EBioMedicineSummary: Background: Loss of heterozygosity (LOH) diminishes genetic diversity within cancer genomes. A tumour arising in an individual heterozygous for a functional and a loss-of-function (LoF) allele of a gene occasionally retain only the LoF allele ...
Xiaonan Zhang +18 more
doaj
Different Incidence of Loss of Heterozygosity on Chromosome 16q between Intraductal Papilloma and Intracystic Papillary Carcinoma of the Breast [PDF]
, 1994 Hitoshi Tsuda +3 more
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Whole-Exome Sequencing Study of Thyrotropin-Secreting Pituitary Adenomas [PDF]
, 2018 学位記番号 ...
Santosh, Sapkota +2 more
core
Advanced Science, EarlyView.RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang +7 more
wiley +1 more source
Analysis of proto-oncogenes in acute myeloid leukemia: loss of heterozygosity for the Ha-ras gene [PDF]
, 1990 HG Ahuja, A Foti, DJ Zhou, MJ Cline
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Epigenetic Regulation of DAPK1 and Netrin‐1 Drives Diabetic Encephalopathy
Advanced Science, EarlyView.This study identifies a microRNA (miR)‐216a‐5p/death‐associated protein kinase 1 (DAPK1)/hepatocyte nuclear factor 1 homeobox A (HNF1A)/Netrin‐1 signaling axis in diabetic encephalopathy (DE). In leptin receptor‐deficient (db/db) and streptozotocin (STZ)‐induced diabetic mice, reduced miR‐216a‐5p increases DAPK1 expression, disrupting HNF1A binding to ...
Yang Zhou +13 more
wiley +1 more source
Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa
Advanced Science, EarlyView.Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang +13 more
wiley +1 more source
Loss of heterozygosity and microsatellite instability as predictive markers among Iranian esophageal cancer patients [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): Variation in microsatellite sequences that are dispersed in the genome has been linked to a deficiency in cellular mismatch repair system and defects in several genes of this system are involved in carcinogenesis.
Mohammad Mahdi Forghanifard +7 more
doaj
Molecular Backgrounds of ERAP1 Downregulation in Cervical Carcinoma
Analytical Cellular Pathology, 2015 The antigen processing machinery (APM) plays an important role in immune recognition of virally infected and transformed cells. Defective expression of the APM component ERAP1 is associated with progression and poor clinical outcome in cervical carcinoma.
Akash M. Mehta +4 more
doaj +1 more source
Loss of heterozygosity on chromosome arm 17p in small cell lung carcinomas, but not in neurofibromas, in a patient with von recklinghausen neurofibromatosis [PDF]
, 1993 Eiji Shimizu +7 more
openalex +1 more source