Results 101 to 110 of about 23,058 (301)

Influence of Gut Microbiota on Response to Immune Check Point Inhibitors in MASLD Patients With HCC: Unraveling the Connection

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Immune checkpoint inhibitors (ICIs) have emerged as a promising treatment for various cancers, including advanced hepatocellular carcinoma (HCC). However, a significant proportion of patients with HCC, particularly those with metabolic dysfunction‐associated liver disease (MASLD), exhibit resistance to ICI therapy.
Mazen Elsheikh, Mohamad Ali Ibrahim, Sherry Fares, Megha Bhongade, Karim Adhem, Ximena I. Ramirez‐Morales, Ahmed O. Kaseb, Joseph Petrosino, Manal M. Hassan, Prasun K. Jalal   +9 more
wiley   +1 more source

Evaluation of the Effect of Loperamide on the Cardiac Repolarization Interval Using Exposure–Response Analysis

Clinical and Translational Science
This analysis assessed the relationship between the plasma concentrations of loperamide and its N‐desmethyl loperamide meta‐ bolite (M1) and the potential QT interval prolongation at therapeutic and supratherapeutic doses.
Belén Valenzuela, Per Olsson Gisleskog, Iolanda Cirillo, Erwin Coenen, Jay Ariyawansa, Saberi Rana Ali, Samiha Takhtoukh, Juan José Pérez‐Ruixo, Oliver Ackaert   +8 more
doaj   +1 more source

Pellagra From Tryptophan Depletion in Carcinoid Syndrome due to a Pulmonary Atypical Carcinoid Neuroendocrine Tumor

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Pellagra may complicate functioning pulmonary atypical carcinoid and present as a subtle acral dermatosis rather than the classical photo‐distributed rash. In neuroendocrine tumor patients with chronic diarrhea and new skin changes, clinicians should suspect niacin deficiency and consider empiric nicotinamide, even when niacin assays are ...
Ahmar Iftikhar Talib, Cora Marks, Sheikh Saleem   +2 more
wiley   +1 more source

Antispasmodic activity of apigenin and luteolin, two components of Dracocephalum kotschyi extract, on rat ileum contractions [PDF]

, 2018
Introduction: Aerial parts of Dracocephalum kotschyi have been used as antispasmodic agents in Iranian traditional medicine. Recent pharmacological studies confirmed antispasmodic activity of D. kotschyi extract.
Asghari, Gholamreza., Ghanadian, Mostafa., Sadraei, Hassan., Sekhavati, Nastaran.   +3 more
core   +2 more sources

Loperamide [PDF]

Reactions Weekly, 2020
  +6 more sources

Noninvasive Ph-telemetric Measurement of Gastrointestinal Function [PDF]

, 1991
The purpose of this study was to gain experience with and validate the Heidelberg pH-telemetric methodology in order to determine if the pH-telemetric methodology would be a useful noninvasive measure of gastrointestinal transit time for future ground ...
Tietze, Karen J.
core   +1 more source

Measuring blood–brain barrier dysfunction: a critical appraisal of fluid biomarkers, in vitro models, in vivo imaging, and post‐mortem approaches

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract The blood–brain barrier (BBB) maintains central nervous system homeostasis by regulating molecular exchange between blood and brain. BBB dysfunction is associated with aging and neurological disorders such as Alzheimer's disease, stroke, and multiple sclerosis.
Shakira A. van der Panne, Helena Durrant, Jannis F. Heuer, Ivana Kancheva, Arno Stellingwerf, Lieuwe T. K. M. Verkaar, Damon Verstappen, Pascalle Mossel, Walter H. Backes, Erik N. T. P. Bakker, Jurgen A. H. R. Claassen, Marcel M. Verbeek, Louise van der Weerd, Matthias J. P. van Osch, Helga E. de Vries   +14 more
wiley   +1 more source

Final Efficacy and Safety Results of Pyrotinib Combined With Trastuzumab and Chemotherapy in Pre‐Treated Human Epidermal Growth Factor Receptor 2‐Positive Metastatic Breast Cancer

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Purpose Findings from our previous study showed that the combination of pyrotinib, trastuzumab, and chemotherapy represents a viable treatment strategy with an acceptable safety profile for heavily pre‐treated human epidermal growth factor receptor 2 (HER2)‐positive metastatic breast cancer (MBC).
Xiaofeng Xie, Daijia Huang, Jiayi Huang, Xuelian Chen, Xue Bai, Wenyu Zheng, Liping Chen, Xiaofeng Lan, Lin Song, Rongmei Lei, Caiwen Du   +10 more
wiley   +1 more source

Results from a Phase 1 Study of Sodium Selenite in Combination with Palliative Radiation Therapy in Patients with Metastatic Cancer. [PDF]

, 2019
In preclinical studies, selenite had single agent activity and radiosensitized tumors in vivo. Here we report results from a Phase 1 trial in 15 patients with metastatic cancer treated with selenite (5.5 to 49.5 mg) orally as a single dose 2 hours before
Buyyounouski, Mark K, Grimes, Kevin, Jayachandran, Priya, Keeling, Christine A, Knox, Susan J, Sandhu, Navjot, Savic, Rada, Shura, Lei, Stamps-DeAnda, Stacy Leanne, Stevens, Kathryn J   +9 more
core  

Quantification of Dynamic 11C-Phenytoin PET Studies [PDF]

, 2015
The overexpression of P-glycoprotein (Pgp) is thought to be an important mechanism of pharmacoresistance in epilepsy. Recently, 11C-phenytoin has been evaluated preclinically as a tracer for Pgp.
Bakker, Esther D.M., Boellaard, Ronald, Froklage, Femke E., Lammertsma, Adriaan, Mansor, Mohd Syahir, Schwarte, Lothar A., Verbeek, Joost, Voskuyl, Rob A., Windhorst, Albert D., Yaqub, Maqsood   +9 more
core   +1 more source