Results 131 to 140 of about 1,405,729 (293)

Quantitative Visualization of Intracellular Nanometabolism Using Peak‐Shifted Dual‐State Emissive FRET Nanoprobes

Advanced Science, EarlyView.
This study reveals the long‐elusive intracellular dissolution mechanism of carrier‐free nanomedicines. By utilizing peak‐shifted dual‐state emissive FRET nanoprobes (PDFNPs) that undergo a distinct ratiometric fluorescence peak shift upon disassembly, we achieve real‐time, quantitative tracking of dissolution kinetics in live cells.
Farsai Taemaitree, Jinwoo Sung, Yutaro Miki, Ryuju Suzuki, Yoshitaka Koseki, Kunikazu Ishii, Minsang Kim, Keita Tanita, Kota Sato, Toru Nakazawa, Satoshi Katsube, Daisuke Unabara, Tasuku Hamaguchi, Keisuke Kawakami, Koji Yonekura, Akihide Hibara, Atsushi Wakamiya, Hiroshi Uji‐I, Hitoshi Kasai   +18 more
wiley   +1 more source

Prediction and Visualization of Channel Characteristics for Lost Circulation of Drilling Fluid in Fractured Formations

Geofluids
Accurate characterization of the feature parameters of lost circulation channels in fractured formations is of great significance for assessing lost circulation risk and designing effective leakage prevention and plugging strategies.
Jinjun Hu, Sijia Ma, Tie Geng, Wei Zhang, Anguo Xu, Xiaodong Liu, Shuai Zhang   +6 more
doaj   +1 more source

Correction to "Research on a Lost Circulation Zone Location Method Based on Transient Pressure Wave". [PDF]

ACS Omega, 2022
Zhang R, Zhu Z, Wang C, Guan Z.
europepmc   +1 more source

High-Fluid-Loss, High-Strength Lost Circulation Treatments

, 2010
A new high-fluid-loss, high-strength (HFHS) pill system has been developed and optimized using innovative test methods and trialed to ensure that it meets field criteria for addressing lost circulation problems.
Jason T. Scorsone, James E. Friedheim, Mark W. Sanders   +2 more
core   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

Research on the Development and Plugging Capacity of a Honeycomb Porous Lost-Circulation Material. [PDF]

ACS Omega, 2022
Ren J, Xu P, Xu M, Zhang Y, Wang X.
europepmc   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Solution and Analysis of Wellbore Temperature and Pressure Field Coupling Model under Lost Circulation. [PDF]

ACS Omega, 2022
Yang A, Zhu Z, Zhang N, Ye Y.
europepmc   +1 more source

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

Advanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li, Li Sun, Xiaoyu Pan, Shuyi Lin, Dongliang Wang, Jianping Zhang, Fengshuang Qiu, Bin Zhu, Lingzhou Zhao, Fengsheng Zhang, Liyan Bai, Bingxin Gu, Xiaoping Xu, Shaoli Song   +13 more
wiley   +1 more source

Automated lost circulation severity classification and mitigation system using explainable Bayesian optimized ensemble learning algorithms

Journal of Petroleum Exploration and Production Technology
Lost circulation and mud losses cause 10 to 20% of the cost of drilling operations under extreme pressure and temperature conditions. Therefore, this research introduces an integrated system for an automated lost circulation severity classification and ...
Haytham Elmousalami, Ibrahim Sakr
doaj   +1 more source