Results 111 to 120 of about 44,936,151 (395)

The factors associated with entry to formal care for the elderly in Scotland: A longitudinal analysis

International Journal of Population Data Science, 2018
Background Losing independence is a concern for older people, and sadly a reality for many. In Scotland there is an ageing population and unlike the rest of the UK, a policy to provide free personal and nursing care for those in need of assistance; this ...
D. Helen Corby, Dawn Everington, John Starr, Ian J. Deary, Chris Dibben   +4 more
doaj   +1 more source

Durable B‐Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Ocrelizumab (OCR), a humanized anti‐CD20 monoclonal antibody, is highly efficient in relapsing–remitting multiple sclerosis (RR‐MS). We assessed early cellular B‐cell profiles in patients prior to OCR treatment, on OCR treatment, and after 15 months of therapy discontinuation.
Alexandra Garcia, Stephane Rodriguez, Emilie Dugast, Christine Lebrun‐Frenay, Eric Thouvenot, Jérôme de Sèze, Emmanuelle Le Page, Sandra Vukusic, Inès Doghri, Eric Berger, Olivier Casez, Pierre Labauge, Aurélie Ruet, Catarina Raposo, Fabienne Le Frère, Arnaud B. Nicot, Sandrine Wiertlewski, Pierre‐Antoine Gourraud, Laure Michel, Laureline Berthelot, David‐Axel Laplaud   +20 more
wiley   +1 more source

Alzheimer's Disease Prediction Using Longitudinal and Heterogeneous Magnetic Resonance Imaging

, 2018
Recent evidence has shown that structural magnetic resonance imaging (MRI) is an effective tool for Alzheimer's disease (AD) prediction and diagnosis. While traditional MRI-based diagnosis uses images acquired at a single time point, a longitudinal study
Dai, Xiaowu, Initiative, Alzheimer's Disease Neuroimaging   +1 more
core  

Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pure autonomic failure (PAF) presents with autonomic failure without other neurological features. A third develop central neurological features, fulfilling criteria for multiple system atrophy (MSA) and Lewy body diseases (LBD), including Parkinson's disease and Dementia with Lewy bodies.
S. Koay, E. Vichayanrat, F. Bremner, F. Valerio, R. Mackenzie, G. Chiaro, G. Ingle, P. McNamara, L. Watson, J. N. Panicker, M. P. Lunn, C. Mathias, V. Iodice   +12 more
wiley   +1 more source

Compensating for Missing Data from Longitudinal Studies Using WinBUGS [PDF]

Missing data is a common problem in survey based research. There are many packages that compensate for missing data but few can easily compensate for missing longitudinal data.
Adrian G. Barnett, Annette J. Dobson, Gita Mishra, Gretchen Carrigan   +3 more
core   +1 more source

Exploring if Longitudinal Changes on PET Imaging Can Serve as a Biomarker for Stiff Person Syndrome Spectrum Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify metabolic patterns in the brain and musculoskeletal system of stiff person syndrome spectrum disorders (SPSD) patients over time using PET imaging and evaluate the impact of immune therapy on metabolic activity as a surrogate for treatment response.
Munther M. Queisi, Samantha N. Roman, Mohammad S. Sadaghiani, Lilja B. Solnes, Scott D. Newsome   +4 more
wiley   +1 more source

The mediation roles of intermuscular fat and inflammation in muscle mitochondrial associations with cognition and mobility

Journal of Cachexia, Sarcopenia and Muscle
Background Mitochondrial dysfunction may contribute to brain and muscle health through inflammation or fat infiltration in the muscle, both of which are associated with cognitive function and mobility. We aimed to examine the association between skeletal
Qu Tian, Philip R. Lee, Qi Yang, Anne Z. Moore, Bennett A. Landman, Susan M. Resnick, Luigi Ferrucci   +6 more
doaj   +1 more source

The Office for National Statistics Longitudinal Study

International Journal of Population Data Science, 2019
Background and Rationale The ONS Longitudinal Study (‘the LS’) covers England and Wales and includes individual data from the 1971 – 2011 decennial censuses and linked information on births, deaths and cancer registrations.
Alison Sizer, Oliver Duke-Williams
doaj   +1 more source

Operationalising resilience in longitudinal studies: a systematic review of methodological approaches

Journal of Epidemiology and Community Health, 2016
Over the life course, we are invariably faced with some form of adversity. The process of positively adapting to adverse events is known as ‘resilience’.
T. Cosco, A. Kaushal, R. Hardy, M. Richards, D. Kuh, Mai Stafford   +5 more
semanticscholar   +1 more source

NOTCH2NLC Repeat Expansions in Parkinsonian Disorders: Clinical and Neuroimaging Characteristics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder caused by NOTCH2NLC GGC repeat expansions, with heterogeneous clinical manifestations, including parkinsonism. Recent studies have identified NOTCH2NLC repeat expansions in patients with Parkinson's disease (PD) and atypical parkinsonism (aPM), suggesting ...
Han‐Lin Chiang, Kang‐Yang Jih, Cheng‐Tsung Hsiao, Fu‐Pang Chang, Justus Chunyu Chen, Yi‐Chu Liao, Yih‐Ru Wu, Yi‐Chung Lee   +7 more
wiley   +1 more source