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Results 91 to 100 of about 31,031 (195)

Co‐ and Multi‐Pathologies in Parkinson's Disease: An International Parkinson and Movement Disorder Society Scientific Issues Committee Review

Movement Disorders, EarlyView.
Abstract Parkinson's disease (PD) has been historically defined as a disease of striatal dopamine deficiency secondary to degeneration of dopaminergic neurons in the substantia nigra pars compacta, related to the presence of Lewy bodies and Lewy neurites.
Michele Matarazzo +10 more
wiley +1 more source

Frequency of ZFHX3‐Mediated Spinocerebellar Ataxia 4 in a US Undiagnosed Ataxia Cohort

Movement Disorders, EarlyView.
Abstract Background Spinocerebellar ataxia 4 (SCA4) is a late‐onset dominant ataxia with neuropathy caused by exonic GGC repeat expansion in the ZFHX3 gene thought to originate from a Swedish founder event. The GC‐rich expansion is highly thermodynamically stable, posing challenges for standard clinical genetic testing methods.
Annie Chen +320 more
wiley +1 more source

At‐Home Versus in‐Clinic Vital Capacity Measurement: Insights From the HEALEY ALS Platform Trial

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Respiratory weakness, typically monitored as vital capacity (VC), is a central feature of amyotrophic lateral sclerosis (ALS). VC is increasingly measured remotely in participants' homes, although in‐clinic assessment remains the standard.
Eric A. Macklin +269 more
wiley +1 more source

Malnutrition prevalence at hospital admission and discharge based on the two‐step Global Leadership Initiative on Malnutrition: A prospective observational study in Malawian adult patients

Nutrition in Clinical Practice, EarlyView.
Abstract Objective To assess the prevalence of malnutrition at hospital admission and discharge and examine factors associated with malnutrition at discharge among adult patients. Study Design A prospective observational study was conducted at two public referral hospitals in Malawi, targeting adult patients aged 18–65 years (n = 418).
Getrude Mphwanthe +7 more
wiley +1 more source

Shifting the paradigm: An Indigenous knowledge‐based stewardship plan to replenish boreal caribou in Athabasca Chipewyan and Mikisew Cree First Nations' homelands

People and Nature, EarlyView.
Abstract Indigenous Peoples in northern Alberta, including Dené and Cree of the Athabasca Chipewyan and Mikisew Cree First Nations (ACFN and MCFN), have been using Indigenous laws and stewardship principles to care for their homelands for thousands of years. Since ACFN and MCFN signed Treaty 8 with Canada in 1899, Alberta's land management policies and
Lori Cyprien +6 more
wiley +1 more source

Stakeholder and rightsholder engagement in environmental research: Lessons from Canadian scholars engaging diverse groups

People and Nature, EarlyView.
Abstract To promote inclusivity, relevance and actionability of environmental research, scholars are engaging with rightsholders and stakeholders (Indigenous groups, governments and individuals) to co‐produce research. These transdisciplinary approaches represent diverse forms of ‘engaged’ research (e.g.
Jennifer M. Holzer +18 more
wiley +1 more source

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink +5 more
wiley +1 more source

Riparian Failure: Damming and Flow Stabilization Exclude Cottonwood Colonization Along a Dryland River

River Research and Applications, EarlyView.
ABSTRACT The Marias River flows from Glacier National Park through northcentral Montana, and into the Missouri River. Annual flows gradually declined from 1902 to 2024 (~3.2%/decade) and the 1952 Tiber Dam and Lake Elwell reservoir were operated to attenuate peak flows and stabilize downstream flows year‐round.
Stewart B. Rood, Lori A. Goater
wiley +1 more source

Enhancing General and Academic L2 Writing Complexity Through Dialogue Journal Writing: The Role of Learners' Motivational Beliefs

TESOL Quarterly, EarlyView.
Abstract Writing is crucial in tertiary education, yet enhancing the complexity of academic writing presents significant challenges for second language (L2) learners. This study explores the potential of dialogue journal writing (DJW), an interactive and low‐stress classroom activity, to enhance writing complexity among novice L2 writers.
Barry Lee Reynolds, Xiaoke Bai, Brian V. Rusk +2 more
wiley +1 more source

Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models

Environmental Toxicology, EarlyView.
ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa +9 more
wiley +1 more source

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