Results 121 to 130 of about 114,870 (312)

Evaluating trade-offs between COVID-19 prevention and learning loss: an agent-based simulation analysis

Royal Society Open Science
The COVID-19 pandemic presented significant challenges in educational settings. Schools implemented a variety of COVID-19 mitigation strategies, some of which were controversial due to potential disruptions to in-person learning.
Kenneth Chen, Eva A. Enns
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Mitigating Losses in Hyperbolic Asymptotic Eigenmodes

Advanced Photonics Research
Materials exhibiting hyperbolic dispersion have attracted considerable interest within the optical and quantum communities due to their potential to confine electromagnetic waves at subwavelength scales, thereby surpassing the diffraction limit. This capability arises from the support of high‐k (i.e., wavevector) eigenmodes in hyperbolic materials ...
Lu Song, Huaping Wang, Yingjie Wu, Tong Cai, Jiangang Liang, Lian Shen   +5 more
openaire   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Optimal wildfire insurance in the wildland-urban interface in the presence of a government subsidy for fire risk mitigation [PDF]

We investigate the effectiveness of a government subsidy and mitigation based insurance contracts at discouraging migration into the wildland interface and at inducing incentives for risk mitigation.
Mariam Lankoande, Jonathan Yoder, Philip Wandschneider   +2 more
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Evaluating Lotteries, Risks, and Risk-mitigation Programs [PDF]

Two experiments were designed to explore the existence of systematic differences in risk perceptions and risk attitudes between Chinese and U.S. participants.
Fischbeck, Paul, Wang, Mei
core  

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

THE DOUBLE TRADE-OFF BETWEEN ADAPTATION AND MITIGATION FOR SEA LEVEL RISE: AN APPLICATION OF FUND [PDF]

The effects of adaptation and mitigation on the impacts of sea level rise are studied. Without either, the impacts of sea level rise would be substantial, almost wiping out entire nations before 2100; the global effect is much smaller.
Richard S.J. Tol
core