Results 61 to 70 of about 5,802,922 (308)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
The Lost Melody Phenomenon [PDF]
, 2015 A typical phenomenon for machine models of transfinite computations is the existence of so-called lost melodies, i.e. real numbers $x$ such that the characteristic function of the set $\{x\}$ is computable while $x$ itself is not (a real having the first
Carl, Merlin
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Years of life that could be saved from prevention of hepatocellular carcinoma [PDF]
, 2016 BACKGROUND: Hepatocellular carcinoma (HCC) causes premature death and loss of life expectancy worldwide. Its primary and secondary prevention can result in a significant number of years of life saved.
Affronti, A. +78 more
core +1 more source
Synthese, 2020 AbstractThis paper develops a puzzle about non-merely-verbal disputes. At first sight, it would seem that a dispute over the truth of an utterance is not merely verbal only if there is a proposition that the parties to the dispute take the utterance under dispute to express, which one of the parties accepts and the other rejects. Yet, as I argue, it is
openaire +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Неврология, нейропсихиатрия, психосоматика, 2010 Physicians have been found to be inadequately aware of the structure of the causes of headache, vertigo, and their clinical importance in patients with essential hypertension. Incorrect ideas lead to the unfounded application of diagnostic techniques for
A. E. Manoylov
doaj +1 more source
Design Deficiencies and Lost Votes [PDF]
, 2011 In 2010, tens of thousands of votes in New York did not count due to overvotes -- the invalid selection of more than one candidate. This report demonstrates how the lack of adequate overvote protections disproportionately affected the state's poorest ...
Lawrence Norden, Sundeep Iyer
core
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source