Results 301 to 310 of about 138,753 (343)

Mechanisms of loss of heterozygosity in retinoblastoma

Cytogenetic and Genome Research, 1992
Retinoblastoma (RB) tumors arise when both alleles of the RBI gene are inactivated by two mutational events (Ml and M2). Ml can be an initial germline or somatic mutation; M2 is frequently loss of heterozygosity (LOH), which makes the cell homozygous or hemizygous for the original mutation. LOH is the major mechanism by which many cancers are initiated.
X, Zhu, J M, Dunn, A D, Goddard, J A, Squire, A, Becker, R A, Phillips, B L, Gallie   +6 more
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Loss of heterozygosity in Neuroblastomas—an Overview

European Journal of Cancer, 1997
Although previous studies have demonstrated a relatively high incidence of loss of heterozygosity (LOH) on chromosomes 1p, 11q and 14q in neuroblastoma, it is unclear whether LOH occurs specifically on these chromosomes or not. It might be due to the lack of allelotyping of neuroblastoma. When we assessed all 22 autosomes and chromosome X for LOH in 81
J, Takita, Y, Hayashi, J, Yokota
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Loss of heterozygosity in human skin

Journal of the American Academy of Dermatology, 1999
Loss of heterozygosity (LOH) is a genetic mechanism by which a heterozygous somatic cell becomes either homozygous or hemizygous because the corresponding wild-type allele is lost. LOH has today been recognized as a major cause of malignant growth. This article gives a comprehensive review of skin disorders in which an origin from LOH has been either ...
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Loss of heterozygosity analysis in malignant gliomas

Brain Tumor Pathology, 2011
Despite recent advances in the diagnosis and treatment of glioblastomas, patient outcomes for these highly malignant tumors remain poor. Research into the molecular pathology of glioblastoma has uncovered various genetic changes that contribute to malignancy.
Masahiro, Mizoguchi, Daisuke, Kuga, Yanlei, Guan, Nobuhiro, Hata, Akira, Nakamizo, Koji, Yoshimoto, Tomio, Sasaki   +6 more
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Loss of heterozygosity in human germinal tumors

Cytogenetic and Genome Research, 1989
The frequency of losses of heterozygosity has been investigated in 14 germinal tumors of the testis. Nonrandom deletion of whole or part of chromosome 11 was observed in four cases. In addition, loss of heterozygosity of all the informative loci analyzed was detected in one ovarian teratoma, indicating its post-meiotic origin.
P, Radice, M A, Pierotti, S, Lacerenza, P, Mondini, M T, Radice, S, Pilotti, G, Della Porta   +6 more
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Loss of Heterozygosity in Bilateral Breast Cancer

Breast Cancer Research and Treatment, 2000
Women who develop bilateral breast cancer at an early age are likely to harbour germline mutations in breast cancer susceptibility genes. The aim of this study was to test for concordant genetic changes in left and right breast cancer of young women (age < 50) with bilateral breast cancer that may suggest an inherited breast cancer predisposition ...
J, Kollias, S, Man, M, Marafie, K, Carpenter, S, Pinder, I O, Ellis, R W, Blamey, G, Cross, J D, Brook   +8 more
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Loss of constitutional heterozygosity in human astrocytomas

Acta Neurochirurgica, 1992
Inactivation of tumour suppressor genes or anti-oncogenes as well as activation of dominant acting oncogenes seem to be important mechanisms in the pathogenesis of gliomas. We compared constitutional and tumoural genotypes at different restriction fragment length polymorphism loci (RFLP) on chromosomes 10 and 17 in 15 unrelated individuals.
van de Kelft, Erik, de Boulle, K., Willems, P., Martin, Jean-Jacques, Selosse, Paul, van der Auwera, B.   +5 more
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LOSS OF CONSTITUTIONAL HETEROZYGOSITY IN HUMAN CANCER

Annual Review of Genetics, 1991
INTRODUCTION 282 CANCER AS A GENETIC DISEASE 282 Visible Chromosomal Rearrangements in Tumor Cells. . . . . . . . . . . . . . .. . . . . .. . . . . . . . . . . . . . . 282 Inherited Syndromes Predisposing to Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
D, Lasko, W, Cavenee, M, Nordenskjöld
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Loss of heterozygosity and the origin of meningioma

Human Genetics, 1987
In some human tumors, loss of particular genes manifested indirectly by loss of heterozygosity for specific RFLPs seems to uncover either heterozygous deletions leading to a gene doses effect or homozygous deletions due to a silent allele at the corresponding locus, both causing the loss of regulatory functions (antioncogenes, suppressor genes ...
E, Meese, N, Blin, K D, Zang
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LOSS OF HETEROZYGOSITY - ORIGIN OR RESULT OF CARCINOGENESIS

International Journal of Oncology, 1993
Loss of heterozygosity has recently been discussed in the field of carcinogenesis, since loss of tumor suppressor gene has been believed to play a key role in carcinogenesis. However, recent evidence suggests that the loss of heterozygosity is a non-specific process in tumor progression rather than a specific process of carcinogenesis.
M, Chigira, S, Arita, H, Watanabe
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