Results 71 to 80 of about 14,877,772 (287)

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Searching for a mitochondrial root to the decline in muscle function with ageing

Journal of Cachexia, Sarcopenia and Muscle, 2018
Sarcopenia, the age‐related loss of muscle mass and strength, is linked to a range of adverse outcomes, such as impaired physical performance, cognitive function, and mortality. Preventing sarcopenia may reduce the burden of functional decline with aging
Marta Gonzalez‐Freire, Fatemeh Adelnia, Ruin Moaddel, Luigi Ferrucci   +3 more
doaj   +1 more source

Volume 9, No 2

, 2018
Full issue of Longitudinal and Life Course Studies journal, Volume 9, No ...
Jeal, Sarah
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Selective drop-out in longitudinal studies and non-biased prediction of behaviour disorders [PDF]

, 2009
Background Participant drop-out occurs in all longitudinal studies, and if systematic, may lead to selection biases and erroneous conclusions being drawn from a study.
Samara, Muthanna, Waylen , Andrea E., Lamberts, Koen, Samara, M., Waylen, A., Steer, Colin, Ford, T., Waylen, Andrea, Ford, Tamsin, Steer, C., Wolke, D., Wolke, Dieter, Goodman, Robert, Goodman, Robert, MRCPsych, Lamberts, K., Goodman, R.   +15 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Gut Microbiota Affects Age-Related Plasma Metabolites

Microorganisms
Older age is a well-established risk factor for many chronic diseases, yet the biological mechanisms underlying this increased risk are not fully understood.
Jayanta K. Das, Chee W. Chia, Qu Tian, Angelina Angelova, Luigi Ferrucci, Toshiko Tanaka   +5 more
doaj   +1 more source

Predictors of mental health help-seeking among Polish people living in the United Kingdom

BMC Health Services Research, 2018
Background Migration has been shown to be associated with negative mental health outcomes. Moreover, migrants tend to underutilise mental health services.
Dawid Gondek, James B. Kirkbride
doaj   +1 more source