Results 61 to 70 of about 3,225,781 (282)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Integrated noninvasive diagnostics for prediction of survival in immunotherapy

Immuno-Oncology and Technology
Background: Integrating complementary diagnostic data sources promises enhanced robustness in the predictive performance of artificial intelligence (AI) models, a crucial requirement for future clinical validation/implementation.
M. Yeghaian, Z. Bodalal, T.M. Tareco Bucho, I. Kurilova, C.U. Blank, E.F. Smit, M.S. van der Heijden, T.D.L. Nguyen-Kim, D. van den Broek, R.G.H. Beets-Tan, S. Trebeschi   +10 more
doaj   +1 more source

Sex-differences in age-related grip strength decline: A 10-year longitudinal study of community-living middle-aged and older Japanese

Journal of Physical Fitness and Sports Medicine, 2016
The purpose of this study was to estimate sex differences in age-related grip strength decline and describe the course of decline in grip strength from age 40 to 89 years by a longitudinal epidemiological study.
Rumi Kozakai, Fujiko Ando, Heung Youl Kim, Atsumu Yuki, Rei Otsuka, Hiroshi Shimokata   +5 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Model-Free Feature Screening Based on Data Aggregation for Ultra-High-Dimensional Longitudinal Data

Stats
Ultra-high dimensional longitudinal data feature screening procedures are widely studied, but most require model assumptions. The screening performance of these methods may not be excellent if we specify an incorrect model.
Junfeng Chen, Xiaoguang Yang, Jing Dai, Yunming Li   +3 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Parental concerns correspond to earliest age of autism diagnosis in increased likelihood infant cohort

Frontiers in Child and Adolescent Psychiatry
Autism spectrum disorder (ASD) encompasses a set of behavioural features with a diverse range of presentations, challenges, and trajectories. Previous research has demonstrated how behavioural and developmental markers can differentiate autistic from non-
Kal Clintberg, Lori-Ann R. Sacrey, Lonnie Zwaigenbaum, Jessica A. Brian, Peter Szatmari, Tracy Vaillancourt   +5 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

What the next generation of doctors want from a career in psychiatry: longitudinal survey of UK trainees and medical students

BJPsych Bulletin
Workforce planning aims to model and predict supply and demand in medical specialties. In Scotland it is undertaken jointly by the Scottish Government and the Royal College of Psychiatrists in Scotland to ensure workforce sustainability.
Nagore Penades, Brooke Marron, Darragh Hamilton   +2 more
doaj   +1 more source