Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy
Advanced Science, EarlyView.A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu +15 more
wiley +1 more source
Design of a New Lost Circulation Control System
Shiyou jixie, 2017 To address the frequent occurrence of loss circulation during the drilling process and reduce the economic loss, a new type of lost circulation control has been designed.
Yu Yang +3 more
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Experimental Study on Physicochemical Properties of a Shear Thixotropic Polymer Gel for Lost Circulation Control. [PDF]
Gels, 2022 Yang J +5 more
europepmc +1 more source
Advanced Science, EarlyView.A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang +10 more
wiley +1 more source
Research on an Lost Circulation Zone Location Method Based on Transient Pressure Wave. [PDF]
ACS Omega, 2021 Zhang R, Zhu Z, Wang C, Guan Z.
europepmc +1 more source
Aryl‐Tethered Pendant Sterically Shielded Imidazoliums for Durable Anion Exchange Membranes
Advanced Science, EarlyView.An aryl‐tethered, sterically shielded imidazolium architecture protects cationic sites from hydroxide attack while avoiding vulnerable benzylic cation–polymer linkages. Incorporated into poly(arylimidazolium) membranes, this dual‐protection design enhances alkaline and oxidative durability and supports prolonged alkaline water electrolysis, offering a ...
Jinggui Lei +8 more
wiley +1 more source
Novel Expandable Cement System for Prevention of Sustained Casing Pressure and Minimization of Lost Circulation. [PDF]
ACS Omega, 2021 Murtaza M +4 more
europepmc +1 more source
PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling
Advanced Science, EarlyView.PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu +13 more
wiley +1 more source
Advanced Science, EarlyView.After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi +16 more
wiley +1 more source
Research and Application of Intelligent Lost Circulation Diagnosis Model Integrating Logic Rules
Shiyou jixieOffshore oil and gas exploration and development are progressing towards deeper and higher-pressure areas. Complex geological conditions and downhole environments lead to frequent risks of lost circulation.
Wu Liwei +6 more
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