Results 241 to 250 of about 23,058 (301)

Broccoli-Derived Exosome-like Nanoparticles Alleviate Loperamide-Induced Constipation, in Correlation with Regulation on Gut Microbiota and Tryptophan Metabolism.

Journal of Agricultural and Food Chemistry, 2023
Constipation, a common gastrointestinal dysfunction, damages patients' life quality and predisposes them to other serious diseases. Current strategies against constipation often cause drug dependency and side effects.
Tianchi Duan, Xiaoyuan Wang, Xinyue Dong, Chennan Wang, Lu Wang, Xingbin Yang, Ting Li   +6 more
semanticscholar   +1 more source

Gut indigenous Ruminococcus gnavus alleviates constipation and stress-related behaviors in mice with loperamide-induced constipation.

Food & Function, 2023
Refractory constipation is the most severe form of constipation, and its etiology remains unknown. The symptoms of constipation occur repeatedly, which brings great pain to the patient's body and psychology. Accumulating studies suggest that constipation
Rong Li, Sheng Xu, Bei Li, Bo Zhang, Wei-Hua Chen, Die Dai, Zhi Liu   +6 more
semanticscholar   +1 more source

Loperamide, a peripheral Mu-Opioid receptor agonist, attenuates chemotherapy-induced neuropathic pain in rats.

International Immunopharmacology, 2023
Opioids are employed in the management of chemotherapy-induced neuropathic pain (CINP) when other pain management approaches have failed and proven ineffective.
Anagha Gadepalli, Obulapathi Ummadisetty, Akhilesh, Deepak Chouhan, Anmol, Vinod Tiwari   +5 more
semanticscholar   +1 more source

Modulation of gut microbiota ecosystem by a glucan-rich snail mucin heteropolysaccharide attenuates loperamide-induced constipation.

International Journal of Biological Macromolecules, 2023
The present study aimed to investigate the effect of oral administration of snail-derived mucin extract (SM) on ameliorating constipation symptoms of loperamide-induced constipated rats (n = 6).
Hoon Kim, E. Jeong, C. Park, Jeong-seok Lee, Woojun Kim, K. Yu, H. Suh, Yejin Ahn, S. Moon   +8 more
semanticscholar   +1 more source

Loperamide induces protective autophagy and apoptosis through the ROS/JNK signaling pathway in bladder cancer.

Biochemical Pharmacology, 2023
Bladder cancer is one of the most common carcinomas in the human urinary system worldwide. Loperamide, known as an antidiarrheal drug, exerts anti-tumor activities against various cancers. However, the effect of loperamide on bladder cancer cells remains
Jianjian Wu, Qiang Guo, Juntao Li, Hao Yuan, Chutian Xiao, Jianguang Qiu, Qiong Wu, Dejuan Wang   +7 more
semanticscholar   +1 more source

The rhizomes of Atractylodes macrocephala relieve loperamide-induced constipation in rats by regulation of tryptophan metabolism.

Journal of Ethnopharmacology, 2023
ETHNOPHARMACOLOGICAL RELEVANCE Constipation is one of the most prevalent gastrointestinal tract diseases that seriously affects health-related quality of human life and requires effective treatments without side effect.
Ling-Ling Qin, Meng Yu, Peng Yang, Zhongmei Zou   +3 more
semanticscholar   +1 more source

Croton tiglium L. seeds ameliorate loperamide-induced constipation via regulating gastrointestinal hormones and gut microbiota before and after processing.

Journal of Ethnopharmacology, 2023
ETHNOPHARMACOLOGICAL RELEVANCE Crotonis Fructus (CF), the seeds of Croton tiglium L., have been commonly used in the treatment of constipation for more than two thousand years in traditional Chinese medicine (TCM).
Ze-Fei Jia, Jia-Li Wang, Wen Pan, Jing Hu   +3 more
semanticscholar   +1 more source