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Lorazepam kinetics in the elderly

Clinical Pharmacology & Therapeutics, 1979
Lorazepam is a 3‐hydroxy‐1,4‐benzodiazepine derivative biotransformed by glucuronide conjugation, followed by urinary excretion of the glucuronide metabolite. The kinetic properties of single 1.5‐ to 3.0‐mg doses of intravenous lorazepam were assessed in 15 healthy elderly subjects, 60 to 84 yr of age, and in 15 healthy young subjects, 19 to 38 yr of ...
Marcia Divoll Allen   +4 more
openaire   +3 more sources

Lorazepam premedication for labour

BJOG: An International Journal of Obstetrics & Gynaecology, 1982
Summary. Fifty primigravidae were given either lorazepam (2 mg) or identical dummy tablets in early labour, in a randomized double‐blind fashion. Analgesia (standardized at pethidine 100 mg) was given as required, and pain relief was assessed by visual analogue scales.
M. P. O'neill   +3 more
openaire   +3 more sources

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