Results 291 to 300 of about 138,753 (343)

PEK14: A Kinesin‐4 Necessary for Male‐Derived Fertility in Arabidopsis thaliana

Cytoskeleton, EarlyView.
ABSTRACT Of the 61 kinesins annotated in Arabidopsis thaliana, many are still without assigned function. Here, we have screened an insertional mutant library of Arabidopsis pollen‐expressed kinesins for fertility defects. Insertional mutants for three kinesins showed a significant reduction in seed set.
Isabella N. Mendes, Norman R. Groves, Jessica Z. Li, Lily N. Thompson, Brian J. Smith, Aman Y. Husbands, Iris Meier   +6 more
wiley   +1 more source

LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation

Cytoskeleton, EarlyView.
ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda, Joana N. Bugalhao, Marco Antonio Dias Louro, Andreia Henriques‐Soares, Monica Bettencourt‐Dias   +4 more
wiley   +1 more source

Extent of DNA damage induction by Raw betel_nut extract in mammalian cells and loss of heterozygosity at chromosome 9p in oral and esophageal carcinoma in raw betel_nut chewers

, 2008
Allen J. Freddy
openalex   +1 more source

Comparison of loss of heterozygosity patterns in primary oral premalignancy and premalignancy adjacent to oral cancer

, 2002
Ming Yeung Chau
openalex   +1 more source

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Loss of Heterozygosity

2009
The most common molecular alteration observed in human cancers,1 loss of heterozygosity (LOH), is a significant mecha-nism by which critical genes involved in growth regulation and homeostasis become inactivated, or silenced, during disease evolution. This chapter provides a review of LOH and its implications in various cancers as well as a review of ...
Belinda J. Wagner, Sharon C. Presnell
openaire   +2 more sources

Loss of heterozygosity by SCRaMbLEing

Science China Life Sciences, 2019
Genetic variation drives phenotypic evolution within populations. Genetic variation can be divided into different forms according to the size of genomic changes. However, study of large-scale genomic variation such as structural variation and aneuploidy is still limited and mainly based on the static, predetermined feature of individual genomes.
Yunxiang, Li, Yi, Wu, Lu, Ma, Zhou, Guo, Wenhai, Xiao, Yingjin, Yuan   +5 more
openaire   +2 more sources

LOHAS: loss‐of‐heterozygosity analysis suite

Genetic Epidemiology, 2011
AbstractDetection of loss of heterozygosity (LOH) plays an important role in genetic, genomic and cancer research. We develop computational methods to estimate the proportion of homozygous SNP calls, identify samples with structural alterations and/or unusual genotypic patterns, cluster samples with close LOH structures and map the genomic segments ...
Hsin-Chou, Yang, Lun-Ching, Chang, Richard M, Huggins, Chun-Houh, Chen, Charles G, Mullighan   +4 more
openaire   +2 more sources

Loss of Heterozygosity in Endometrial Carcinoma

International Journal of Gynecological Pathology, 2008
Inactivation of a tumor suppressor gene typically occurs in two steps, thus fulfilling Knudson hypothesis. One "hit" is frequently a point mutation or a small deletion. The other alteration is usually a large genomic loss of part of a gene, or even part of a chromosome, or the whole chromosome.
Ana, Velasco, Judit, Pallares, Maria, Santacana, Andre, Yeramian, Xavier, Dolcet, Nuria, Eritja, Soraya, Puente, Anabel, Sorolla, Nuria, Llecha, Xavier, Matias-Guiu   +9 more
openaire   +2 more sources

Loss of heterozygosity in liver tumours

Journal of Hepatology, 1995
ARCINOGENESIS is a multifactorial and multistep C process. In the process genetic factors play a pivotal role. There is a wealth of evidence that cancer is a set of fundamentally genetic diseases (1,2). While about 1% of total cancer patients inherit their tumours (3), genetic abnormalities have been demonstrated in all types of cancers, either ...
S F, Ding, N A, Habib
openaire   +2 more sources