Results 101 to 110 of about 49,991,940 (357)
Searching for a mitochondrial root to the decline in muscle function with ageing
Journal of Cachexia, Sarcopenia and Muscle, 2018 Sarcopenia, the age‐related loss of muscle mass and strength, is linked to a range of adverse outcomes, such as impaired physical performance, cognitive function, and mortality. Preventing sarcopenia may reduce the burden of functional decline with aging
Marta Gonzalez‐Freire +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Clinical Psychology Review, 2017 BACKGROUND Three out of four first-episode psychosis (FEP) patients achieve clinical remission following treatment. Unfortunately, functional recovery lags behind symptomatic remission, and many individuals with FEP remain socially isolated with poor ...
Olga Santesteban-Echarri +6 more
semanticscholar +1 more source
Integrating area-based and national samples in birth cohort studies:the case of Life Study [PDF]
, 2017 The most recent UK birth cohort study, known as ‘Life Study’ was a longitudinal study planned to involve some 80,000 babies and comprised two components. The largest, the ‘Pregnancy Component’ was to consist of around 60,000 pregnant women who were to be
Sera, F +11 more
core +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
, 2018 The topics included in this issue range from the imputation of missing data in longitudinal surveys to demonstrating that their results make a difference in the public arena – both challenges to our research field the world over.
Joshi, Heather
core +1 more source
Predictors of mental health help-seeking among Polish people living in the United Kingdom
BMC Health Services Research, 2018 Background Migration has been shown to be associated with negative mental health outcomes. Moreover, migrants tend to underutilise mental health services.
Dawid Gondek, James B. Kirkbride
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
, 2017 copyright UK Data Service and data collection copyright owner.The Cohort and Longitudinal Studies Enhancement Resources (CLOSER) project aims to maximise the use, value and impact of longitudinal research. It brings together leading longitudinal studies,
Cohort and Longitudinal Studies Enhancement Resources
core
Social-biological transitions: how does the social become biological?
, 2013 The present discussion paper sets forward a model within the life course perspective of how the social becomes biological. The model is intended to provide a framework for thinking about such questions as how does social class get into the molecules ...
d'Errico, Angelo, +9 more
core +1 more source