Results 71 to 80 of about 830,140 (297)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Boundaries of amplituhedra and NMHV symbol alphabets at two loops

Journal of High Energy Physics, 2018
In this sequel to [3] we classify the boundaries of amplituhedra relevant for determining the branch points of general two-loop amplitudes in planar N=4 $$ \mathcal{N}=4 $$ super-Yang-Mills theory.
I. Prlina, M. Spradlin, J. Stankowicz, S. Stanojevic   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Überblick Bundestag Jugend-Check zum Entwurf eines Gesetzes zur Verbesserung der Rückführung (Rückführungsverbesserungsgesetz) (Kabinettsbefassung: 25.10.2023) [PDF]

, 2023
Der „Überblick Bundestag“ wird bei Jugend-Checks erstellt, bei welchen der Gesetzentwurf in der Kabinettsfassung vorliegt. Das bedeutet, dass dieser Gesetzentwurf in der vorliegenden Fassung im Bundestag diskutiert werden wird.
Kompetenzzentrum Jugend-Check
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Non-planar one-loop Parke-Taylor factors in the CHY approach for quadratic propagators

Journal of High Energy Physics, 2018
In this work we have studied the Kleiss-Kuijf relations for the recently introduced Parke-Taylor factors at one-loop in the CHY approach, that reproduce quadratic Feynman propagators.
Naser Ahmadiniaz, Humberto Gomez, Cristhiam Lopez-Arcos   +2 more
doaj   +1 more source

One-loop algebras and fixed flow trajectories in adjoint multi-scalar gauge theory

Journal of High Energy Physics, 2023
We study the one loop renormalisation of 4d SU(N) Yang-Mills theory with M adjoint representation scalar multiplets related by O(M) symmetry. General M are of field theoretic interest, and the 4d one loop beta function of the gauge coupling g 2 vanishes ...
Nadia Flodgren, Bo Sundborg
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Überblick Bundestag Jugend-Check zum Entwurf eines Zweiten Gesetzes zur Änderung des Jugendschutzgesetzes (Kabinettsfassung:14.10.2020) [PDF]

, 2020
Der „Überblick Bundestag“ wird bei Jugend-Checks erstellt, bei welchen der Gesetzentwurf in der Kabinettsfassung vorliegt. Das bedeutet, dass dieser Gesetzentwurf in der vorliegenden Fassung im Bundestag diskutiert werden wird.
Kompetenzzentrum Jugend-Check
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Jugend-Check zum Entwurf eines Haushaltsfinanzierungsgesetzes (Stand 16.08.2023) [PDF]

, 2023
Ziel des Gesetzes ist es, die im Bundeshaushalt 2024 und im Finanzplan bis 2027 festgelegten Änderungen umzusetzen, die zu einer Entlastung des Bundeshaushaltes und der Rückkehr zur finanziellen Normalität beitragen sollen. Diese Maßnahmen umfassen unter
Kompetenzzentrum Jugend-Check
core