Results 81 to 90 of about 14,877,772 (287)

Vulnerability as a heuristic concept for interdisciplinary research: assessing the thematic and methodological structure of empirical life course studies [PDF]

, 2014
Changes in human lives are studied in psychology, sociology, and adjacent fields as outcomes of developmental processes, institutional regulations and policies, culturally and normatively structured life courses, or empirical accounts.
Hanappi, Doris, Spini, Dario, Bernardi, Laura   +2 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Adolescents’ physical activity: cross-national comparisons of levels, distributions and disparities across 52 countries

International Journal of Behavioral Nutrition and Physical Activity, 2019
Background Despite global concerns regarding physical inactivity, limited cross-national evidence exists to compare adolescents’ physical activity participation.
David Bann, Shaun Scholes, Meg Fluharty, Nikki Shure   +3 more
doaj   +1 more source

Longitudinal studies are required [PDF]

Journal of the Royal Society of Medicine, 2015
Naseer, Ahmad, G Neil, Thomas, Paramjit, Gill, Colin, Chan, Francesco, Torella   +4 more
openaire   +2 more sources

Residential relocations and academic performance of Australian children: A longitudinal analysis [PDF]

, 2018
The family and residential environments are critical to children’s wellbeing and, hence, residential change can affect children’s developmental outcomes. In this research, we study the associations between residential relocations and academic performance
Vidal, Sergi, Janeen Baxter, Baxter, Janeen H., Sergi Vidal, Baxter, Janeen   +4 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

National Child Development Study: Age 42, Sweep 6 Geographical Identifiers, 1999-2000: Secure Access

, 2016
copyright UK Data Service and data collection copyright owner.The National Child Development Study (NCDS) is a continuing longitudinal study that seeks to follow the lives of all those living in Great Britain who were born in one particular ...
University of London, Institute of Education, Centre for Longitudinal Studies
core   +3 more sources

Lower Mitochondrial Energy Production of the Thigh Muscles in Patients With Low‐Normal Ankle‐Brachial Index

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundLower muscle mitochondrial energy production may contribute to impaired walking endurance in patients with peripheral arterial disease. A borderline ankle‐brachial index (ABI) of 0.91 to 1.10 is associated with poorer walking endurance compared
Majd AlGhatrif, Ariel Zane, Matt Oberdier, Marco Canepa, Stephanie Studenski, Eleanor Simonsick, Richard G. Spencer, Kenneth Fishbein, David Reiter, Edward G. Lakatta, Mary M. McDermott, Luigi Ferrucci   +11 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source