Results 221 to 230 of about 72,863 (253)

Loss of heterozygosity for chromosome 14q in neuroblastoma

Medical and Pediatric Oncology, 2001
Neuroblastoma is a genetically heterogeneous disease, with subsets of tumors demonstrating rearrangements of several genomic regions. Preliminary studies from several groups have identified loss of heterozygosity (LOH) for the long arm of chromosome 14 (14q) in 20-25% of primary neuroblastomas.To determine precisely the frequency and extent of 14q ...
P M, Thompson, B A, Seifried, S K, Kyemba, S J, Jensen, C, Guo, J M, Maris, G M, Brodeur, D O, Stram, R C, Seeger, R, Gerbing, K K, Matthay, T C, Matise, P S, White   +12 more
openaire   +2 more sources

Loss of Heterozygosity in Bilateral Breast Cancer

Breast Cancer Research and Treatment, 2000
Women who develop bilateral breast cancer at an early age are likely to harbour germline mutations in breast cancer susceptibility genes. The aim of this study was to test for concordant genetic changes in left and right breast cancer of young women (age < 50) with bilateral breast cancer that may suggest an inherited breast cancer predisposition ...
J, Kollias, S, Man, M, Marafie, K, Carpenter, S, Pinder, I O, Ellis, R W, Blamey, G, Cross, J D, Brook   +8 more
openaire   +2 more sources

Loss of constitutional heterozygosity in human astrocytomas

Acta Neurochirurgica, 1992
Inactivation of tumour suppressor genes or anti-oncogenes as well as activation of dominant acting oncogenes seem to be important mechanisms in the pathogenesis of gliomas. We compared constitutional and tumoural genotypes at different restriction fragment length polymorphism loci (RFLP) on chromosomes 10 and 17 in 15 unrelated individuals.
van de Kelft, E., de Boulle, K., Willems, P., Martin, J.-J., Selosse, P., van der Auwera, B.   +5 more
openaire   +3 more sources

Analysis of Loss of Heterozygosity in Circulating DNA

2009
Analysis of genetic altera tion in circulating DNA can have clinical utility in predicting disease outcome. Loss of heterozygosity (LOH) of DNA microsatellites has been shown to occur commonly among all chromosomes in various cancers, such as melanoma, breast cancer, and lung cancer.
Takeshi, Nakamura, Eiji, Sunami, Tuny, Nguyen, Dave S B, Hoon   +3 more
openaire   +2 more sources

Loss of somatic heterozygosity in hepatocellular carcinoma.

Cancer research, 1991
Loss of tumor suppressor genes is involved in the mechanism of tumorigenesis of many solid tumors. We tested 9 hepatitis B virus (HBV)-positive and 10 HBV-negative hepatocellular carcinomas for loss of somatic heterozygosity using 14 polymorphic probes mapping to chromosomes 4, 11, 13, and 17. Losses were found on all chromosome arms tested.
Walker, Graeme J., Hayward, Nicholas K., Falvey, Scott, Cooksley, W. Graham E.   +3 more
openaire   +2 more sources

Loss of Heterozygosity

2013
Steven J. Frampton, Emma V. King
openaire   +2 more sources

Loss of heterozygosity in tertiary hyperparathyroidism

Transplantation Proceedings, 2002
E, Konya, H, Tsuji, N, Amasaki, T, Umekawa, M, Iguchi, T, Kurita   +5 more
openaire   +2 more sources

Loss of heterozygosity for chromosome 11 in adenocarcinoma of the stomach.

Cancer research, 1996
Loss of heterozygosity (LOH) at several chromosomal loci is a common feature of the malignant progression of human tumors. In the case of chromosome 11, LOH has been well documented in several types of solid neoplasms, including gastric carcinoma, suggesting the presence of suppressor gene(s) at 11p15 and 11q22-23.
BAFFA R., NEGRINI, Massimo, MANDES B., RUGGE M., RANZANI G. N., HIROHASHI S., CROCE, Carlo Maria   +6 more
openaire   +3 more sources

Loss of Heterozygosity

2006
openaire   +2 more sources

Loss of Heterozygosity

2011
openaire   +2 more sources