Results 61 to 70 of about 73,960 (240)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Measurement loop, automatic tuning and product quality tracking

MATEC Web of Conferences, 2018
Starting from the PDCA cycle (Plan - Do - Check - Act), imposed by the ISO 9000 quality standards, a loop is proposed to automatically adjust the work equipment to the statistical distribution of the quality feature of the last N products randomly ...
Man Dietrich Marcela, Popa Marcel Sabin
doaj   +1 more source

Semiclassical quantization of the mixed-flux AdS3 giant magnon

Journal of High Energy Physics, 2020
We obtain explicit formulas for the eight bosonic and eight fermionic fluctuations around the mixed-flux generalization of the Hofman-Maldacena giant magnon on AdS3 ×S3 ×T4 and AdS3 ×S3 ×S3 ×S1.
Adam Varga
doaj   +1 more source

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

Loop-Reduction LLL Algorithm and Architecture for Lattice-Reduction-Aided MIMO Detection

Journal of Electrical and Computer Engineering, 2012
We propose a loop-reduction LLL (LR-LLL) algorithm for lattice-reduction-aided (LRA) multi-input multioutput (MIMO) detection. The LLL algorithm is an iterative algorithm that contains many check and process operations; however, the traditional LLL ...
Chun-Fu Liao, Li-Wei Chai, Yuan-Hao Huang   +2 more
doaj   +1 more source

Structural and functional characterization of chitinase from carnivorous plant Drosera adelae

FEBS Open Bio, EarlyView.
A class I chitinase from the carnivorous plant Drosera adelae was expressed and purified using a yeast system, revealing high enzymatic activity. Structural analyses of the catalytic and chitin‐binding domains identified key tyrosine residues involved in substrate binding, offering insights into the enzyme's adaptation for insect digestion.
Kazunari Yoneda, Yuki Naruse, Yusaku Suizu, Tomohiro Araki, Yoshikazu Hoshi, Haruhiko Sakuraba, Junji Hayashi, Toshihisa Ohshima   +7 more
wiley   +1 more source

Hybrid of check matrix construction algorithm based on iteration coding algorithm

Dianzi Jishu Yingyong, 2018
In order to ensure the reliability, stability and high transmission rate of fifth-generation mobile communication technology(5G), this paper proposes a hybrid check matrix construction algorithm based on iterative coding algorithm with linear coding ...
Meng Jiahui, Zhao Danfeng, Zhang Liang
doaj   +1 more source

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

FEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu, Yumi Iwashita, Keisuke Tachibana, Itsuki Nishino, Yuki Niwa, Atsuko Uyeda, Kazuki Matsuo, Masahiro Nagahama, Masuo Kondoh   +8 more
wiley   +1 more source

Hadronic corrections to μ-e scattering at NNLO with space-like data

Journal of High Energy Physics, 2019
The Standard Model prediction for μ-e scattering at Next-to-Next-to-Leading Order (NNLO) contains non-perturbative QCD contributions given by diagrams with a hadronic vacuum polarization insertion in the photon propagator.
Matteo Fael
doaj   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source