Results 71 to 80 of about 14,354,496 (289)
International Journal of Population Data ScienceObjectives The prevalence of mental disorders is high and increasing among children and young people. Investigating the relationship between self-reported poor mental health and mental health service utilisation can provide evidence on the benefits of ...
Gergo Baranyi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
From imputation to impact [PDF]
, 2018 The topics included in this issue range from the imputation of missing data in longitudinal surveys to demonstrating that their results make a difference in the public arena – both challenges to our research field the world over.
Joshi, Heather
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Harmonised Socio-Economic Measures in Four Longitudinal Cohort Studies: 1970 British Cohort Study
, 2018 copyright UK Data Service and data collection copyright owner.The Cohort and Longitudinal Studies Enhancement Resources (CLOSER) project aims to maximise the use, value and impact of longitudinal research. It brings together leading longitudinal studies,
Cohort and Longitudinal Studies Enhancement Resources
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Harmonised Socio-Economic Measures in Four Longitudinal Cohort Studies: Millennium Cohort Study
, 2018 copyright UK Data Service and data collection copyright owner.The Cohort and Longitudinal Studies Enhancement Resources (CLOSER) project aims to maximise the use, value and impact of longitudinal research. It brings together leading longitudinal studies,
Cohort and Longitudinal Studies Enhancement Resources
core +1 more source
Journal of the International AIDS Society, 2014 Introduction Hope is an essential dimension of successful coping in the context of illnesses such as HIV/AIDS, because positive expectations for the future alleviate emotional distress, enhance quality of life and have been linked to the capacity for ...
Caroline Masquillier +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Searching for a mitochondrial root to the decline in muscle function with ageing
Journal of Cachexia, Sarcopenia and Muscle, 2018 Sarcopenia, the age‐related loss of muscle mass and strength, is linked to a range of adverse outcomes, such as impaired physical performance, cognitive function, and mortality. Preventing sarcopenia may reduce the burden of functional decline with aging
Marta Gonzalez‐Freire +3 more
doaj +1 more source