Results 31 to 40 of about 25,193 (261)

Lorazepam use during clinical trials of adults with bipolar mania episodes

Contemporary Clinical Trials Communications, 2023
Background: Lorazepam has commonly been prescribed to reduce agitation during bipolar 1 mania trials. Its use has varied considerably by trial methodology and in clinical practice.
Daniel J. Safer
doaj   +1 more source

ZnO/1-hexyl-3-methylimidazolium chloride paste electrode, highly sensitive lorazepam sensor

Journal of Electrochemical Science and Engineering, 2023
The measurement of pharmaceutical compounds in biological fluids is considered an effective way to evaluate their effectiveness. On the other hand, lorazepam is a drug with good efficiency in treatment and some side effects, which measurement is very ...
Seddigheh Chenarani, Mahmoud Ebrahimi, Vahid Arabali , Safar Ali Beyramabadi   +3 more
doaj   +1 more source

Comparison of lorazepam alone vs lorazepam, morphine, and perphenazine for cardiac premedication [PDF]

Canadian Journal of Anaesthesia, 1997
To compare the effects of two premedication regimens on cardiorespiratory variables, sedation, and anxiety in patients scheduled for coronary artery bypass graft (CABG) surgery.This was a prospective randomized, double-blind clinical trial. Sixty-eight patients were monitored for 1.5 hr before and 2.0 hr after premedication with lorazepam (0.03 mg.kg-1
Saccamanno, Pamela, M., Kavanagh, Brian, P., Cheng, Davy C.H., Katz, Joel, Sandler, Alan, N.   +4 more
openaire   +3 more sources

Differentiating anxiety from fear: an experimental–pharmacological approach

Personality Neuroscience, 2020
Gray’s theory of personality postulates that fear and anxiety are distinct emotional systems with only the latter being sensitive to anxiolytic drugs.
Julia V. Lippold, Ulrich Ettinger, René Hurlemann, Philip J. Corr, Martin Reuter, Adam M. Perkins   +5 more
doaj   +1 more source

Structural Characterization of Co-Crystals of Chlordiazepoxide with p-Aminobenzoic Acid and Lorazepam with Nicotinamide by DSC, X-ray Diffraction, FTIR and Raman Spectroscopy

Pharmaceutics, 2020
The low water solubility of benzodiazepines seriously affects their bioavailability and, in consequence, their biological activity. Since co-crystallization has been found to be a promising way to modify undesirable properties in active pharmaceutical ...
Patrycja Garbacz, Dominik Paukszta, Artur Sikorski, Marek Wesolowski   +3 more
doaj   +1 more source

Refractory Status Epilepticus and Therapeutic Uncertainties: a Comprehensive Review on Targeting Neuroinflammation and Rationale for Developing a Platform Trial

Advanced Science, EarlyView.
Refractory status epilepticus (RSE) is a life‐threatening neurological emergency with high rates of death and long‐term disability, but treatments for it are often based on limited evidence. RSE is now understood to involve neuroinflammation, which has led to the exploration of anti‐inflammatory and immunomodulatory agents like Tocilizumab. Traditional
Shanika Samarasekera, Suneesh Thilak, Asha Patel, Prashant Nasa, Zubair Ahmed, Lorraine Jacques, William J. Scotton, Cyril Chacko, Randeep Mullhi, Ruoling Chen, Vikram Patil, Suresh Renukappa, Tonny Veenith   +12 more
wiley   +1 more source

A Retrospective Analysis on Clinical Practice-Based Approaches Using Zolpidem and Lorazepam in Disorders of Consciousness

Brain Sciences, 2021
This is a retrospective study to investigate the results of using zolpidem and lorazepam in persons with disorders of consciousness (DoC) and to provide practical information for clinical application and further studies. The cohort included 146 patients (
Bei Zhang, Katherine O’Brien, William Won, Sheng Li   +3 more
doaj   +1 more source

Pharmacokinetic profiles of sertraline in pregnancy as a predictor of postpartum depressive symptoms

British Journal of Clinical Pharmacology, EarlyView.
Aim To characterize pharmacokinetic changes of sertraline and its metabolite during pregnancy and postpartum, and their relationship to maternal postpartum depressive symptoms. Methods This was a prospective observational, longitudinal study of pregnant women with a major depressive disorder treated with sertraline (N = 185 women, 205 pregnancies ...
Sílvia M. Illamola, Zachary N. Stowe, Marc L. Kalin, Michael D. Evans, Catherine M. Sherwin, Maged M. Costantine, D. Jeffrey Newport, James C. Ritchie, Angela K. Birnbaum   +8 more
wiley   +1 more source

Psychoactive prescription drug use and misuse in patients on opioid agonist treatment

British Journal of Clinical Pharmacology, EarlyView.
Aims To identify the patterns and trends in prescription drug use and misuse in patients on opioid agonist treatment. Methods We used data from the OPPIDUM programme, which collects data from patients attending substance abuse treatment facilities. Data collected include use of psychoactive prescription drugs in the past week.
Thomas Soeiro, Clémence Lacroix, Élisabeth Jouve, Élisabeth Frauger, Maryse Lapeyre‐Mestre, Joëlle Micallef   +5 more
wiley   +1 more source

Phenobarbital Bioequivalence in Chinese Population: Considering the Role of Food on Pharmacokinetics

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Epilepsy is one of the most severe neurological disorders in the world, which might seriously endanger the lives of patients. Phenobarbital is an important medicine clinically used for the treatment of epilepsy, and it is irreplaceable in the treatment of generalized tonic–clonic seizures, focal seizures, status epilepticus, and pediatric ...
Wang Xinman, Liu Yuan, Sun Ying, Wang Yiyun   +3 more
wiley   +1 more source