Results 41 to 50 of about 4,964,718 (249)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Evolution of substrate specificity in a retained enzyme driven by gene loss. [PDF]

, 2017
The connection between gene loss and the functional adaptation of retained proteins is still poorly understood. We apply phylogenomics and metabolic modeling to detect bacterial species that are evolving by gene loss, with the finding that ...
Babnigg, Gyorgy, Barona-Gómez, Francisco, Carrillo-Tripp, Mauricio, Edirisinghe, Janaka N, Endres, Michael, Henry, Christopher S, Joachimiak, Andrzej, Juárez-Vázquez, Ana Lilia, Medina-Ruíz, Sofía, Michalska, Karolina, Noda-García, Lianet, Santoyo-Flores, Julián, Ton-That, Hung, Verduzco-Castro, Ernesto A, Wu, Chenggang   +14 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Rate Analysis of Two-Receiver MISO Broadcast Channel with Finite Rate Feedback: A Rate-Splitting Approach

, 2015
To enhance the multiplexing gain of two-receiver Multiple-Input-Single-Output Broadcast Channel with imperfect channel state information at the transmitter (CSIT), a class of Rate-Splitting (RS) approaches has been proposed recently, which divides one ...
Clerckx, Bruno, Hao, Chenxi, Wu, Yueping
core   +1 more source

Low-optical-loss, low-resistance Ag/Ge based ohmic contacts to n-type InP for membrane based waveguide devices [PDF]

, 2015
We present the development of Ag/Ge based ohmic contacts to n-type InP with both low contact resistances and relatively low optical losses. A specific contact resistance as low as 1.5×10-6 O cm2 is achieved by optimizing the Ge layer thickness and ...
Ambrosius, HPMM, Dolores-Calzadilla, V, Heiss, D, Higuera-Rodriguez, A, Jiao, Y, Millan-Mejia, A, Roelkens, Günther, Shen, L, Smit, MK, van der Tol, JJGM, Wullems, CWHA   +10 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Reduced auger recombination in mid-infrared semiconductor lasers [PDF]

, 2011
A quantum-design approach to reduce the Auger losses in two micron InGaSb type-I quantum well edge-emitting lasers is reported. Experimentally realized structures show a 3X reduction in the threshold, which results in 4.6 lower Auger current loss at room
Bedford, Robert, Hader, Jorg, Koch, Stephan W, Moloney, Jerome, Tomich, David H, Triplett, Gregory Edward   +5 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Loss reduction in electromechanically tunable microring cavities

Optics Letters, 2019
Nanophotonic structures coupled with mechanics enable large effective index perturbation. To date, however, the relation between index tuning and induced optical loss has not been considered in detail. In this work we present an in-depth study of optical loss mechanisms in an electromechanically-tunable waveguide filter. Gradient electric forces modify
Marcel W. Pruessner, Doewon Park, Brian J. Roxworthy, Dmitry A. Kozak, Todd H. Stievater, Nathan F. Tyndall, William S. Rabinovich   +6 more
openaire   +2 more sources

Pressure dependence of the dielectric loss in semi-conducting polypyrrole aged at room temperature

, 2010
The effect of physical aging of semi-conducting polypyrrole at ambient temperature for two years duration on the dielectric loss at various pressures is investigated.
A.N. Papathanassiou, Capaccioli, Dutta, Epstein, Fontanella, I. Sakellis, J. Grammatikakis, Kohlman, Mott, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Singh, Singh, Sixou, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Zuppiroli   +29 more
core   +1 more source