Results 61 to 70 of about 138,753 (343)

Analysis of loss of heterozygosity of the tumor suppressor genes p53 and BRCA1 in ovarial carcinomas [PDF]

Vojnosanitetski Pregled, 2006
Background/aim: Among the genes involved in ovarian carcinogenesis, there has been increased interest in tumor-suppressor genes p53 and BRCA1. Both of the genes make control of cell cycle, DNA repair and apoptosis.
Luković Ljiljana, Popović Branka, Atanacković Jasmina, Novaković Ivana, Perović Milica, Petrović Bojana, Petković Spasoje   +6 more
doaj   +1 more source

Supplementary Tables I-IV from FLT3 and JAK2 Mutations in Acute Myeloid Leukemia Promote Interchromosomal Homologous Recombination and the Potential for Copy Neutral Loss of Heterozygosity [PDF]

, 2023
Terry J. Gaymes, Azim Mohamedali, Anthony L. Eiliazadeh, David Darling, Ghulam J. Mufti   +4 more
openalex   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

High-Resolution Detection of Loss of Heterozygosity of Dinucleotide Microsatellite Markers

BioTechniques, 2001
Dinucleotide microsatellite markers are frequently investigated to study inheritance, genetic stability, and allele frequency distribution in a wide variety of genetic disorders. Previous studies have encountered significant problems regarding resolution
Rebecca N. Hourihan, Gerald C. O’Sullivan, John G. Morgan   +2 more
doaj   +1 more source

Venetian local corn (Zea mays L.) germplasm: Disclosing the genetic anatomy of old landraces suited for typical cornmeal mush production. [PDF]

, 2017
Due to growing concern for the genetic erosion of local varieties, four of the main corn landraces historically grown in Veneto (Italy) \u2014 Sponcio, Marano, Biancoperla and Rosso Piave \u2014 were characterized in this work.
Barcaccia, Gianni, Galla, Giulio, Mart\ued\uadnez-Bello, Liliam, Palumbo, Fabio   +3 more
core   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Invasion of Europe by the western corn rootworm, Diabrotica virgifera virgifera: multiple transatlantic introductions with various reductions of genetic diversity [PDF]

, 2008
The early stages of invasion involve demographic bottlenecks that may result in lower genetic variation in introduced populations as compared to source population/s. Low genetic variability may decrease the adaptive potential of such populations in their
Arnaud-Haond, Ayala, Bossdorf, Branson, Cadotte, Cheek, Chen, Cox, Dlugosch, Estoup, Facon, Falconer, Fonseca, Genton, Grevstad, Holland, Johnson, Kang, Kelly, Kim, Kim, Kim, Kiss, Kiss, Kolbe, Krysan, Krysan, Leberg, Levine, Lindholm, Lockwood, McKay, McKinney, Meinke, Merila, Metcalf, Miller, Miller, Nei, Novak, Olden, Ostoja-Starzewski, Paetkau, Parimi, Pascual, Pimentel, Piry, Rannala, Raymond, Raymond, Reed, Reznick, Roman, Roman, Ross, Ruiz, Sax, Schierenbeck, Smith, Sokal, Spencer, Stockwell, Sunnucks, Tsutsui, Van Rozen, Voisin, Wares, Weir, Zayed   +68 more
core   +3 more sources

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Research of loss of heterozygaity on chromosome 3p in non-small cell lung cancer

Chinese Journal of Lung Cancer, 2008
Background and objective It has been proven that allelic loss of chromosome region 3p occurs early and frequently in non-small-cell lung cancer, and numerous tumor suppressor genes at this locus may be targets of inactivation. The aim of this study is to
Xinyu MEI, Yujie SUN, Meiqing XU, Dongchun MA, Dazhong WEI, Jieyong TIAN, Zixue REN   +6 more
doaj