMC Genomics, 2017 Background Metagenomics is the study of the microbial genomes isolated from communities found on our bodies or in our environment. By correctly determining the relation between human health and the human associated microbial communities, novel mechanisms
William W. Greenwald +7 more
doaj +1 more source
Predicting Future Duration from Present Age: A Critical Assessment [PDF]
, 2000 Using a temporal version of the Copernican principle, Gott has proposed a statistical predictor of future longevity based on present age [J. R. Gott III, Nature 363, 315 (1993)] and applied the predictor to a variety of examples, including the longevity ...
Caves, Carlton M.
core +4 more sources