Results 41 to 50 of about 939,936 (265)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa +7 more
wiley +1 more source
3D genomic organization in cancers
Quantitative Biology, 2023 Background The hierarchical three‐dimensional (3D) architectures of chromatin play an important role in fundamental biological processes, such as cell differentiation, cellular senescence, and transcriptional regulation.
Junting Wang +4 more
doaj +1 more source
Physics Letters B, 1982 Abstract The applicability of the collective coordinate method (saddle-point approximation) for large- N planar models is discussed. Some unstated assumptions are clarified. Statements that Wilson loops form a complete set of gauge invariant operators are also examined and a set of generalized algebraic Mandelstam relations among Wilson loops is ...
openaire +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Distribution and Research of Loop Speed Codes under IATP Fallback Mode
机车电传动, 2014 Aim to the present condition that signal system for urban rail transits project mostly was based on moving block train trafficcontrol system (CBTC) and appropriate fallback mode was taken into consideration for the CBTC systems in most cities ...
YANGHai-peng, SONGYan
doaj
HMGB1 coordinates SASP‐related chromatin folding and RNA homeostasis on the path to senescence
Molecular Systems Biology, 2021 Spatial organization and gene expression of mammalian chromosomes are maintained and regulated in conjunction with cell cycle progression. This is perturbed once cells enter senescence and the highly abundant HMGB1 protein is depleted from nuclei to act ...
Konstantinos Sofiadis +16 more
doaj +1 more source
Journal of Information Technology, 2020 The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.
openaire +2 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source