Results 61 to 70 of about 25,582,243 (263)

Variance component estimates applying random regression models for test-day milk yield in Caracu heifers (Bos taurus Artiodactyla, Bovidae)

Genetics and Molecular Biology, 2008
Random regression models (RRM) were used to estimate covariance functions for 2,155 first-lactation milk yields of native Brazilian Caracu heifers. The models included contemporary group (defined as year-month of test and paddock) fixed effects, and ...
Lenira El Faro, Vera Lucia Cardoso, Lucia Galvão de Albuquerque   +2 more
doaj   +1 more source

The Australian Longitudinal Study on Women's Health: 1921-26 cohort Core Data Release, Survey 4 data, 2005

, 2020
The Australian Longitudinal Study on Women's Health (ALSWH) is a longitudinal population-based survey, first funded in 1995, which examines the health of over 57,000 Australian women.
Commonwealth Government Department of Health and Ageing, Lee, Christina, Dobson, Annette, Warner Smith, Penny, Byles, Julie, Young, Anne, Brown, Wendy J, Bryson, Lois   +7 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Australian Longitudinal Study on Women's Health: 1989-95 cohort Core Data Release, Survey 5 data, 2017

, 2020
The Australian Longitudinal Study on Women's Health (ALSWH) is a longitudinal population-based survey, first funded in 1995, which examines the health of over 57,000 Australian women.
Mishra, Gita, Tooth, Leigh, Byles, Julie, Loxton, Deborah, Australian Government Department of Health   +4 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Sex-differences in age-related grip strength decline: A 10-year longitudinal study of community-living middle-aged and older Japanese

Journal of Physical Fitness and Sports Medicine, 2016
The purpose of this study was to estimate sex differences in age-related grip strength decline and describe the course of decline in grip strength from age 40 to 89 years by a longitudinal epidemiological study.
Rumi Kozakai, Fujiko Ando, Heung Youl Kim, Atsumu Yuki, Rei Otsuka, Hiroshi Shimokata   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Integrated noninvasive diagnostics for prediction of survival in immunotherapy

Immuno-Oncology and Technology
Background: Integrating complementary diagnostic data sources promises enhanced robustness in the predictive performance of artificial intelligence (AI) models, a crucial requirement for future clinical validation/implementation.
M. Yeghaian, Z. Bodalal, T.M. Tareco Bucho, I. Kurilova, C.U. Blank, E.F. Smit, M.S. van der Heijden, T.D.L. Nguyen-Kim, D. van den Broek, R.G.H. Beets-Tan, S. Trebeschi   +10 more
doaj   +1 more source

The Australian Longitudinal Study on Women's Health: 1946-51 cohort Core Data Release, Survey 5 data, 2007

, 2020
The Australian Longitudinal Study on Women's Health (ALSWH) is a longitudinal population-based survey, first funded in 1995, which examines the health of over 57,000 Australian women.
Tooth, Leigh, Commonwealth Government Department of Health and Ageing, Lee, Christina, Dobson, Annette, Warner Smith, Penny, Brown, Wendy, Byles, Julie, Lucke, Jayne, Loxton, Deborah, Young, Anne, Bryson, Lois   +10 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source