Results 51 to 60 of about 3,225,781 (282)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
BarekengThis study investigates the application of a truncated spline nonparametric regression model for biresponse analysis of longitudinal data, focusing on modeling monthly stock prices specifically opening and closing prices of three private banks in ...
Reza Pahlepi +3 more
doaj +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Modelling longitudinal cognitive test data with ceiling effects and left skewness
Frontiers in Applied Mathematics and StatisticsCognitive tests such as the Mini Mental State Examination (MMSE) may result in data with discrete and skewed distributions that necessitate proper statistical models for valid inference.
Denitsa Grigorova +5 more
doaj +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Entrepreneurial Networking in China and Russia: Comparative Analysis and Implications for Western Executives [PDF]
, 2002 In this article, I compare personal networks of Chinese and Russian entrepreneurs in terms of network structure, relationships and resources accessed in networks.
Batjargal, Bat
core
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Genetics and Molecular Biology, 2008 Random regression models (RRM) were used to estimate covariance functions for 2,155 first-lactation milk yields of native Brazilian Caracu heifers. The models included contemporary group (defined as year-month of test and paddock) fixed effects, and ...
Lenira El Faro +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Crossing MGLS with the Middle Grades Research Agenda: A Guide for Researchers [PDF]
, 2018 For the past several years, leaders in middle grades education research have strengthened their call for more methodologically robust quantitative research to address important questions in the field.
Bishop, Penny A, Olofson, Mark W.
core +2 more sources