Results 191 to 200 of about 4,656 (255)

Integration of lornoxicam nanocrystals into hydroxypropyl methylcellulose-based sustained release matrix to form a novel biphasic release system.

International Journal of Biological Macromolecules, 2022
The study aims to (a) enhance the solubility of a poorly soluble drug by optimization of nanocrystal formulation using the top-down approach and (b) modify the release profile of this drug, which exhibits a short elimination half-life, by the integration
Nguyen-Thach Tung, Thi-Hoang-Yen Dong, Cao-Son Tran, T. Nguyen, S. Chi, Danh Dao, D. Nguyen   +6 more
semanticscholar   +1 more source

A tragacanth gum-infused graphitic carbon nitride/cellulose nanohydrogel for controlled lornoxicam release kinetics

New Journal of Chemistry
Hydrogel biomaterials are increasingly utilized as drug delivery systems due to their unique properties.
Aamir Nawaz, M. Taj, Muhammad Imran Khan, Abeer M. Beagan, Antoniadou Maria, A. Shanableh   +5 more
semanticscholar   +1 more source

Lipid-chitosan hybrid nanoparticles for transdermal co-delivery of lornoxicam and curcumin in arthritis management.

International Journal of Biological Macromolecules
The transdermal drug delivery system (TDDS) is a promising approach with multiple advantages, including enhanced permeation and improved therapeutic outcomes. In this study, we developed lipid polymer hybrid nanoparticles (LPHNPs) co-loaded with curcumin
Arshad Khan, Asadullah Madni, Nauman Rahim Khan, Nasrullah Jan, Safiullah Khan, Hassan Shah, Muhammad Abdur Rahim, Ashraf Ullah Khan, A. Jabar   +8 more
semanticscholar   +1 more source

Comparative Assessment of Amine‐Functionalized KIT‐5 and KIT‐6 Mesoporous Silica as Carriers for Lornoxicam Adsorption and Release

ChemistrySelect
In this research, Mesoporous silica KIT‐5 and KIT‐6 were prepared using template sol–gel method. The synthesized particles were functionalized through post‐grafting method with (3‐Aminopropyl) trimethoxysilane (APTMS) to form (KIT5‐NH2) and (KIT6‐NH2) as
Ali H. Khalbas, T. Albayati, Issam K. Salih, H. S. Majdi   +3 more
semanticscholar   +1 more source

Clinical Pharmacokinetics of Lornoxicam

Clinical Pharmacokinetics, 1998
Lornoxican (chlorotenoxicam) is a nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class. Unlike other oxicams, lornoxicam has a relatively short plasma half-life (3 to 5 hours). Lornoxicam is eliminated following biotransformation to 5'-hydroxy-lornoxicam, which does not undergo enterohepatic recirculation.
N M, Skjodt, N M, Davies
openaire   +2 more sources

Regenerated cellulose fibers for preparation of alginate and lornoxicam-loaded medical knitted textiles: A response surface optimization study.

International Journal of Biological Macromolecules
Regenerated cellulose and alginate have been increasingly utilized to prepare medical textiles due to their biocompatibility. A 33-face-centered design was proposed to prepare and optimize alginate and lornoxicam (LRX)-loaded textiles using bamboo and ...
Ebtesam W. Elsayed, M. Emam, Manar Y. Abd El-Aziz, Heba Tolla El Sayed Abo El Naga, L. Emara   +4 more
semanticscholar   +1 more source

Preoperative peritonsillar lornoxicam infiltration is not superior to intravenous lornoxicam for pain relief following tonsillectomy in adults

European Journal of Anaesthesiology, 2010
Nonsteroidal anti-inflammatory drugs have peripheral analgesic effects. We compared the efficacy of peritonsillar infiltration versus intravenous (i.v.) lornoxicam on pain relief after tonsillectomy in adults.Sixty adult patients scheduled for tonsillectomy were randomly assigned into three groups in a double-blind placebo-controlled study.
Salah A, Ismail, Hany A, Mowafi
openaire   +2 more sources

Intra-articular Injection of Lornoxicam and MicroRNA-140 Co-loaded Cationic Liposomes Enhanced the Therapeutic Treatment of Experimental Osteoarthritis

AAPS PharmSciTech, 2021
Osteoarthritis is a chronic joint disease characterized by chronic inflammation, progressive destruction of articular cartilage, and subchondral bone sclerosis.
Kongfang He, Xiaoyu Huang, R. Shan, Xuehua Yang, Ruonan Song, Fei Xie, Guihua Huang   +6 more
semanticscholar   +1 more source

A novel soluble lornoxicam-sodium chelate monohydrate with improved plasticity and tabletability.

International journal of pharmaceutics, 2022
Lornoxicam (LOR), a BCS Ⅱ nonsteroidal anti-inflammatory drug, has been clinically utilized for moderate to severe acute pain management. However, it has poor water solubility and insufficient tabletability, leading to erratic absorption and challenge in
Hui Chen, Jingwen Zhang, Qiyang Qiao, Enshi Hu, Yuanfeng Wei, Zunting Pang, Yuan Gao, Shuai Qian, Jianjun Zhang, W. Heng   +9 more
semanticscholar   +1 more source

Development and In Vitro Assessment of a Pluronic-coconut Oil-lecithin Organogel for Topical Delivery of Lornoxicam in Managing Cervical Spondylosis

Drug Delivery Letters
Topical delivery via organogels offers a promising method to deliver Lornoxicam directly to the target site with improved bioavailability, avoiding the issues associated with systemic administration.
Yeshna, Monika Singh, Monika, Ankit Bansal, Samrat Chauhan, Rohit Dutt, V. Jhawat   +6 more
semanticscholar   +1 more source