Results 191 to 200 of about 28,228 (226)
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Drugs, 2003
Losartan is an orally active, selective, nonpeptide, angiotensin II AT(1) receptor antagonist. Losartan 50 or 100 mg/day was significantly more effective than placebo in reducing the incidence of a doubling of serum creatinine, end-stage renal disease (ESRD) or death (43.5% vs 47.1%, p = 0.02) in a pivotal, well designed trial (Reduction of Endpoints ...
Karen L. Goa, Christopher I. Carswell
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Losartan is an orally active, selective, nonpeptide, angiotensin II AT(1) receptor antagonist. Losartan 50 or 100 mg/day was significantly more effective than placebo in reducing the incidence of a doubling of serum creatinine, end-stage renal disease (ESRD) or death (43.5% vs 47.1%, p = 0.02) in a pivotal, well designed trial (Reduction of Endpoints ...
Karen L. Goa, Christopher I. Carswell
openaire +4 more sources
Annals of Pharmacotherapy, 1999
OBJECTIVE: To report a case of angioedema associated with the angiotensin II receptor antagonist losartan. CASE SUMMARY: A 62-year-old African-American woman was admitted to the hospital for acute renal failure and uncontrolled hypertension. After attempting blood pressure control with three different agents, captopril was combined with metoprolol. The
Yoon Ju Cha, Vincent Earl Pearson
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OBJECTIVE: To report a case of angioedema associated with the angiotensin II receptor antagonist losartan. CASE SUMMARY: A 62-year-old African-American woman was admitted to the hospital for acute renal failure and uncontrolled hypertension. After attempting blood pressure control with three different agents, captopril was combined with metoprolol. The
Yoon Ju Cha, Vincent Earl Pearson
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Clinical Pharmacokinetics of Losartan
Clinical Pharmacokinetics, 2005Losartan is the first orally available angiotensin-receptor antagonist without agonist properties. Following oral administration, losartan is rapidly absorbed, reaching maximum concentrations 1-2 hours post-administration. After oral administration approximately 14% of a losartan dose is converted to the pharmacologically active E 3174 metabolite.
Domenic A. Sica +2 more
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Losartan-induced bronchospasm☆☆☆★
Journal of Allergy and Clinical Immunology, 19967. Askenase PW. Effector and regulatory mechanisms in delayed-type hypersensitivity. In: Middleton E Jr, Reed CE, Ellis EF, Adkinson NF Jr, Yunginger JW, Busse WW, editors. Allergy: principles and practice. 4th ed. St. Louis: Mosby, 1993:362-89. 8. Marcussen PV. Relationship of the urticarial to the inflammatory reaction to trichophyton.
Michael B. Sherman +4 more
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Losartan in Cushing's syndrome
Methods and Findings in Experimental and Clinical Pharmacology, 1998Eleven patients with Cushing's syndrome were included in the study. They maintained their usual sodium intake and received a single oral dose of 50 mg of the angiotensin II antagonist receptor losartan for 3 days. Losartan treatment resulted in stimulation of active renin and decrease of plasma and urinary kallikrein activity.
Orbetzova M +8 more
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Losartan in diabetic nephropathy
Expert Review of Cardiovascular Therapy, 2004Diabetic nephropathy has become the single most important cause of end-stage renal disease in the USA, Europe and Japan. The earliest marker of incipient diabetic nephropathy is the transition of normoalbuminuria to microalbuminuria at an albumin excretion rate of 20 microg/min.
Norberto Perico +2 more
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2015
Losartan (Cozaar™) is an angiotensin II receptor antagonist with antihypertensive activity. It is used in the management of hypertension and heart failure. Nomenclature, formulae, elemental analysis, and appearance of the drug are included in this review. The uses, applications, and the variety of synthetic pathways of this drug are outlined.
Hatem A. Abdel-Aziz +3 more
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Losartan (Cozaar™) is an angiotensin II receptor antagonist with antihypertensive activity. It is used in the management of hypertension and heart failure. Nomenclature, formulae, elemental analysis, and appearance of the drug are included in this review. The uses, applications, and the variety of synthetic pathways of this drug are outlined.
Hatem A. Abdel-Aziz +3 more
openaire +3 more sources