Results 91 to 100 of about 102,342,057 (307)

Long-term outcomes of second-line antiretroviral treatment in an adult and adolescent cohort in Myanmar

Global Health Action, 2017
Background: Myanmar has a high burden of Human Immunodeficiency Virus (HIV) and second-line antiretroviral treatment (ART) has been available since 2008 in the public health sector.
Nang Thu Thu Kyaw, Ajay M. V. Kumar, Myo Minn Oo, Htun Nyunt Oo, Khine Wut Yee Kyaw, Soe Thiha, Thet Ko Aung, Than Win, Yin Yin Mon, Anthony D. Harries   +9 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Tracing patients on antiretroviral treatment lost-to-follow-up in an urban slum in India

, 2012
Aim: This article describes a cooperative initiative between an HIV-clinic and non-government organization network providing lost-to-follow-up tracing and delayed appointment follow-up of patients on antiretroviral treatment. Background: Loss-to-follow-
Claudia Geraets (23402578), P. Isaakidis (23402569), R. Zachariah (3723655), Mohammed Ali (536542), G. Pilankar (23402572), S. Maurya (23402575), L. Errol (23402566)   +6 more
core  

Secondary outcome measures at baseline of followed up and lost to follow-up participants.

, 2019
Secondary outcome measures at baseline of followed up and lost to follow-up participants.
Jonathan Price (3574760), Alison Rushton (773498), M. Sayeed Haque (6686093), Taweewat Wiangkham (773494), Joan Duda (773495)   +4 more
core   +1 more source

Adjusting mortality for loss to follow-up: analysis of five ART programmes in sub-Saharan Africa [PDF]

, 2010
Evaluation of antiretroviral treatment (ART) programmes in sub-Saharan Africa is difficult because many patients are lost to follow-up. Outcomes in these patients are generally unknown but studies tracing patients have shown mortality to be high.
Egger, Matthias, Martin W G Brinkhof, Constantin Yiannoutsos, Ralf Weigel, Brinkhof Martin W. G., Egger Matthias, Sterne, Jonathan A C, Weigel, Ralf, Jonathan A C Sterne, Spycher, Ben D, Robin Wood, Ben D. Spycher, Yiannoutsos, Constantin, Spycher Ben D., Brinkhof, Martin W G, Yiannoutsos Constantin, Martin W. G. Brinkhof, Matthias Egger, Ben D Spycher, Spycher, Ben D., Boulle Andrew, Sterne Jonathan A. C., Sterne, Jonathan A. C., Jonathan A. C. Sterne, Brinkhof, Martin W. G., Weigel Ralf, (IeDEA), for the International epidemiological Database to Evaluate AIDS, Eugène Messou, Wood Robin, International epidemiological Database to Evaluate AIDS (IeDEA), null null, Messou, Eugène, Boulle, Andrew, Andrew Boulle, For The International, Messou Eugène, Wood, Robin, Sterne JA, Yiannoutsos C, Spycher BD, Weigel R, Egger M, Brinkhof MW, Boulle A, Messou E, Wood R   +45 more
core   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Loss to follow-up of patients after antiviral treatment as an additional barrier to HCV elimination

BMC Medicine
Background Eliminating hepatitis C virus (HCV) infections is a goal set by the World Health Organization. This has become possible with the introduction of highly effective and safe direct-acting antivirals (DAA) but limitations remain due to undiagnosed
Dorota Zarębska-Michaluk, Michał Brzdęk, Olga Tronina, Justyna Janocha-Litwin, Marek Sitko, Anna Piekarska, Jakub Klapaczyński, Anna Parfieniuk-Kowerda, Barbara Sobala-Szczygieł, Magdalena Tudrujek-Zdunek, Łukasz Laurans, Robert Flisiak   +11 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Lost to Follow‐Up in Pragmatic Trials With Remote Follow‐Up: Insights From CONNECT‐HF and TRANSFORM‐HF

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Pragmatic trials commonly use remote follow‐up to reduce participant burden and costs. However, these approaches may increase the risk of lost to follow‐up (LTFU).
Satoshi Shoji, Lisa A. Kaltenbach, Haolin Xu, Robert J. Mentz, Bradi B. Granger, Gregg C. Fonarow, Javed Butler, Joseph B. Lerman, Manasi Tannu, Veraprapas Kittipibul, Min Soo Cho, Eric J. Velazquez, Stephen J. Greene, Kevin J. Anstrom, Amanda Harrington, Christopher B. Granger, Adrian F. Hernandez, Adam D. DeVore   +17 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source