Results 41 to 50 of about 2,996,820 (336)

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Signal Detection and Monitoring Based on Longitudinal Healthcare Data

Pharmaceutics, 2012
Post-marketing detection and surveillance of potential safety hazards are crucial tasks in pharmacovigilance. To uncover such safety risks, a wide set of techniques has been developed for spontaneous reporting data and, more recently, for longitudinal ...
Iris Pigeot, Marc Suling
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

A novel protocol for a "Citizen Panel" for diverse Public and Participant Involvement in the review and development of the process to access data in the UK Longitudinal Linkage Collaboration Trusted Research Environment

International Journal of Population Data Science
Background Researchers can apply to UK Longitudinal Linkage Collaboration (UK LLC) to access Longitudinal Population Study (LPS) data linked to health, non-health administrative and geo-environmental data.
Lidis Garbovan, Betty O. Idemudia, Robin Flaig, Kirsteen Campbell, Katharine Evans, Andy Boyd, Sarah Cunningham-Burley, Emma L. Turner   +7 more
doaj   +1 more source

Influence of User Preferences on the Revealed Utility Factor of Plug-In Hybrid Electric Vehicles

World Electric Vehicle Journal, 2019
Plug-in hybrid electric vehicles (PHEVs) are an effective intermediate vehicle technology option in the long-term transition pathway towards light-duty vehicle electrification.
Seshadri Srinivasa Raghavan, Gil Tal
doaj   +1 more source

Anxiety among healthcare workers during the COVID-19 pandemic: a longitudinal study

Frontiers in Public Health, 2023
BackgroundDuring the COVID-19 pandemic, many healthcare workers faced extreme working conditions and were at higher risk of infection with the coronavirus.
Esmee Bosma, Verena Feenstra, Sandra H. van Oostrom, Lifelines Corona Research Initiative, H. Marike Boezen, Jochen O. Mierau, H. Lude Franke, Jackie Dekens, Patrick Deelen, Pauline Lanting, Judith M. Vonk, Ilja Nolte, Anil P.S. Ori, Annique Claringbould, Floranne Boulogne, Marjolein X.L. Dijkema, Henry H. Wiersma, Robert Warmerdam, Soesma A. Jankipersadsing, Irene van Blokland, Geertruida H. de Bock, Judith GM Rosmalen, Cisca Wijmenga   +22 more
doaj   +1 more source

A generalized linear mixed model for longitudinal binary data with a marginal logit link function [PDF]

, 2011
Longitudinal studies of a binary outcome are common in the health, social, and behavioral sciences. In general, a feature of random effects logistic regression models for longitudinal binary data is that the marginal functional form, when integrated over
Fitzmaurice, Garrett M., Ghosh, Souparno, Ibrahim, Joseph G., Lipsitz, Stuart, Mallick, Bani K., Parzen, Michael, Sinha, Debajyoti   +6 more
core   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer's Disease Data. [PDF]

, 2019
There is well-documented evidence of brain network differences between individuals with Alzheimer's disease (AD) and healthy controls (HC). To date, imaging studies investigating brain networks in these populations have typically been cross-sectional ...
Alzheimer’s Disease Neuroimaging Initiative, Galvin, James, Guo, Ying, Kundu, Suprateek, Lukemire, Joshua, Wang, Yikai   +5 more
core   +2 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source