Results 81 to 90 of about 49,991,940 (357)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Shift Work and Poor Mental Health: A Meta-Analysis of Longitudinal Studies.

American Journal of Public Health, 2019
Background. Shift work is characterized by employees working outside the standard hours of 7:00 am to 6:00 pm. Because shift work includes night work, the normal sleep-wake cycle (circadian rhythm) is disrupted, with potential consequences for shift ...
L. Torquati, G. Mielke, W. Brown, N. Burton, T. Kolbe-Alexander   +4 more
semanticscholar   +1 more source

Integrating public engagement to promote transparent data use in a new UK-wide birth cohort

International Journal of Population Data Science
Public engagement is an important mechanism for ensuring that the voices of the public are integrated into study design and data use. The commissioning of a new UK-wide birth cohort study by the UKRI Economic and Social Research Council (ESRC), the ...
Alyce Raybould, Karen Dennison, Orla McBride, Erica Wong, Lisa Calderwood, Pasco Fearon, Alissa Goodman   +6 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The UK Coronavirus Job Retention Scheme and smoking, alcohol consumption and vaping during the COVID-19 pandemic: evidence from eight longitudinal population surveys

BMC Medicine, 2022
Background Employment disruptions can impact smoking and alcohol consumption. During the COVID-19 pandemic, many countries implemented furlough schemes to prevent job loss.
Michael J. Green, Jane Maddock, Giorgio Di Gessa, Bożena Wielgoszewska, Sam Parsons, Gareth J. Griffith, Jazz Croft, Anna J. Stevenson, Charlotte F. Huggins, Charlotte Booth, Jacques Wels, Richard J. Silverwood, Praveetha Patalay, Alun D. Hughes, Nishi Chaturvedi, Laura D. Howe, Emla Fitzsimons, Srinivasa Vittal Katikireddi, George B. Ploubidis   +18 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Risk factors and protective factors associated with incident or increase of frailty among community-dwelling older adults: A systematic review of longitudinal studies

PLoS ONE, 2017
Introduction Frailty is one of the greatest challenges facing our aging population, as it can lead to adverse outcomes such as institutionalization, hospitalization, and mortality.
Zeyun Feng, M. Lugtenberg, C. Franse, Xinye Fang, Shanlian Hu, C. Jin, H. Raat   +6 more
semanticscholar   +1 more source

Zurich Longitudinal Study 'From School to Middle Adulthood'

, 2015
The Zurich Longitudinal Study 'From School to Middle Adulthood' (ZLSE) is a longitudinal study which, to date, encompasses ten surveys from various projects.
Hättich, Achim, Schellenberg, Claudia, Häfeli, Kurt, Schmaeh, Nicolas   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Getting better all the time? Selective attrition and compositional changes in longitudinal and life-course studies

, 2017
Longitudinal surveys are valuable tools for investigating health and social outcomes across the life course. In such studies, selective mortality leads to changes in the social composition of the sample, but little is known about how selective survey ...
Lennartsson, Carin, Fors, Stefan,, Fors, S,, Kelfve, Susanne,, Lennartsson, C,, Fors, Stefan, Lennartsson, Carin,, Kelfve, Susanne, Kelfve, S,   +8 more
core   +1 more source