Results 91 to 100 of about 137,449 (345)

Voter models with heterozygosity selection

, 2008
This paper studies variations of the usual voter model that favor types that are locally less common. Such models are dual to certain systems of branching annihilating random walks that are parity preserving.
Sturm, Anja, Swart, Jan
core   +2 more sources

Venetian local corn (Zea mays L.) germplasm: Disclosing the genetic anatomy of old landraces suited for typical cornmeal mush production. [PDF]

, 2017
Due to growing concern for the genetic erosion of local varieties, four of the main corn landraces historically grown in Veneto (Italy) \u2014 Sponcio, Marano, Biancoperla and Rosso Piave \u2014 were characterized in this work.
Barcaccia, Gianni, Galla, Giulio, Mart\ued\uadnez-Bello, Liliam, Palumbo, Fabio   +3 more
core   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Positional and functional mapping of a neuroblastoma differentiation gene on chromosome 11 [PDF]

, 2005
Background: Loss of chromosome 11q defines a subset of high-stage aggressive neuroblastomas. Deletions are typically large and mapping efforts have thus far not lead to a well defined consensus region, which hampers the identification of positional ...
De Preter, K, Vandesompele, J, Menten, B, Carr, P, Fiegler, H, Edsjö, Anders,, Carter, NP, Yigit, N, Waelput, W, Van Roy, N, Bader, S, Påhlman, Sven,, Speleman, F, Lund University.   +13 more
core   +3 more sources

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Loss of heterozygosity in acute leukemia: evidence of frequent submicroscopic deletions

Haematologica, 2007
Although chromosomal abnormalities are detected by conventional cytogenetic analysis (CCA) in 40–60% of patients with acute myeloid leukemia (AML), cryptic chromosomal deletions may only be detected by molecular analysis. To determine their frequency, we
Cecilia Agueli, Rosaria Basiricò, Francesco Fabbiano, Valentina Rizzo, Lucia Cascio, Giuseppe Cammarata, Anna Marfia, Maria La Rosa, Salvo Mirto, Alessandra Santoro   +9 more
doaj   +1 more source

Invasion of Europe by the western corn rootworm, Diabrotica virgifera virgifera: multiple transatlantic introductions with various reductions of genetic diversity [PDF]

, 2008
The early stages of invasion involve demographic bottlenecks that may result in lower genetic variation in introduced populations as compared to source population/s. Low genetic variability may decrease the adaptive potential of such populations in their
Arnaud-Haond, Ayala, Bossdorf, Branson, Cadotte, Cheek, Chen, Cox, Dlugosch, Estoup, Facon, Falconer, Fonseca, Genton, Grevstad, Holland, Johnson, Kang, Kelly, Kim, Kim, Kim, Kiss, Kiss, Kolbe, Krysan, Krysan, Leberg, Levine, Lindholm, Lockwood, McKay, McKinney, Meinke, Merila, Metcalf, Miller, Miller, Nei, Novak, Olden, Ostoja-Starzewski, Paetkau, Parimi, Pascual, Pimentel, Piry, Rannala, Raymond, Raymond, Reed, Reznick, Roman, Roman, Ross, Ruiz, Sax, Schierenbeck, Smith, Sokal, Spencer, Stockwell, Sunnucks, Tsutsui, Van Rozen, Voisin, Wares, Weir, Zayed   +68 more
core   +3 more sources

Loss Of Heterozygosity

, 2014
Author: Molecular Profiling Initiative, NCI *This method was successful in our lab using prostate tissue and for our specific objectives. Investigators must be aware that they will need to tailor the following protocol for their own research objectives and tissue under study*. This method is used to detect genomic DNA deletions in tumor cells.
openaire   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Genetic Profiling Uncovers Genome-Wide Loss of Heterozygosity and Provides Insight into Mechanisms of Sarcomatoid Transformation in Chromophobe Renal Cell Carcinoma [PDF]

, 2023
Katrina Collins, Andrés Acosta, Stephanie Siegmund, Liang Cheng, Michelle S. Hirsch, Muhammad T. Idrees   +5 more
openalex   +1 more source