Results 41 to 50 of about 3,225,781 (282)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

ADRUK Ingest Improvement Task and Finish Group: Smoothing the ingest of data

International Journal of Population Data Science
Objectives Analysts ingest data to TREs for research; extract, process and curate public sector data then made accessible to researchers in safe environments. Although differences surround each dataset, the processes can be made broadly replicable.
Jen Bishop, Linus Chirchir, Rachel Coey, Amy Dunlop, Hywel Evans, David Grzybowski, Alan Harbinson, Cristina Magder, Nichola McCullough, Richard McFerran, Jen Muir, Alex Ramage, Stella Telford, Richard Thomas, Tudor Vilcan   +14 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Using natural language processing to facilitate the harmonisation of mental health questionnaires: a validation study using real-world data

BMC Psychiatry
Background Pooling data from different sources will advance mental health research by providing larger sample sizes and allowing cross-study comparisons; however, the heterogeneity in how variables are measured across studies poses a challenge to this ...
Eoin McElroy, Thomas Wood, Raymond Bond, Maurice Mulvenna, Mark Shevlin, George B. Ploubidis, Mauricio Scopel Hoffmann, Bettina Moltrecht   +7 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Growth dynamics of Indian infants using latent trajectory models in pooled survey datasets

Frontiers in Public Health
BackgroundNational survey data show that age- and sex-standardized weight and length measurements decline early in Indian children. In population-level longitudinal data, early detection of growth trajectories is important for the implementation of ...
Aswathi Saji, Jeswin Baby, Jeswin Baby, Prem Antony, Srishti Sinha, Sulagna Bandyopadhyay, Joby K. Jose, Anura V. Kurpad, Tinku Thomas   +8 more
doaj   +1 more source

Multicollinearity and Linear Predictor Link Function Problems in Regression Modelling of Longitudinal Data

Mathematics, 2023
In the longitudinal data analysis we integrate flexible linear predictor link function and high-correlated predictor variables. Our approach uses B-splines for non-parametric part in the linear predictor component.
Mozhgan Taavoni, Mohammad Arashi, Samuel Manda   +2 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Characterization of Inclination Analysis for Predicting Onset of Heart Failure from Primary Care Electronic Medical Records

Sensors, 2023
The aim of this study is to characterize the performance of an inclination analysis for predicting the onset of heart failure (HF) from routinely collected clinical biomarkers extracted from primary care electronic medical records.
Federica Guida, Marta Lenatti, Karim Keshavjee, Alireza Khatami, Aziz Guergachi, Alessia Paglialonga   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source