Results 121 to 130 of about 137,449 (345)

Loss of heterozygosity at 9p and p53 immunopositivity in surgical margins predict local relapse in head and neck squamous cell carcinoma [PDF]

, 2010
A. Peggy Graveland, Paweł Golusiński, Marijke Buijze, Rinze Douma, Nanet Sons, Dirk J. Kuik, Elisabeth Bloemena, C. René Leemans, Ruud H. Brakenhoff, Boudewijn J.M. Braakhuis   +9 more
openalex   +1 more source

Status of reintroduced American marten in the Manistee National Forest within Michigan’s Northern Lower Peninsula [PDF]

, 2012
American martens (Martes americana) were extirpated from the Lower Peninsula of Michigan as a result of overharvest for fur and habitat loss in the early 1900s.
Watkins, Julie M.
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Villin like suppresses nasopharyngeal carcinoma proliferation by downregulating MYC

Scientific Reports
The initial manifestations of nasopharyngeal carcinoma (NPC) are subtle and imperceptible, leading to unfavorable clinical outcomes and limited therapeutic alternatives among Southeast Asian populations.
Yueting Wen, Ziying Zhou, Yibo Zhou, Zhongxi Huang   +3 more
doaj   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Application of Chromosomal Microarray Analysis in Genetic Reasons of Miscarriage Tissues

The Application of Clinical Genetics
Zhen Xu,1– 3 Na Liu,1– 3 Lu Gao,1– 3 Dongyi Yu1– 3 1Center for Medical Genetics and Prenatal Diagnosis, Shandong Provincial Maternal and Child Health Care Hospital, Affiliated to Qingdao University, Jinan, Shandong, 250000, People’s Republic of China ...
Xu Z, Liu N, Gao L, Yu D
doaj  

The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity [PDF]

, 2021
Luiza Sheyla Evenni Porfírio Will Castro, Wietske Pieters, Mir Farshid Alemdehy, Muhammad Assad Aslam, Olimpia Alessandra Buoninfante, Jonne A. Raaijmakers, Bas Pilzecker, Paul C.M. van den Berk, Hein te Riele, René H. Medema, Rozangela Curi Pedrosa, Heinz Jacobs   +11 more
openalex   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source