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Journal of Ocular Pharmacology and Therapeutics, 2023
Losartan is an angiotensin II receptor blocker (ARB) that impedes transforming growth factor (TGF) beta signaling by inhibiting activation of signal transduction molecule extracellular signal-regulated kinase (ERK).
S. Wilson
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Losartan is an angiotensin II receptor blocker (ARB) that impedes transforming growth factor (TGF) beta signaling by inhibiting activation of signal transduction molecule extracellular signal-regulated kinase (ERK).
S. Wilson
semanticscholar +1 more source
Angiotensin receptor blocker Losartan inhibits tumor growth of colorectal cancer
EXCLI Journal : Experimental and Clinical Sciences, 2021The renin-angiotensin system (RAS) is up-regulated in patients with colorectal cancer (CRC) and is reported to be associated with poor prognosis and chemo-resistance.
M. Hashemzehi +13 more
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American Journal of Sports Medicine, 2021
Background: A previous publication demonstrated that the oral intake of losartan promoted microfracture-mediated hyaline-like cartilage repair in osteochondral defects of a rabbit knee model.
Catherine A. Logan +11 more
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Background: A previous publication demonstrated that the oral intake of losartan promoted microfracture-mediated hyaline-like cartilage repair in osteochondral defects of a rabbit knee model.
Catherine A. Logan +11 more
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Annals of Pharmacotherapy, 1999
OBJECTIVE: To report a case of angioedema associated with the angiotensin II receptor antagonist losartan. CASE SUMMARY: A 62-year-old African-American woman was admitted to the hospital for acute renal failure and uncontrolled hypertension. After attempting blood pressure control with three different agents, captopril was combined with metoprolol. The
Yoon Ju Cha, Vincent Earl Pearson
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OBJECTIVE: To report a case of angioedema associated with the angiotensin II receptor antagonist losartan. CASE SUMMARY: A 62-year-old African-American woman was admitted to the hospital for acute renal failure and uncontrolled hypertension. After attempting blood pressure control with three different agents, captopril was combined with metoprolol. The
Yoon Ju Cha, Vincent Earl Pearson
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Drugs, 2003
Losartan is an orally active, selective, nonpeptide, angiotensin II AT(1) receptor antagonist. Losartan 50 or 100 mg/day was significantly more effective than placebo in reducing the incidence of a doubling of serum creatinine, end-stage renal disease (ESRD) or death (43.5% vs 47.1%, p = 0.02) in a pivotal, well designed trial (Reduction of Endpoints ...
Karen L. Goa, Christopher I. Carswell
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Losartan is an orally active, selective, nonpeptide, angiotensin II AT(1) receptor antagonist. Losartan 50 or 100 mg/day was significantly more effective than placebo in reducing the incidence of a doubling of serum creatinine, end-stage renal disease (ESRD) or death (43.5% vs 47.1%, p = 0.02) in a pivotal, well designed trial (Reduction of Endpoints ...
Karen L. Goa, Christopher I. Carswell
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Clinical Pharmacokinetics of Losartan
Clinical Pharmacokinetics, 2005Losartan is the first orally available angiotensin-receptor antagonist without agonist properties. Following oral administration, losartan is rapidly absorbed, reaching maximum concentrations 1-2 hours post-administration. After oral administration approximately 14% of a losartan dose is converted to the pharmacologically active E 3174 metabolite.
Domenic A. Sica +2 more
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American Journal of Sports Medicine, 2020
Background: Microfracture or bone marrow stimulation (BMS) is often the first choice for clinical treatment of cartilage injuries; however, fibrocartilage, not pure hyaline cartilage, has been reported because of the development of fibrosis in the repair
Hajime Utsunomiya +12 more
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Background: Microfracture or bone marrow stimulation (BMS) is often the first choice for clinical treatment of cartilage injuries; however, fibrocartilage, not pure hyaline cartilage, has been reported because of the development of fibrosis in the repair
Hajime Utsunomiya +12 more
semanticscholar +1 more source
Losartan in Cushing's syndrome
Methods and Findings in Experimental and Clinical Pharmacology, 1998Eleven patients with Cushing's syndrome were included in the study. They maintained their usual sodium intake and received a single oral dose of 50 mg of the angiotensin II antagonist receptor losartan for 3 days. Losartan treatment resulted in stimulation of active renin and decrease of plasma and urinary kallikrein activity.
Orbetzova M +8 more
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