Results 101 to 110 of about 137,449 (345)

Continental-scale patterns of pathogen prevalence: a case study on the corncrake [PDF]

, 2014
Pathogen infections can represent a substantial threat to wild populations, especially those already limited in size. To determine how much variation in the pathogens observed among fragmented populations is caused by ecological factors, one needs to ...
Barton K., Bates D., Beaumont M. A., Burnham K. P., Coltman D., Goudet J., Green R. E., Green R. E., Schäffer N., Valkiūnas G.   +9 more
core   +2 more sources

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Review for "Aneuploidy and loss of heterozygosity as risk markers for malignant transformation in oral mucosa"

, 2021

openalex   +1 more source

Microsatellite Instability and Loss of Heterozygosity in Melanoma

Journal of Investigative Dermatology, 1995
Alterations in the repeat length of microsatellites have been identified recently in tumors arising in patients with hereditary nonpolyposis colon cancer and in several human sporadic tumors. We examined 40 sporadic melanomas and their corresponding nontumorous skin for microsatellite instability (MSI) and loss of heterozygosity (LOH) at chromosomes 2q,
Peris, Ketty, Keller, G, Chimenti, S, Amantea, A, Kerl, H, Höfler, H.   +5 more
openaire   +3 more sources

Assessing the sensitivity and the clinical impact of the 2023 ACR/EULAR classification criteria in Obstetric Antiphospholid Syndrome: findings from a multicenter Italian cohort with a long‐term follow‐up

Arthritis Care &Research, Accepted Article.
Objective To evaluate the sensitivity of the 2023 ACR/EULAR classification criteria for antiphospholipid syndrome (APS) in a real‐world cohort of women diagnosed with primary obstetric APS (oAPS), and to assess their ability to identify patients at risk of future pregnancy complications.
Francesca Ruffilli, Cecilia Nalli, Francesca Crisafulli, Carlo Garaffoni, Marcello Govoni, Giulia Voltarel, Alba C. Pozzi, Beatrice Maranini, Ettore Silvagni, Alessandra Bortoluzzi, Angela Tincani   +10 more
wiley   +1 more source

Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers

Nature Communications, 2016
Using mosaic analysis with double markers to label genetically-distinct clones in established tumors, the authors studied the effects of p53 loss in lung and pancreatic cancers.
Mandar Deepak Muzumdar, Kimberly Judith Dorans, Katherine Minjee Chung, Rebecca Robbins, Tuomas Tammela, Vasilena Gocheva, Carman Man-Chung Li, Tyler Jacks   +7 more
doaj   +1 more source

Discovery of non-climacteric and suppressed climacteric bud sport mutations originating from a climacteric Japanese plum cultivar (Prunus salicina Lindl.). [PDF]

, 2015
Japanese plums are classified as climacteric; however, some economically important cultivars selected in California produce very little ethylene and require long ripening both "on" and "off" the tree to reach eating-ripe firmness. To unravel the ripening
Abdi, Abdi, Ahmad, Aranzana, Atkinson, Ayub, Begheldo, Burg, Candan, Carrasco, Casas, Chalmers, Chervin, Cipriani, Crisosto, Crisosto, Crisosto, Crisosto, Crisosto, Crisosto, Dandekar, Dangl, Dirlewanger, Dirlewanger, Dondini, El-Sharkawy, El-Sharkawy, El-Sharkawy, El-Sharkawy, Fernández i Martí, Fernández i Martí, Font i Forcada, Giovannoni, Giovannoni, Giovannoni, Grierson, Grossman, Herner, Hormaza, Kimura, Klee, Lelievre, Manganaris, Marcotrigiano, Martinez-Romero, McGlasson, McMurchie, Miller, Minas, Mnejja, Nei, Oeller, Okie, Okie, Osorio, Picton, Porat, Riaz, Rohlf, Ruthner, Selvarajah, Singh, Sisler, Solano, Tatsuki, Testolin, Tian, Tohge, Tonutti, Trainotti, Walker, Wang, Watkins, Yeh   +73 more
core   +3 more sources

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Single-Gene Deletions Contributing to Loss of Heterozygosity in Saccharomyces cerevisiae: Genome-Wide Screens and Reproducibility

G3: Genes, Genomes, Genetics, 2019
Loss of heterozygosity (LOH) is a phenomenon commonly observed in cancers; the loss of chromosomal regions can be both causal and indicative of underlying genome instability.
Kellyn M. Hoffert, Erin D. Strome
doaj   +1 more source