Results 111 to 120 of about 137,449 (345)

Supplementary Data from Loss of Heterozygosity at 2q37 in Sporadic Wilms' Tumor: Putative Role for <i>miR-562</i>

, 2023
Kylie M. Drake, E. Cristy Ruteshouser, Rachael Natrajan, Phyllis Harbor, Jenny Wegert, Manfred Gessler, Kathy Pritchard‐Jones, Paul Grundy, Jeffrey S. Dome, Vicki Huff, Chris Jones, Micheala A. Aldred   +11 more
openalex   +1 more source

Mapping of Multiple DNA Gains and Losses in Primary Small Cell Lung Carcinomas by Comparative Genomic Hybridization [PDF]

, 1994
Comparative genomic hybridization was applied for a comprehensive screening of under- and overrepresentation of genetic material in 13 autoptic small cell lung cancer specimens.
Cremer, Thomas, Holtgreve-Grez, Heidi, Manoir, Stanislas du, Petersen, Iver, Ried, Thomas, Schröck, Evelin, Speicher, Michael R.   +6 more
core  

SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination [PDF]

, 2016
Homologous recombination (HR) is essential for maintenance of genome stability through double-strand break (DSB) repair, but at the same time HR can lead to loss of heterozygosity and uncontrolled recombination can be genotoxic.
Lisby, Michael, Silva, Sonia
core   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Prognostic impact of biomarkers in PMBCL: rationale for early integration of immune checkpoint inhibitors [PDF]

Exploration of Targeted Anti-tumor Therapy
Aim: This research aims to guide future strategies for personalized treatment of primary mediastinal large B-cell lymphoma (PMBCL), particularly to identify high-risk patients who may benefit from incorporating immune checkpoint inhibitors (ICIs) in the ...
Yana K. Mangasarova, Runiza R. Abdurashidova, Natalya V. Risinskaya, Bella V. Biderman, Tatiana V. Abramova, Vadim L. Surin, Irina A. Shupletsova, Tatiana N. Obukhova, Rasul I. Iusupov, Yulia A. Chabaeva, Aminat U. Magomedova, Lena E. Nikulina, Sergei M. Kulikov, Eugene E. Zvonkov, Alla M. Kovrigina, Andrey B. Sudarikov   +15 more
doaj   +1 more source

Host-race specificity in the endemic pygmy mistletoe Korthalsella salicornioides (Viscaceae) : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Plant Biology at Massey University, Palmerston North, New Zealand [PDF]

, 2016
Korthalsella Tiegh. is a genus of stem hemiparasites in the family Viscaceae, represented in New Zealand by three endemic species: K. clavata, K. lindsayi, and K. salicornioides. The most host-specific is K.
Pearson, Sofie Margaret
core  

High Genetic Diversity and Low Differentiation of Michelia coriacea (Magnoliaceae), a Critically Endangered Endemic in Southeast Yunnan, China [PDF]

, 2012
Michelia coriacea, a critically endangered tree, has a restricted and fragmented distribution in Southeast Yunnan Province, China. The genetic diversity, genetic structure and gene flow in the three extant populations of this species were detected by 10 ...
Archak, Bauert, Belaj, Benor, Budak, Chen, Chiang, Cicuzza, Dan, Dong, Doyle, Evanno, Excoffier, Frankel, Ge, Godt, Hamrick, Ikegami, Kikuchi, Kingston, Lande, Liao, Liu, Loveless, Lu, Luan, Ma, Maguire, Nei, Neigel, Nybom, Peakall, Powell, Pritchard, Qiao, Raymond, Richard Milne, Rossetto, Schaal, Shui, Sun, Sun, Wang, Weibang Sun, Whitlock, Wu, Xiangying Wen, Xingfeng Zhao, Yao, Yeh, Yongpeng Ma, Zawko, Zhang, Zhao, Zhou   +54 more
core   +3 more sources

An Open‐Source Pipeline for Calcium Imaging and All‐Optical Physiology in Human Stem Cell‐Derived Neurons

Advanced Science, EarlyView.
This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber, Federico M. Gasparoli, Ziqin Yang, Nicole A. Teaney, Rachel Hobson, Lahin Lalani, Gayathri Srinivasan, Dosh Whye, Ranit Karmakar, Elizabeth D. Buttermore, Kellen D. Winden, Cidi Chen, Mustafa Sahin   +12 more
wiley   +1 more source

Histone Mutants Separate R Loop Formation from Genome Instability Induction [PDF]

, 2017
R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms for this are unknown. Here we identified yeast histone H3 and H4 mutations that facilitate R loops but do not cause instability.
Aguilera López, Andrés, Cañas, Juan C., García Pichardo, Desiré, García Rondón, Ana, García Rubio, María Luisa, Gómez González, Belén   +5 more
core   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source