Results 71 to 80 of about 1,192,915 (258)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The mediation roles of intermuscular fat and inflammation in muscle mitochondrial associations with cognition and mobility

Journal of Cachexia, Sarcopenia and Muscle
Background Mitochondrial dysfunction may contribute to brain and muscle health through inflammation or fat infiltration in the muscle, both of which are associated with cognitive function and mobility. We aimed to examine the association between skeletal
Qu Tian, Philip R. Lee, Qi Yang, Anne Z. Moore, Bennett A. Landman, Susan M. Resnick, Luigi Ferrucci   +6 more
doaj   +1 more source

The Office for National Statistics Longitudinal Study

International Journal of Population Data Science, 2019
Background and Rationale The ONS Longitudinal Study (‘the LS’) covers England and Wales and includes individual data from the 1971 – 2011 decennial censuses and linked information on births, deaths and cancer registrations.
Alison Sizer, Oliver Duke-Williams
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade

Nature Communications
Impaired muscle mitochondrial oxidative capacity is associated with future cognitive impairment, and higher levels of PET and blood biomarkers of Alzheimer’s disease and neurodegeneration.
Qu Tian, Erin E. Greig, Christos Davatzikos, Bennett A. Landman, Susan M. Resnick, Luigi Ferrucci   +5 more
doaj   +1 more source

Examining the quality and population representativeness of linked survey and administrative data: guidance and illustration using linked 1958 National Child Development Study and Hospital Episode Statistics data

International Journal of Population Data Science
Introduction Recent years have seen an increase in linkages between survey and administrative data. It is important to evaluate the quality of such data linkages to discern the likely reliability of ensuing research.
Richard Silverwood, Nasir Rajah, Lisa Calderwood, Bianca De Stavola, Katie Harron, George Ploubidis   +5 more
doaj   +1 more source

Waiting to inhale: factors associated with healthcare workers’ fears of occupationally-acquired tuberculosis (TB)

BMC Infectious Diseases, 2019
Background Fear of TB infection is rooted in historical and social memories of the disease, marked by stigma, segregation and exclusion. Healthcare workers (HCWs) face these same fears today, and even seek to hide their TB status when infected.
Michelle Engelbrecht, Asta Rau, Gladys Kigozi, André Janse van Rensburg, Edwin Wouters, Nina Sommerland, Caroline Masquillier, Kerry Uebel   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Patterns of physical activity in hunter-gatherer children compared with US and UK children

Scientific Reports
Contemporary hunter-gatherers are highly active, but little is known about physical activity levels in hunter-gatherer children. We analysed 150 days of accelerometer data from 51 BaYaka hunter-gatherer children (aged 3–18) in the Republic of Congo ...
Luke Kretschmer, Mark Dyble, Nikhil Chaudhary, David Bann, Gul Deniz Salali   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source