Results 51 to 60 of about 25,582,243 (263)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The Australian Longitudinal Study on Women's Health: 1989-95 cohort Core Data Release, Survey 1 data, 2013

, 2020
The Australian Longitudinal Study on Women's Health (ALSWH) is a longitudinal population-based survey, first funded in 1995, which examines the health of over 57,000 Australian women.
Mishra, Gita, Tooth, Leigh, Commonwealth Government Department of Health and Ageing, Lee, Christina, Dobson, Annette, Loxton, Deborah, Sibbritt, David, Tavener, Meredith, Brown, Wendy, Byles, Julie, Lucke, Jayne, Pachana, Nancy, McLaughlin, Deirdre   +12 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Australian Longitudinal Study on Women's Health: 1946-51 cohort Core Data Release, Survey 1 data, 1996

, 2020
The Australian Longitudinal Study on Women's Health (ALSWH) is a longitudinal population-based survey, first funded in 1995, which examines the health of over 57,000 Australian women.
Commonwealth Government Department of Health and Ageing, Manderson, Lenore, Byles, Julie, Schofield, Margot, Dobson, Annette J., Bryson, Lois, Williams, Gail   +6 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

BIRESPONSE SPLINE TRUNCATED NONPARAMETRIC REGRESSION MODELING FOR LONGITUDINAL DATA ON MONTHLY STOCK PRICES OF THREE PRIVATE BANKS IN INDONESIA

Barekeng
This study investigates the application of a truncated spline nonparametric regression model for biresponse analysis of longitudinal data, focusing on modeling monthly stock prices specifically opening and closing prices of three private banks in ...
Reza Pahlepi, Idhia Sriliana, Winalia Agwil, Cinta Rizki Oktarina   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Modelling longitudinal cognitive test data with ceiling effects and left skewness

Frontiers in Applied Mathematics and Statistics
Cognitive tests such as the Mini Mental State Examination (MMSE) may result in data with discrete and skewed distributions that necessitate proper statistical models for valid inference.
Denitsa Grigorova, Denitsa Grigorova, Dean Palejev, Dean Palejev, Ralitza Gueorguieva, for the Alzheimer's Disease Neuroimaging Initiative   +5 more
doaj   +1 more source

The Australian Longitudinal Study on Women's Health: 1921-26 cohort Core Data Release, Survey 6 data, 2011

, 2020
The Australian Longitudinal Study on Women's Health (ALSWH) is a longitudinal population-based survey, first funded in 1995, which examines the health of over 57,000 Australian women.
Mishra, Gita, Tooth, Leigh, Commonwealth Government Department of Health and Ageing, Lee, Christina, Dobson, Annette, Brown, Wendy, Byles, Julie, Lucke, Jayne, Loxton, Deborah, Sibbritt, David, Pachana, Nancy   +10 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source