Results 111 to 120 of about 102,342,057 (307)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

How lost to follow-up hepatitis C patients achieved and maintained a balancing perspective.

, 2020
How lost to follow-up hepatitis C patients achieved and maintained a balancing perspective.
Andy I. M. Hoepelman (8703615), Sigrid C. J. M. Vervoort (6325742), Patricia A. M. Kracht (8703609), Joop E. Arends (8703612)   +3 more
core   +1 more source

Loss-to-follow-up and delay to treatment initiation in Pakistan’s national tuberculosis control programme

BMC Public Health, 2018
Background Researchers and policy-makers have identified loss to follow-up as a major programmatic problem. Therefore, the objective of this study is to quantify TB related pre-treatment loss to follow up and treatment delay in private sector health care
Syed Mustafa Ali, Farah Naureen, Arif Noor, Irum Fatima, Kerri Viney, Muhammad Ishaq, Naveed Anjum, Aamna Rashid, Ghulam Rasool Haider, Muhammad Aamir Khan, Javariya Aamir   +10 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

PERSEPSI PASIEN HIV/ AIDS MENJADI PENYEBAB LOST TO FOLLOW-UP TERAPI ARV [PDF]

, 2019
Pendahuluan: Penderita HIV / AIDS harus mengonsumsi ARV setiap hari dan rutin kontrol setiap bulannya untuk mengambil ARV di rumah sakit yang membuat penderita beresiko memiliki perilaku lost to follow up.
Purwaningsih, Purwaningsih, Abu, Bakar, Lilik Manowati, -   +2 more
core   +1 more source

Socioeconomic factors as related to the cumulative outcome of mortality and lost to follow-up.

, 2016
Socioeconomic factors as related to the cumulative outcome of mortality and lost to follow-up.
Yajaira Silva Galán (3172050), Marta Medina Manzanarez (3172047), Giuseppina Marra (3172056), Gianni Tognoni (62727), Alberto Edefonti (143842), Fabio Robusto (2136529), Mabel Sandoval Díaz (3172053), Fabio Sereni (3172041), Giovanni Montini (3172044)   +8 more
core   +1 more source

Treatment outcomes of individuals with tuberculosis identified from mobile chest X-ray–based active case finding in Pakistan

Public Health Action
Mobile X-ray–based active case finding is being scaled up across high-burden countries to improve detection of early and asymptomatic tuberculosis (TB). However, limited evidence is available for treatment outcomes in programmatic settings.
S.M.A. Zaidi, K.C. Horton, H. Esmail
doaj   +1 more source

Tracheostomy reversal years after patient lost to follow-up

Journal of Otolaryngology - Head and Neck Surgery, 2018
Background Pediatric tracheostomies occur for various reasons, including prologned intubation, and require a multidisciplinary approach with routine follow-up. Case presentation This report reviews the history and clinical outcome of a 29 year old female
Jill Querney, Jean-Luc Ethier
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source